Mechanism-based screen establishes signalling framework for DNA damage-associated G1 checkpoint response.

Mechanism-based screen establishes signalling framework for DNA damage-associated G1 checkpoint response.

DNA damage activates checkpoint controls which block progression of cells through the division cycle. Several different checkpoints exist that control transit at different positions in the cell cycle. A role for checkpoint activation in providing resistance of cells to genotoxic anticancer therapy,...

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Bibliographic Details
Main Authors:	Elizabeth Richardson, Simon R Stockwell, He Li, Wynne Aherne, Maria Emanuela Cuomo, Sibylle Mittnacht
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2012-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC3288045?pdf=render

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