Neutrophil-to-lymphocyte ratio as a prognostic inflammatory factor in sudden sensorineural hearing loss
Objectives: Sudden sensorineural hearing loss (SSNHL) has recently been investigated in terms of chronic inflammation. In this study, the associations of immunologic inflammatory factors (C-reactive protein [CRP] and erythrocyte sedimentation rate [ESR]) and hematologic inflammatory factors (white b...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2022-12-01
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| Series: | European Journal of Inflammation |
| Online Access: | https://doi.org/10.1177/1721727X221144452 |
| _version_ | 1811208216153948160 |
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| author | Junhui Jeong |
| author_facet | Junhui Jeong |
| author_sort | Junhui Jeong |
| collection | DOAJ |
| description | Objectives: Sudden sensorineural hearing loss (SSNHL) has recently been investigated in terms of chronic inflammation. In this study, the associations of immunologic inflammatory factors (C-reactive protein [CRP] and erythrocyte sedimentation rate [ESR]) and hematologic inflammatory factors (white blood cell [WBC] count, neutrophil percentage, lymphocyte percentage, neutrophil-to-lymphocyte ratio [NLR], and platelet-to-lymphocyte ratio [PLR]) with prognosis of SSNHL were evaluated. Methods: Fifteen patients with SSNHL were prospectively enrolled and followed. For the analysis of the prognostic factors for SSNHL, the patients were divided into two groups according to the final hearing threshold of the affected ear: ‘complete or partial recovery group’ and ‘slight improvement or no recovery group’. The CRP, ESR, WBC count, neutrophil percentage, lymphocyte percentage, NLR, and PLR obtained at the initial visit were compared. Results There were no significant differences in CRP, ESR, WBC count, and PLR between the two groups. In contrast, neutrophil percentage and NLR were significantly lower in the complete or partial recovery group than in the slight improvement or no recovery group ( p = 0.005 and 0.013, respectively). Lymphocyte percentage was significantly higher in the complete or partial recovery group than in the slight improvement or no recovery group ( p = 0.019). Conclusion NLR may be a useful prognostic inflammatory biomarker of SSNHL. Further evaluation of the association of immunologic and hematologic inflammatory factors with the prognosis of SSNHL is necessary with respect to inflammation to reveal additional significant biomarkers because inflammation is related to SSNHL. |
| first_indexed | 2024-04-12T04:18:24Z |
| format | Article |
| id | doaj.art-f62b34e74ffe44029e8e657ef10ceb94 |
| institution | Directory Open Access Journal |
| issn | 2058-7392 |
| language | English |
| last_indexed | 2024-04-12T04:18:24Z |
| publishDate | 2022-12-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | European Journal of Inflammation |
| spelling | doaj.art-f62b34e74ffe44029e8e657ef10ceb942022-12-22T03:48:20ZengSAGE PublishingEuropean Journal of Inflammation2058-73922022-12-012010.1177/1721727X221144452Neutrophil-to-lymphocyte ratio as a prognostic inflammatory factor in sudden sensorineural hearing lossJunhui JeongObjectives: Sudden sensorineural hearing loss (SSNHL) has recently been investigated in terms of chronic inflammation. In this study, the associations of immunologic inflammatory factors (C-reactive protein [CRP] and erythrocyte sedimentation rate [ESR]) and hematologic inflammatory factors (white blood cell [WBC] count, neutrophil percentage, lymphocyte percentage, neutrophil-to-lymphocyte ratio [NLR], and platelet-to-lymphocyte ratio [PLR]) with prognosis of SSNHL were evaluated. Methods: Fifteen patients with SSNHL were prospectively enrolled and followed. For the analysis of the prognostic factors for SSNHL, the patients were divided into two groups according to the final hearing threshold of the affected ear: ‘complete or partial recovery group’ and ‘slight improvement or no recovery group’. The CRP, ESR, WBC count, neutrophil percentage, lymphocyte percentage, NLR, and PLR obtained at the initial visit were compared. Results There were no significant differences in CRP, ESR, WBC count, and PLR between the two groups. In contrast, neutrophil percentage and NLR were significantly lower in the complete or partial recovery group than in the slight improvement or no recovery group ( p = 0.005 and 0.013, respectively). Lymphocyte percentage was significantly higher in the complete or partial recovery group than in the slight improvement or no recovery group ( p = 0.019). Conclusion NLR may be a useful prognostic inflammatory biomarker of SSNHL. Further evaluation of the association of immunologic and hematologic inflammatory factors with the prognosis of SSNHL is necessary with respect to inflammation to reveal additional significant biomarkers because inflammation is related to SSNHL.https://doi.org/10.1177/1721727X221144452 |
| spellingShingle | Junhui Jeong Neutrophil-to-lymphocyte ratio as a prognostic inflammatory factor in sudden sensorineural hearing loss European Journal of Inflammation |
| title | Neutrophil-to-lymphocyte ratio as a prognostic inflammatory factor in sudden sensorineural hearing loss |
| title_full | Neutrophil-to-lymphocyte ratio as a prognostic inflammatory factor in sudden sensorineural hearing loss |
| title_fullStr | Neutrophil-to-lymphocyte ratio as a prognostic inflammatory factor in sudden sensorineural hearing loss |
| title_full_unstemmed | Neutrophil-to-lymphocyte ratio as a prognostic inflammatory factor in sudden sensorineural hearing loss |
| title_short | Neutrophil-to-lymphocyte ratio as a prognostic inflammatory factor in sudden sensorineural hearing loss |
| title_sort | neutrophil to lymphocyte ratio as a prognostic inflammatory factor in sudden sensorineural hearing loss |
| url | https://doi.org/10.1177/1721727X221144452 |
| work_keys_str_mv | AT junhuijeong neutrophiltolymphocyteratioasaprognosticinflammatoryfactorinsuddensensorineuralhearingloss |