The Myelin Water Fraction Serves as a Marker for Age-Related Myelin Alterations in the Cerebral White Matter – A Multiparametric MRI Aging Study
Quantitative MRI modalities, such as diffusion tensor imaging (DTI) or magnetization transfer imaging (MTI) are sensitive to the neuronal effects of aging of the cerebral white matter (WM), but lack the specificity for myelin content. Myelin water imaging (MWI) is highly specific for myelin and may...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-02-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fnins.2020.00136/full |
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| author | Tobias D. Faizy Christian Thaler Gabriel Broocks Fabian Flottmann Hannes Leischner Helge Kniep Jawed Nawabi Gerhard Schön Jan-Patrick Stellmann Jan-Patrick Stellmann André Kemmling Ravinder Reddy Jeremy J. Heit Jens Fiehler Dushyant Kumar Dushyant Kumar Uta Hanning |
| author_facet | Tobias D. Faizy Christian Thaler Gabriel Broocks Fabian Flottmann Hannes Leischner Helge Kniep Jawed Nawabi Gerhard Schön Jan-Patrick Stellmann Jan-Patrick Stellmann André Kemmling Ravinder Reddy Jeremy J. Heit Jens Fiehler Dushyant Kumar Dushyant Kumar Uta Hanning |
| author_sort | Tobias D. Faizy |
| collection | DOAJ |
| description | Quantitative MRI modalities, such as diffusion tensor imaging (DTI) or magnetization transfer imaging (MTI) are sensitive to the neuronal effects of aging of the cerebral white matter (WM), but lack the specificity for myelin content. Myelin water imaging (MWI) is highly specific for myelin and may be more sensitive for the detection of changes in myelin content inside the cerebral WM microstructure. In this multiparametric imaging study, we evaluated the performance of myelin water fraction (MWF) estimates as a marker for myelin alterations during normal-aging. Multiparametric MRI data derived from DTI, MTI and a novel, recently-proposed MWF-map processing and reconstruction algorithm were acquired from 54 healthy subjects (aged 18–79 years) and region-based multivariate regression analysis was performed. MWFs significantly decreased with age in most WM regions (except corticospinal tract) and changes of MWFs were associated with changes of radial diffusivity, indicating either substantial alterations or preservation of myelin content in these regions. Decreases of fractional anisotropy and magnetization transfer ratio were associated with lower MWFs in commissural fiber tracts only. Mean diffusivity had no regional effects on MWF. We conclude that MWF estimates are sensitive for the assessment of age-related myelin alterations in the cerebral WM of normal-aging brains. |
| first_indexed | 2024-12-10T07:47:37Z |
| format | Article |
| id | doaj.art-f629a0e06e184876b428da212c28d1ef |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-10T07:47:37Z |
| publishDate | 2020-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-f629a0e06e184876b428da212c28d1ef2022-12-22T01:57:08ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2020-02-011410.3389/fnins.2020.00136514496The Myelin Water Fraction Serves as a Marker for Age-Related Myelin Alterations in the Cerebral White Matter – A Multiparametric MRI Aging StudyTobias D. Faizy0Christian Thaler1Gabriel Broocks2Fabian Flottmann3Hannes Leischner4Helge Kniep5Jawed Nawabi6Gerhard Schön7Jan-Patrick Stellmann8Jan-Patrick Stellmann9André Kemmling10Ravinder Reddy11Jeremy J. Heit12Jens Fiehler13Dushyant Kumar14Dushyant Kumar15Uta Hanning16Department of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, GermanyDepartment of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, GermanyDepartment of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, GermanyDepartment of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, GermanyDepartment of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, GermanyDepartment of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, GermanyDepartment of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, GermanyInstitute of Applied Biometrics and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, GermanyInstitute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf, Hamburg, GermanyDepartment of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, GermanyDepartment of Diagnostic and Interventional Neuroradiology, University Medical Center Muenster, Münster, GermanyDepartment of Radiology, University of Pennsylvania, Philadelphia, PA, United StatesDepartment of Radiology, Stanford University School of Medicine, Palo Alto, CA, United StatesDepartment of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, GermanyDepartment of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, GermanyDepartment of Radiology, University of Pennsylvania, Philadelphia, PA, United StatesDepartment of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, GermanyQuantitative MRI modalities, such as diffusion tensor imaging (DTI) or magnetization transfer imaging (MTI) are sensitive to the neuronal effects of aging of the cerebral white matter (WM), but lack the specificity for myelin content. Myelin water imaging (MWI) is highly specific for myelin and may be more sensitive for the detection of changes in myelin content inside the cerebral WM microstructure. In this multiparametric imaging study, we evaluated the performance of myelin water fraction (MWF) estimates as a marker for myelin alterations during normal-aging. Multiparametric MRI data derived from DTI, MTI and a novel, recently-proposed MWF-map processing and reconstruction algorithm were acquired from 54 healthy subjects (aged 18–79 years) and region-based multivariate regression analysis was performed. MWFs significantly decreased with age in most WM regions (except corticospinal tract) and changes of MWFs were associated with changes of radial diffusivity, indicating either substantial alterations or preservation of myelin content in these regions. Decreases of fractional anisotropy and magnetization transfer ratio were associated with lower MWFs in commissural fiber tracts only. Mean diffusivity had no regional effects on MWF. We conclude that MWF estimates are sensitive for the assessment of age-related myelin alterations in the cerebral WM of normal-aging brains.https://www.frontiersin.org/article/10.3389/fnins.2020.00136/fullT2-relaxometrymyelin water imagingdiffusion imagingmagnetization transfer imagingnormal aging |
| spellingShingle | Tobias D. Faizy Christian Thaler Gabriel Broocks Fabian Flottmann Hannes Leischner Helge Kniep Jawed Nawabi Gerhard Schön Jan-Patrick Stellmann Jan-Patrick Stellmann André Kemmling Ravinder Reddy Jeremy J. Heit Jens Fiehler Dushyant Kumar Dushyant Kumar Uta Hanning The Myelin Water Fraction Serves as a Marker for Age-Related Myelin Alterations in the Cerebral White Matter – A Multiparametric MRI Aging Study Frontiers in Neuroscience T2-relaxometry myelin water imaging diffusion imaging magnetization transfer imaging normal aging |
| title | The Myelin Water Fraction Serves as a Marker for Age-Related Myelin Alterations in the Cerebral White Matter – A Multiparametric MRI Aging Study |
| title_full | The Myelin Water Fraction Serves as a Marker for Age-Related Myelin Alterations in the Cerebral White Matter – A Multiparametric MRI Aging Study |
| title_fullStr | The Myelin Water Fraction Serves as a Marker for Age-Related Myelin Alterations in the Cerebral White Matter – A Multiparametric MRI Aging Study |
| title_full_unstemmed | The Myelin Water Fraction Serves as a Marker for Age-Related Myelin Alterations in the Cerebral White Matter – A Multiparametric MRI Aging Study |
| title_short | The Myelin Water Fraction Serves as a Marker for Age-Related Myelin Alterations in the Cerebral White Matter – A Multiparametric MRI Aging Study |
| title_sort | myelin water fraction serves as a marker for age related myelin alterations in the cerebral white matter a multiparametric mri aging study |
| topic | T2-relaxometry myelin water imaging diffusion imaging magnetization transfer imaging normal aging |
| url | https://www.frontiersin.org/article/10.3389/fnins.2020.00136/full |
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