mltG gene deletion mitigated virulence potential of Streptococcus mutans: An in-vitro, ex-situ and in-vivo study
Key Points S. mutans is regarded as the most notorious cariogenic pathogen in human oral microbiome. mltG gene acts as terminase and endolytically controls the PG strand elongation in bacteria. Compromised virulence potential of ΔmltG w.r.t. wild type also validated through in-vivo study.
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2023-02-01
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| Series: | AMB Express |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13568-023-01526-x |
| _version_ | 1797863508984987648 |
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| author | Sahar Zaidi Khursheed Ali Yadya M. Chawla Asad U. Khan |
| author_facet | Sahar Zaidi Khursheed Ali Yadya M. Chawla Asad U. Khan |
| author_sort | Sahar Zaidi |
| collection | DOAJ |
| description | Key Points S. mutans is regarded as the most notorious cariogenic pathogen in human oral microbiome. mltG gene acts as terminase and endolytically controls the PG strand elongation in bacteria. Compromised virulence potential of ΔmltG w.r.t. wild type also validated through in-vivo study. |
| first_indexed | 2024-04-09T22:36:37Z |
| format | Article |
| id | doaj.art-f62c1dd4448848f5a3a148cef784c733 |
| institution | Directory Open Access Journal |
| issn | 2191-0855 |
| language | English |
| last_indexed | 2024-04-09T22:36:37Z |
| publishDate | 2023-02-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | AMB Express |
| spelling | doaj.art-f62c1dd4448848f5a3a148cef784c7332023-03-22T12:28:08ZengSpringerOpenAMB Express2191-08552023-02-0113111510.1186/s13568-023-01526-xmltG gene deletion mitigated virulence potential of Streptococcus mutans: An in-vitro, ex-situ and in-vivo studySahar Zaidi0Khursheed Ali1Yadya M. Chawla2Asad U. Khan3Medical Microbiology and Molecular Biology Laboratory, Interdisciplinary, Biotechnology Unit, Aligarh Muslim UniversityMedical Microbiology and Molecular Biology Laboratory, Interdisciplinary, Biotechnology Unit, Aligarh Muslim UniversityICGEB-Emory Vaccine Center, International Centre for Genetic Engineering and BiotechnologyMedical Microbiology and Molecular Biology Laboratory, Interdisciplinary, Biotechnology Unit, Aligarh Muslim UniversityKey Points S. mutans is regarded as the most notorious cariogenic pathogen in human oral microbiome. mltG gene acts as terminase and endolytically controls the PG strand elongation in bacteria. Compromised virulence potential of ΔmltG w.r.t. wild type also validated through in-vivo study.https://doi.org/10.1186/s13568-023-01526-xS. mutansmltGVirulenceBiofilmProteinsDental caries |
| spellingShingle | Sahar Zaidi Khursheed Ali Yadya M. Chawla Asad U. Khan mltG gene deletion mitigated virulence potential of Streptococcus mutans: An in-vitro, ex-situ and in-vivo study AMB Express S. mutans mltG Virulence Biofilm Proteins Dental caries |
| title | mltG gene deletion mitigated virulence potential of Streptococcus mutans: An in-vitro, ex-situ and in-vivo study |
| title_full | mltG gene deletion mitigated virulence potential of Streptococcus mutans: An in-vitro, ex-situ and in-vivo study |
| title_fullStr | mltG gene deletion mitigated virulence potential of Streptococcus mutans: An in-vitro, ex-situ and in-vivo study |
| title_full_unstemmed | mltG gene deletion mitigated virulence potential of Streptococcus mutans: An in-vitro, ex-situ and in-vivo study |
| title_short | mltG gene deletion mitigated virulence potential of Streptococcus mutans: An in-vitro, ex-situ and in-vivo study |
| title_sort | mltg gene deletion mitigated virulence potential of streptococcus mutans an in vitro ex situ and in vivo study |
| topic | S. mutans mltG Virulence Biofilm Proteins Dental caries |
| url | https://doi.org/10.1186/s13568-023-01526-x |
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