Relationship of choroidal thickness with pulsatile hemodynamics in essential hypertensive patients
Abstract Controversy exists about the association of choroidal thickness (CTh) with blood pressure (BP) values. There is some evidence suggesting that central hemodynamics changes are associated with microvascular disease. Our study was aimed to assess the relationships between CTh and clinic and 24...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-05-01
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| Series: | The Journal of Clinical Hypertension |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jch.14196 |
| _version_ | 1797645201094737920 |
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| author | Giuseppe Mulè Maria Vadalà Nicola Sinatra Ettore Mancia Alessandra Sorce Giulio Geraci Caterina Carollo Katia Montalbano Massimo Castellucci Giulia Guarrasi Salvatore Cillino Santina Cottone |
| author_facet | Giuseppe Mulè Maria Vadalà Nicola Sinatra Ettore Mancia Alessandra Sorce Giulio Geraci Caterina Carollo Katia Montalbano Massimo Castellucci Giulia Guarrasi Salvatore Cillino Santina Cottone |
| author_sort | Giuseppe Mulè |
| collection | DOAJ |
| description | Abstract Controversy exists about the association of choroidal thickness (CTh) with blood pressure (BP) values. There is some evidence suggesting that central hemodynamics changes are associated with microvascular disease. Our study was aimed to assess the relationships between CTh and clinic and 24‐h BP and between CTh and estimated 24‐h aortic pulse pressure (aPP), 24‐h aortic systolic BP (aSBP), and 24‐h aortic augmentation index (aAIx) in a group of hypertensive patients. We enrolled 158 hypertensive subjects (mean age 48 ± 13 years) all of which underwent evaluation of the choroidal district by Swept‐Source optical coherence tomography (SS‐OCT) and 24‐h BP monitoring, in order to measure peripheral BP and to estimate central hemodynamic parameters. Inverse significant correlations of clinic PP, 24‐h aPP, 24‐h aSBP, and 24‐h aAIx with thicknesses of central ring, inner ring, and outer ring of the choroid and its overall average were found. The strongest of these correlations was that relating 24‐h aPP with overall average choroidal thickness (r = −.531; P < .001). When we divided the study population in subjects with 24‐h aPP above and below the median value (35 mm Hg), CTh were thinner in subjects with higher values of 24‐aPP as compared to those with lower ones, even after adjustment for age, and other potential confounders. The relationships of CTh with 24‐h aPP remained significant also taking into account the effects of various covariates in linear multiple regression analyses. Our findings support the concept of a cross‐talk between macro‐ and microcirculation. |
| first_indexed | 2024-03-11T14:42:55Z |
| format | Article |
| id | doaj.art-f62d7e13c7614589afbf1a4294fa8ff6 |
| institution | Directory Open Access Journal |
| issn | 1524-6175 1751-7176 |
| language | English |
| last_indexed | 2024-03-11T14:42:55Z |
| publishDate | 2021-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Journal of Clinical Hypertension |
| spelling | doaj.art-f62d7e13c7614589afbf1a4294fa8ff62023-10-30T13:30:30ZengWileyThe Journal of Clinical Hypertension1524-61751751-71762021-05-012351030103810.1111/jch.14196Relationship of choroidal thickness with pulsatile hemodynamics in essential hypertensive patientsGiuseppe Mulè0Maria Vadalà1Nicola Sinatra2Ettore Mancia3Alessandra Sorce4Giulio Geraci5Caterina Carollo6Katia Montalbano7Massimo Castellucci8Giulia Guarrasi9Salvatore Cillino10Santina Cottone11Department of Health Promotion Sciences, Maternal and Infant Care Internal Medicine and Medical Specialties “G. D’Alessandro” (PROMISE) University of Palermo Palermo ItalyDipartimento di Biomedicina sperimentale e Neuroscienze cliniche Università degli studi di Palermo Palermo ItalyDepartment of Health Promotion Sciences, Maternal and Infant Care Internal Medicine and Medical Specialties “G. D’Alessandro” (PROMISE) University of Palermo Palermo ItalyDepartment of Health Promotion Sciences, Maternal and Infant Care Internal Medicine and Medical Specialties “G. D’Alessandro” (PROMISE) University of Palermo Palermo ItalyDepartment of Health Promotion Sciences, Maternal