Zein Nanoparticles Improve the Oral Bioavailability of Curcumin in Wistar Rats
Curcumin is a natural compound obtained from turmeric root with high antioxidant and anti-inflammatory activities. However, clinical application of curcumin has been limited due to its low solubility and bioavailability and rapid metabolism and degradation. This study was conducted to evaluate the e...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/13/3/361 |
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| author | Ana Brotons-Canto Carlos J. González-Navarro Ana Gloria Gil Eduardo Asin-Prieto María José Saiz Josep Manuel Llabrés |
| author_facet | Ana Brotons-Canto Carlos J. González-Navarro Ana Gloria Gil Eduardo Asin-Prieto María José Saiz Josep Manuel Llabrés |
| author_sort | Ana Brotons-Canto |
| collection | DOAJ |
| description | Curcumin is a natural compound obtained from turmeric root with high antioxidant and anti-inflammatory activities. However, clinical application of curcumin has been limited due to its low solubility and bioavailability and rapid metabolism and degradation. This study was conducted to evaluate the effect of curcumin incorporation in zein nanoparticles on the pharmacokinetic parameters of systemic curcumin in plasma. Wistar rats were administered a single oral dose of 250 mg/kg of standard curcumin (control) or nanocurcumin (zein-based nanoparticles, Nucaps). The proposed new formulation was also compared with two commercially available curcumin complexes. Blood samples were collected at different times, and plasma levels were determined using HPLC-MS/MS. Overall, nanocurcumin (Nucaps) formulation was well tolerated and showed a 9-fold increase in oral bioavailability when compared to the standard curcumin natural extract. In addition, the nanoparticles prepared in this study demonstrated a bioavailability profile superior to that of other bioavailability-enhanced curcumin complexes currently available in the marketplace. Thus, our nanoparticle-based formulation has shown great potential as a nutraceutical for the oral administration of curcumin. |
| first_indexed | 2024-03-10T13:25:41Z |
| format | Article |
| id | doaj.art-f62c509bdfda409a833b3fdb090b2807 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T13:25:41Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-f62c509bdfda409a833b3fdb090b28072023-11-21T09:44:09ZengMDPI AGPharmaceutics1999-49232021-03-0113336110.3390/pharmaceutics13030361Zein Nanoparticles Improve the Oral Bioavailability of Curcumin in Wistar RatsAna Brotons-Canto0Carlos J. González-Navarro1Ana Gloria Gil2Eduardo Asin-Prieto3María José Saiz4Josep Manuel Llabrés5Nucaps Nanotechnology S.L., 31110 Noain, SpainCenter for Nutrition Research, University of Navarra, 31008 Pamplona, SpainDrug Development Unit, Department of Pharmacology and Toxicology, Faculty of Pharmacy and Nutrition, University of Navarra, 31008 Pamplona, SpainInserm U1070, Pôle Biologie Santé, Université de Poitiers, 86000 Poitiers, FranceNational Center for Food Technology and Safety, CNTA, 31570 San Adrian, SpainPlantas Medicinales y Complementos Alimenticios, S.A. (PLAMECA), 08780 Palleja, SpainCurcumin is a natural compound obtained from turmeric root with high antioxidant and anti-inflammatory activities. However, clinical application of curcumin has been limited due to its low solubility and bioavailability and rapid metabolism and degradation. This study was conducted to evaluate the effect of curcumin incorporation in zein nanoparticles on the pharmacokinetic parameters of systemic curcumin in plasma. Wistar rats were administered a single oral dose of 250 mg/kg of standard curcumin (control) or nanocurcumin (zein-based nanoparticles, Nucaps). The proposed new formulation was also compared with two commercially available curcumin complexes. Blood samples were collected at different times, and plasma levels were determined using HPLC-MS/MS. Overall, nanocurcumin (Nucaps) formulation was well tolerated and showed a 9-fold increase in oral bioavailability when compared to the standard curcumin natural extract. In addition, the nanoparticles prepared in this study demonstrated a bioavailability profile superior to that of other bioavailability-enhanced curcumin complexes currently available in the marketplace. Thus, our nanoparticle-based formulation has shown great potential as a nutraceutical for the oral administration of curcumin.https://www.mdpi.com/1999-4923/13/3/361antioxidantbioavailabilitycurcumincurcuminoidnanoparticles |
| spellingShingle | Ana Brotons-Canto Carlos J. González-Navarro Ana Gloria Gil Eduardo Asin-Prieto María José Saiz Josep Manuel Llabrés Zein Nanoparticles Improve the Oral Bioavailability of Curcumin in Wistar Rats Pharmaceutics antioxidant bioavailability curcumin curcuminoid nanoparticles |
| title | Zein Nanoparticles Improve the Oral Bioavailability of Curcumin in Wistar Rats |
| title_full | Zein Nanoparticles Improve the Oral Bioavailability of Curcumin in Wistar Rats |
| title_fullStr | Zein Nanoparticles Improve the Oral Bioavailability of Curcumin in Wistar Rats |
| title_full_unstemmed | Zein Nanoparticles Improve the Oral Bioavailability of Curcumin in Wistar Rats |
| title_short | Zein Nanoparticles Improve the Oral Bioavailability of Curcumin in Wistar Rats |
| title_sort | zein nanoparticles improve the oral bioavailability of curcumin in wistar rats |
| topic | antioxidant bioavailability curcumin curcuminoid nanoparticles |
| url | https://www.mdpi.com/1999-4923/13/3/361 |
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