The ER Stress Inducer <span style="font-variant: small-caps">l</span>-Azetidine-2-Carboxylic Acid Elevates the Levels of Phospho-eIF2α and of LC3-II in a Ca<sup>2+</sup>-Dependent Manner

The ER Stress Inducer <span style="font-variant: small-caps">l</span>-Azetidine-2-Carboxylic Acid Elevates the Levels of Phospho-eIF2α and of LC3-II in a Ca<sup>2+</sup>-Dependent Manner

Accumulation of misfolded proteins in the endoplasmic reticulum (ER) activates the unfolded protein response (UPR) to reduce protein load and restore homeostasis, including via induction of autophagy. We used the proline analogue <span style="font-variant: small-caps;">l</span>...

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Bibliographic Details
Main Authors: Gemma Roest, Evelien Hesemans, Kirsten Welkenhuyzen, Tomas Luyten, Nikolai Engedal, Geert Bultynck, Jan B. Parys
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:Cells
Subjects:
autophagy
ER stress
UPR
PERK
Ca<sup>2+</sup>
<span style="font-variant: small-caps">l</span>-azetidine-2-carboxylic acid
Online Access:https://www.mdpi.com/2073-4409/7/12/239

Internet

https://www.mdpi.com/2073-4409/7/12/239

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