The early-life exposome and epigenetic age acceleration in children
The early-life exposome influences future health and accelerated biological aging has been proposed as one of the underlying biological mechanisms. We investigated the association between more than 100 exposures assessed during pregnancy and in childhood (including indoor and outdoor air pollutants,...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-10-01
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| Series: | Environment International |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412021003081 |
| _version_ | 1818922349665189888 |
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| author | Paula de Prado-Bert Carlos Ruiz-Arenas Marta Vives-Usano Sandra Andrusaityte Solène Cadiou Ángel Carracedo Maribel Casas Leda Chatzi Payam Dadvand Juan R. González Regina Grazuleviciene Kristine B. Gutzkow Line S. Haug Carles Hernandez-Ferrer Hector C. Keun Johanna Lepeule Léa Maitre Rosie McEachan Mark J. Nieuwenhuijsen Dolors Pelegrí Oliver Robinson Rémy Slama Marina Vafeiadi Jordi Sunyer Martine Vrijheid Mariona Bustamante |
| author_facet | Paula de Prado-Bert Carlos Ruiz-Arenas Marta Vives-Usano Sandra Andrusaityte Solène Cadiou Ángel Carracedo Maribel Casas Leda Chatzi Payam Dadvand Juan R. González Regina Grazuleviciene Kristine B. Gutzkow Line S. Haug Carles Hernandez-Ferrer Hector C. Keun Johanna Lepeule Léa Maitre Rosie McEachan Mark J. Nieuwenhuijsen Dolors Pelegrí Oliver Robinson Rémy Slama Marina Vafeiadi Jordi Sunyer Martine Vrijheid Mariona Bustamante |
| author_sort | Paula de Prado-Bert |
| collection | DOAJ |
| description | The early-life exposome influences future health and accelerated biological aging has been proposed as one of the underlying biological mechanisms. We investigated the association between more than 100 exposures assessed during pregnancy and in childhood (including indoor and outdoor air pollutants, built environment, green environments, tobacco smoking, lifestyle exposures, and biomarkers of chemical pollutants), and epigenetic age acceleration in 1,173 children aged 7 years old from the Human Early-Life Exposome project. Age acceleration was calculated based on Horvath’s Skin and Blood clock using child blood DNA methylation measured by Infinium HumanMethylation450 BeadChips. We performed an exposure-wide association study between prenatal and childhood exposome and age acceleration. Maternal tobacco smoking during pregnancy was nominally associated with increased age acceleration. For childhood exposures, indoor particulate matter absorbance (PMabs) and parental smoking were nominally associated with an increase in age acceleration. Exposure to the organic pesticide dimethyl dithiophosphate and the persistent pollutant polychlorinated biphenyl-138 (inversely associated with child body mass index) were protective for age acceleration. None of the associations remained significant after multiple-testing correction. Pregnancy and childhood exposure to tobacco smoke and childhood exposure to indoor PMabs may accelerate epigenetic aging from an early age. |
| first_indexed | 2024-12-20T01:52:08Z |
| format | Article |
| id | doaj.art-f635f2c1861f4ca68035ab490e6b7a03 |
| institution | Directory Open Access Journal |
| issn | 0160-4120 |
| language | English |
| last_indexed | 2024-12-20T01:52:08Z |
| publishDate | 2021-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Environment International |
| spelling | doaj.art-f635f2c1861f4ca68035ab490e6b7a032022-12-21T19:57:37ZengElsevierEnvironment International0160-41202021-10-01155106683The early-life exposome and epigenetic age acceleration in childrenPaula de Prado-Bert0Carlos Ruiz-Arenas1Marta Vives-Usano2Sandra Andrusaityte3Solène Cadiou4Ángel Carracedo5Maribel Casas6Leda Chatzi7Payam Dadvand8Juan R. González9Regina Grazuleviciene10Kristine B. Gutzkow11Line S. Haug12Carles Hernandez-Ferrer13Hector C. Keun14Johanna Lepeule15Léa Maitre16Rosie McEachan17Mark J. Nieuwenhuijsen18Dolors Pelegrí19Oliver Robinson20Rémy Slama21Marina Vafeiadi22Jordi Sunyer23Martine Vrijheid24Mariona Bustamante25ISGlobal, Dr. Aiguader 88, 08003 Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, SpainISGlobal, Dr. Aiguader 88, 08003 Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, SpainISGlobal, Dr. Aiguader 88, 08003 Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, Barcelona 