A Review of Genetic Polymorphisms and Susceptibilities to Complications after Aneurysmal Subarachnoid Hemorrhage
Delayed cerebral ischemia (DCI) and vasospasm are two complications of subarachnoid hemorrhages (SAHs) which entail high risks of morbidity and mortality. However, it is unknown why only some patients who suffer SAHs will experience DCI and vasospasm. The purpose of this review is to describe the ma...
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MDPI AG
2022-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/23/15427 |
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| author | Jose Medina-Suárez Francisco Rodríguez-Esparragón Coralia Sosa-Pérez Sara Cazorla-Rivero Laura B. Torres-Mata Aruma Jiménez-O’Shanahan Bernardino Clavo Jesús Morera-Molina |
| author_facet | Jose Medina-Suárez Francisco Rodríguez-Esparragón Coralia Sosa-Pérez Sara Cazorla-Rivero Laura B. Torres-Mata Aruma Jiménez-O’Shanahan Bernardino Clavo Jesús Morera-Molina |
| author_sort | Jose Medina-Suárez |
| collection | DOAJ |
| description | Delayed cerebral ischemia (DCI) and vasospasm are two complications of subarachnoid hemorrhages (SAHs) which entail high risks of morbidity and mortality. However, it is unknown why only some patients who suffer SAHs will experience DCI and vasospasm. The purpose of this review is to describe the main genetic single nucleotide polymorphisms (SNPs) that have demonstrated a relationship with these complications. The SNP of the nitric oxide endothelial synthase (eNOS) has been related to the size and rupture of an aneurysm, as well as to DCI, vasospasm, and poor neurological outcome. The SNPs responsible for the asymmetric dimetilarginine and the high-mobility group box 1 have also been associated with DCI. An association between vasospasm and the SNPs of the eNOS, the haptoglobin, and the endothelin-1 receptor has been found. The SNPs of the angiotensin-converting enzyme have been related to DCI and poor neurological outcome. Studies on the SNPs of the Ryanodine Receptor yielded varying results regarding their association with vasospasm. |
| first_indexed | 2024-03-09T17:45:04Z |
| format | Article |
| id | doaj.art-f62d730bfa5748ea8d8fade7fee2b9ce |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T17:45:04Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-f62d730bfa5748ea8d8fade7fee2b9ce2023-11-24T11:18:52ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-12-0123231542710.3390/ijms232315427A Review of Genetic Polymorphisms and Susceptibilities to Complications after Aneurysmal Subarachnoid HemorrhageJose Medina-Suárez0Francisco Rodríguez-Esparragón1Coralia Sosa-Pérez2Sara Cazorla-Rivero3Laura B. Torres-Mata4Aruma Jiménez-O’Shanahan5Bernardino Clavo6Jesús Morera-Molina7Research Unit, University Hospital of Gran Canaria Dr. Negrín, 35010 Gran Canaria, SpainResearch Unit, University Hospital of Gran Canaria Dr. Negrín, 35010 Gran Canaria, SpainNeurosurgery Unit, University Hospital of Gran Canaria Dr. Negrín, 35010 Gran Canaria, SpainResearch Unit, University Hospital of Gran Canaria Dr. Negrín, 35010 Gran Canaria, SpainResearch Unit, University Hospital of Gran Canaria Dr. Negrín, 35010 Gran Canaria, SpainNeurosurgery Unit, University Hospital of Gran Canaria Dr. Negrín, 35010 Gran Canaria, SpainResearch Unit, University Hospital of Gran Canaria Dr. Negrín, 35010 Gran Canaria, SpainNeurosurgery Unit, University Hospital of Gran Canaria Dr. Negrín, 35010 Gran Canaria, SpainDelayed cerebral ischemia (DCI) and vasospasm are two complications of subarachnoid hemorrhages (SAHs) which entail high risks of morbidity and mortality. However, it is unknown why only some patients who suffer SAHs will experience DCI and vasospasm. The purpose of this review is to describe the main genetic single nucleotide polymorphisms (SNPs) that have demonstrated a relationship with these complications. The SNP of the nitric oxide endothelial synthase (eNOS) has been related to the size and rupture of an aneurysm, as well as to DCI, vasospasm, and poor neurological outcome. The SNPs responsible for the asymmetric dimetilarginine and the high-mobility group box 1 have also been associated with DCI. An association between vasospasm and the SNPs of the eNOS, the haptoglobin, and the endothelin-1 receptor has been found. The SNPs of the angiotensin-converting enzyme have been related to DCI and poor neurological outcome. Studies on the SNPs of the Ryanodine Receptor yielded varying results regarding their association with vasospasm.https://www.mdpi.com/1422-0067/23/23/15427polymorphismaneurysmal subarachnoid hemorrhagevasospasmdelayed cerebral ischemianeurological outcome |
| spellingShingle | Jose Medina-Suárez Francisco Rodríguez-Esparragón Coralia Sosa-Pérez Sara Cazorla-Rivero Laura B. Torres-Mata Aruma Jiménez-O’Shanahan Bernardino Clavo Jesús Morera-Molina A Review of Genetic Polymorphisms and Susceptibilities to Complications after Aneurysmal Subarachnoid Hemorrhage International Journal of Molecular Sciences polymorphism aneurysmal subarachnoid hemorrhage vasospasm delayed cerebral ischemia neurological outcome |
| title | A Review of Genetic Polymorphisms and Susceptibilities to Complications after Aneurysmal Subarachnoid Hemorrhage |
| title_full | A Review of Genetic Polymorphisms and Susceptibilities to Complications after Aneurysmal Subarachnoid Hemorrhage |
| title_fullStr | A Review of Genetic Polymorphisms and Susceptibilities to Complications after Aneurysmal Subarachnoid Hemorrhage |
| title_full_unstemmed | A Review of Genetic Polymorphisms and Susceptibilities to Complications after Aneurysmal Subarachnoid Hemorrhage |
| title_short | A Review of Genetic Polymorphisms and Susceptibilities to Complications after Aneurysmal Subarachnoid Hemorrhage |
| title_sort | review of genetic polymorphisms and susceptibilities to complications after aneurysmal subarachnoid hemorrhage |
| topic | polymorphism aneurysmal subarachnoid hemorrhage vasospasm delayed cerebral ischemia neurological outcome |
| url | https://www.mdpi.com/1422-0067/23/23/15427 |
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