Association of TNF-α, IFN-γ, IL-6, and IL-10 with different clinical manifestations of hepatitis B infection
Cytokines have a crucial part in the pathogenesis, persistence of infection, and prognosis of hepatitis B virus (HBV) infection as HBV does not cause direct liver destruction; rather, disease-related complications and prognosis are more associated with immune system action, specifically cytokines s...
| Những tác giả chính: | , , , , , , , |
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| Định dạng: | Bài viết |
| Ngôn ngữ: | English |
| Được phát hành: |
PAGEPress Publications
2023-07-01
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| Loạt: | Italian Journal of Medicine |
| Những chủ đề: | |
| Truy cập trực tuyến: | https://www.italjmed.org/index.php/ijm/article/view/1627 |
| _version_ | 1827605781982216192 |
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| author | Mudathir Abdelshafea Abdelkareem Abakar Ashwag Ali Hussein Ali Eman Damra Ahmed Elhassan Esra Ali Hamuda Altaher Nosaiba Hussein Abdalbasit Musa Shamsoun Khamis Kafi Amira Eltom Fawzi Osman Hisham Ali Waggiallah |
| author_facet | Mudathir Abdelshafea Abdelkareem Abakar Ashwag Ali Hussein Ali Eman Damra Ahmed Elhassan Esra Ali Hamuda Altaher Nosaiba Hussein Abdalbasit Musa Shamsoun Khamis Kafi Amira Eltom Fawzi Osman Hisham Ali Waggiallah |
| author_sort | Mudathir Abdelshafea Abdelkareem Abakar |
| collection | DOAJ |
| description |
Cytokines have a crucial part in the pathogenesis, persistence of infection, and prognosis of hepatitis B virus (HBV) infection as HBV does not cause direct liver destruction; rather, disease-related complications and prognosis are more associated with immune system action, specifically cytokines such as TNF-α, IFN-γ, IL-6, IL-10, and other cytokines. This study sought to link TNF-, IFN-, IL-6, and IL-10 to various clinical manifestations of HBV infection. Ninety sera were taken from HBV-infected patients, 30 (33.3%) of whom had liver cirrhosis, 30 (33.3%) were HBV carriers, 19 (21.2%) were acute HBV patients, and 11 (12.2%) were recently HBV infected. ELISA was used to determine the serum levels of TNF-α, IFN-γ, IL-6, and IL-10. HBV-infected patients with liver cirrhosis had considerably higher mean serum levels of IFN-γ (P=0.005) and IL-10 (P=0.003), but TNF-α and IL-6 were significantly higher in recent HBV-infected patients (P values 0.034 and 0.004, respectively). There were substantial changes in mean serum levels of TNF-α, IFN-γ, IL-6, and IL-10 at different phases of HBV infection, implying a role for cytokines in HBV etiology, chronicity, and consequences.