and Infant Care Internal Medicine and Medical Specialties “G. D’Alessandro” (PROMISE) University of Palermo Palermo ItalyDepartment of Health Promotion Sciences, Maternal and Infant Care Internal Medicine and Medical Specialties “G. D’Alessandro” (PROMISE) University of Palermo Palermo ItalyDepartment of Health Promotion Sciences, Maternal and Infant Care Internal Medicine and Medical Specialties “G. D’Alessandro” (PROMISE) University of Palermo Palermo ItalyDepartment of Health Promotion Sciences, Maternal and Infant Care Internal Medicine and Medical Specialties “G. D’Alessandro” (PROMISE) University of Palermo Palermo ItalyDipartimento di Biomedicina sperimentale e Neuroscienze cliniche Università degli studi di Palermo Palermo ItalyDipartimento di Biomedicina sperimentale e Neuroscienze cliniche Università degli studi di Palermo Palermo ItalyDipartimento di Biomedicina sperimentale e Neuroscienze cliniche Università degli studi di Palermo Palermo ItalyDepartment of Health Promotion Sciences, Maternal and Infant Care Internal Medicine and Medical Specialties “G. D’Alessandro” (PROMISE) University of Palermo Palermo ItalyAbstract Controversy exists about the association of choroidal thickness (CTh) with blood pressure (BP) values. There is some evidence suggesting that central hemodynamics changes are associated with microvascular disease. Our study was aimed to assess the relationships between CTh and clinic and 24‐h BP and between CTh and estimated 24‐h aortic pulse pressure (aPP), 24‐h aortic systolic BP (aSBP), and 24‐h aortic augmentation index (aAIx) in a group of hypertensive patients. We enrolled 158 hypertensive subjects (mean age 48 ± 13 years) all of which underwent evaluation of the choroidal district by Swept‐Source optical coherence tomography (SS‐OCT) and 24‐h BP monitoring, in order to measure peripheral BP and to estimate central hemodynamic parameters. Inverse significant correlations of clinic PP, 24‐h aPP, 24‐h aSBP, and 24‐h aAIx with thicknesses of central ring, inner ring, and outer ring of the choroid and its overall average were found. The strongest of these correlations was that relating 24‐h aPP with overall average choroidal thickness (r = −.531; P < .001). When we divided the study population in subjects with 24‐h aPP above and below the median value (35 mm Hg), CTh were thinner in subjects with higher values of 24‐aPP as compared to those with lower ones, even after adjustment for age, and other potential confounders. The relationships of CTh with 24‐h aPP remained significant also taking into account the effects of various covariates in linear multiple regression analyses. Our findings support the concept of a cross‐talk between macro‐ and microcirculation.https://doi.org/10.1111/jch.14196aortic pressurecardiovascular diseasecentral hemodynamicschoroidal thicknesshypertensive eye diseasemicrocirculation |
| spellingShingle | Giuseppe Mulè Maria Vadalà Nicola Sinatra Ettore Mancia Alessandra Sorce Giulio Geraci Caterina Carollo Katia Montalbano Massimo Castellucci Giulia Guarrasi Salvatore Cillino Santina Cottone Relationship of choroidal thickness with pulsatile hemodynamics in essential hypertensive patients The Journal of Clinical Hypertension aortic pressure cardiovascular disease central hemodynamics choroidal thickness hypertensive eye disease microcirculation |
| title | Relationship of choroidal thickness with pulsatile hemodynamics in essential hypertensive patients |
| title_full | Relationship of choroidal thickness with pulsatile hemodynamics in essential hypertensive patients |
| title_fullStr | Relationship of choroidal thickness with pulsatile hemodynamics in essential hypertensive patients |
| title_full_unstemmed | Relationship of choroidal thickness with pulsatile hemodynamics in essential hypertensive patients |
| title_short | Relationship of choroidal thickness with pulsatile hemodynamics in essential hypertensive patients |
| title_sort | relationship of choroidal thickness with pulsatile hemodynamics in essential hypertensive patients |
| topic | aortic pressure cardiovascular disease central hemodynamics choroidal thickness hypertensive eye disease microcirculation |
| url | https://doi.org/10.1111/jch.14196 |
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