Plasmacytoid dendritic cells: neglected regulators of the immune response to Staphylococcus aureus
Plasmacytoid dendritic cells (pDC) are a rare subset of leukocytes equipped with Fcgamma and Fcepsilon receptors, which exert contrary effects on sensing of microbial nucleic acids by endosomal Toll-like receptors. In this article we explain how pDC contribute to the immune response to Staphylococcu...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-05-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00238/full |
| _version_ | 1818241494953230336 |
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| author | Isabelle eBekeredjian-Ding Johann eGreil Sandra eAmmann Marijo eParcina |
| author_facet | Isabelle eBekeredjian-Ding Johann eGreil Sandra eAmmann Marijo eParcina |
| author_sort | Isabelle eBekeredjian-Ding |
| collection | DOAJ |
| description | Plasmacytoid dendritic cells (pDC) are a rare subset of leukocytes equipped with Fcgamma and Fcepsilon receptors, which exert contrary effects on sensing of microbial nucleic acids by endosomal Toll-like receptors. In this article we explain how pDC contribute to the immune response to Staphylococcus aureus. Under normal circumstances the pDC participates in the memory response to the pathogen: pDC activation is initiated by uptake of staphylococcal immune complexes with IgG or IgE. However, protein A-expressing S. aureus strains additionally trigger pDC activation in the absence of immunoglobulin. In this context staphylococci exploit the pDC to induce antigen-independent differentiation of IL-10 producing plasmablasts, an elegant means to propagate immune evasion. We further discuss the role of type I interferons in infection with S. aureus and the implications of these findings for the development of immune based therapies and vaccination. |
| first_indexed | 2024-12-12T13:30:14Z |
| format | Article |
| id | doaj.art-f62fd61c27b945ba9f0f8b3f8f7e4654 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-12T13:30:14Z |
| publishDate | 2014-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-f62fd61c27b945ba9f0f8b3f8f7e46542022-12-22T00:23:05ZengFrontiers Media S.A.Frontiers in Immunology1664-32242014-05-01510.3389/fimmu.2014.0023883557Plasmacytoid dendritic cells: neglected regulators of the immune response to Staphylococcus aureusIsabelle eBekeredjian-Ding0Johann eGreil1Sandra eAmmann2Marijo eParcina3University Hospital BonnUniversity Hospital HeidelbergUniversity Hospital HeidelbergUniversity Hospital BonnPlasmacytoid dendritic cells (pDC) are a rare subset of leukocytes equipped with Fcgamma and Fcepsilon receptors, which exert contrary effects on sensing of microbial nucleic acids by endosomal Toll-like receptors. In this article we explain how pDC contribute to the immune response to Staphylococcus aureus. Under normal circumstances the pDC participates in the memory response to the pathogen: pDC activation is initiated by uptake of staphylococcal immune complexes with IgG or IgE. However, protein A-expressing S. aureus strains additionally trigger pDC activation in the absence of immunoglobulin. In this context staphylococci exploit the pDC to induce antigen-independent differentiation of IL-10 producing plasmablasts, an elegant means to propagate immune evasion. We further discuss the role of type I interferons in infection with S. aureus and the implications of these findings for the development of immune based therapies and vaccination.http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00238/fullAutoimmunityBacteriaStaphylococcus aureustoleranceimmune complexesallergy |
| spellingShingle | Isabelle eBekeredjian-Ding Johann eGreil Sandra eAmmann Marijo eParcina Plasmacytoid dendritic cells: neglected regulators of the immune response to Staphylococcus aureus Frontiers in Immunology Autoimmunity Bacteria Staphylococcus aureus tolerance immune complexes allergy |
| title | Plasmacytoid dendritic cells: neglected regulators of the immune response to Staphylococcus aureus |
| title_full | Plasmacytoid dendritic cells: neglected regulators of the immune response to Staphylococcus aureus |
| title_fullStr | Plasmacytoid dendritic cells: neglected regulators of the immune response to Staphylococcus aureus |
| title_full_unstemmed | Plasmacytoid dendritic cells: neglected regulators of the immune response to Staphylococcus aureus |
| title_short | Plasmacytoid dendritic cells: neglected regulators of the immune response to Staphylococcus aureus |
| title_sort | plasmacytoid dendritic cells neglected regulators of the immune response to staphylococcus aureus |
| topic | Autoimmunity Bacteria Staphylococcus aureus tolerance immune complexes allergy |
| url | http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00238/full |
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