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| first_indexed | 2024-03-09T06:26:26Z |
| format | Article |
| id | doaj.art-f6359143112a4b3f8c3271c185765790 |
| institution | Directory Open Access Journal |
| issn | 1877-9344 1877-9352 |
| language | English |
| last_indexed | 2024-03-09T06:26:26Z |
| publishDate | 2023-07-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Italian Journal of Medicine |
| spelling | doaj.art-f6359143112a4b3f8c3271c1857657902023-12-03T11:20:55ZengPAGEPress PublicationsItalian Journal of Medicine1877-93441877-93522023-07-0117110.4081/itjm.2023.1627Association of TNF-α, IFN-γ, IL-6, and IL-10 with different clinical manifestations of hepatitis B infectionMudathir Abdelshafea Abdelkareem Abakar0Ashwag Ali Hussein Ali1Eman Damra Ahmed Elhassan2Esra Ali Hamuda Altaher3Nosaiba Hussein Abdalbasit Musa4Shamsoun Khamis Kafi5Amira Eltom Fawzi Osman6Hisham Ali Waggiallah7Department of Microbiology and Immunology, Faculty of Medical Laboratory Sciences, Alzaiem Alazhari University, Khartoum North, KhartoumDepartment of Microbiology and Immunology, Faculty of Medical Laboratory Sciences, Alzaiem Alazhari University, Khartoum North, KhartoumDepartment of Microbiology and Immunology, Faculty of Medical Laboratory Sciences, Alzaiem Alazhari University, Khartoum North, KhartoumDepartment of Microbiology and Immunology, Faculty of Medical Laboratory Sciences, Alzaiem Alazhari University, Khartoum North, KhartoumDepartment of Microbiology and Immunology, Faculty of Medical Laboratory Sciences, Alzaiem Alazhari University, Khartoum North, KhartoumDepartment of Microbiology, Faculty of Medical Laboratory Sciences-National Ribat University, KhartoumDepartment of Microbiology and Immunology, Faculty of Medical Laboratory Sciences, Alzaiem Alazhari University, Khartoum North, KhartoumDepartment of Medical Laboratory Science, College of Applied Medical Science, Prince Sattam Bin Abdulaziz University, Alkharj Cytokines have a crucial part in the pathogenesis, persistence of infection, and prognosis of hepatitis B virus (HBV) infection as HBV does not cause direct liver destruction; rather, disease-related complications and prognosis are more associated with immune system action, specifically cytokines such as TNF-α, IFN-γ, IL-6, IL-10, and other cytokines. This study sought to link TNF-, IFN-, IL-6, and IL-10 to various clinical manifestations of HBV infection. Ninety sera were taken from HBV-infected patients, 30 (33.3%) of whom had liver cirrhosis, 30 (33.3%) were HBV carriers, 19 (21.2%) were acute HBV patients, and 11 (12.2%) were recently HBV infected. ELISA was used to determine the serum levels of TNF-α, IFN-γ, IL-6, and IL-10. HBV-infected patients with liver cirrhosis had considerably higher mean serum levels of IFN-γ (P=0.005) and IL-10 (P=0.003), but TNF-α and IL-6 were significantly higher in recent HBV-infected patients (P values 0.034 and 0.004, respectively). There were substantial changes in mean serum levels of TNF-α, IFN-γ, IL-6, and IL-10 at different phases of HBV infection, implying a role for cytokines in HBV etiology, chronicity, and consequences. https://www.italjmed.org/index.php/ijm/article/view/1627TNF-αIFN-γIL-6IL-10HBV |
| spellingShingle | Mudathir Abdelshafea Abdelkareem Abakar Ashwag Ali Hussein Ali Eman Damra Ahmed Elhassan Esra Ali Hamuda Altaher Nosaiba Hussein Abdalbasit Musa Shamsoun Khamis Kafi Amira Eltom Fawzi Osman Hisham Ali Waggiallah Association of TNF-α, IFN-γ, IL-6, and IL-10 with different clinical manifestations of hepatitis B infection Italian Journal of Medicine TNF-α IFN-γ IL-6 IL-10 HBV |
| title | Association of TNF-α, IFN-γ, IL-6, and IL-10 with different clinical manifestations of hepatitis B infection |
| title_full | Association of TNF-α, IFN-γ, IL-6, and IL-10 with different clinical manifestations of hepatitis B infection |
| title_fullStr | Association of TNF-α, IFN-γ, IL-6, and IL-10 with different clinical manifestations of hepatitis B infection |
| title_full_unstemmed | Association of TNF-α, IFN-γ, IL-6, and IL-10 with different clinical manifestations of hepatitis B infection |
| title_short | Association of TNF-α, IFN-γ, IL-6, and IL-10 with different clinical manifestations of hepatitis B infection |
| title_sort | association of tnf α ifn γ il 6 and il 10 with different clinical manifestations of hepatitis b infection |
| topic | TNF-α IFN-γ IL-6 IL-10 HBV |
| url | https://www.italjmed.org/index.php/ijm/article/view/1627 |
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