08003, SpainDepartment of Environmental Sciences, Vytautas Magnus University, K. Donelaicio Street 58, 44248 Kaunas, LithuaniaUniversity Grenoble Alpes, Inserm, CNRS, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, IAB, 38000 Grenoble, FranceGrupo de Medicina Xenómica, Fundación Pública Galega de Medicina Xenómica, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), SERGAS, Rúa Choupana s/n, 15706 Santiago de Compostela, Spain; Centro de Investigación en Red de Enfermedades Raras (CIBERER) y Centro Nacional de Genotipado (CEGEN-PRB3-ISCIII), Universidade de Santiago de Compostela, Praza do Obradoiro s/n, 15782 Santiago de Compostela, SpainISGlobal, Dr. Aiguader 88, 08003 Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, SpainDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, USA; Department of Social Medicine, School of Medicine, University of Crete, Heraklion, GreeceISGlobal, Dr. Aiguader 88, 08003 Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, SpainISGlobal, Dr. Aiguader 88, 08003 Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, SpainDepartment of Environmental Sciences, Vytautas Magnus University, K. Donelaicio Street 58, 44248 Kaunas, LithuaniaDepartment of Environmental Health, Norwegian Institute of Public Health, Oslo, NorwayDepartment of Environmental Health, Norwegian Institute of Public Health, Oslo, NorwayISGlobal, Dr. Aiguader 88, 08003 Barcelona, Spain; CNAG-CRG, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Baldiri Reixac 4, Barcelona 08028, SpainDivision of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, South Kensington Campus, London SW7 2AZ, UKUniversity Grenoble Alpes, Inserm, CNRS, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, IAB, 38000 Grenoble, FranceISGlobal, Dr. Aiguader 88, 08003 Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, SpainBradford Institute for Health Research, Bradford Royal Infirmary, Bradford, UKISGlobal, Dr. Aiguader 88, 08003 Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, SpainISGlobal, Dr. Aiguader 88, 08003 Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, SpainMRC Centre for Environment and Health, School of Public Health, Imperial College London, St Marys Hospital Campus, London W21PG, UKUniversity Grenoble Alpes, Inserm, CNRS, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, IAB, 38000 Grenoble, FranceDepartment of Social Medicine, School of Medicine, University of Crete, Heraklion, GreeceISGlobal, Dr. Aiguader 88, 08003 Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, SpainISGlobal, Dr. Aiguader 88, 08003 Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, SpainISGlobal, Dr. Aiguader 88, 08003 Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, Barcelona 08003, Spain; Corresponding author at: ISGlobal, Dr. Aiguader 88, 08003 Barcelona, Spain.The early-life exposome influences future health and accelerated biological aging has been proposed as one of the underlying biological mechanisms. We investigated the association between more than 100 exposures assessed during pregnancy and in childhood (including indoor and outdoor air pollutants, built environment, green environments, tobacco smoking, lifestyle exposures, and biomarkers of chemical pollutants), and epigenetic age acceleration in 1,173 children aged 7 years old from the Human Early-Life Exposome project. Age acceleration was calculated based on Horvath’s Skin and Blood clock using child blood DNA methylation measured by Infinium HumanMethylation450 BeadChips. We performed an exposure-wide association study between prenatal and childhood exposome and age acceleration. Maternal tobacco smoking during pregnancy was nominally associated with increased age acceleration. For childhood exposures, indoor particulate matter absorbance (PMabs) and parental smoking were nominally associated with an increase in age acceleration. Exposure to the organic pesticide dimethyl dithiophosphate and the persistent pollutant polychlorinated biphenyl-138 (inversely associated with child body mass index) were protective for age acceleration. None of the associations remained significant after multiple-testing correction. Pregnancy and childhood exposure to tobacco smoke and childhood exposure to indoor PMabs may accelerate epigenetic aging from an early age.http://www.sciencedirect.com/science/article/pii/S0160412021003081AgingEpigenetic age accelerationPregnancyChildhoodEnvironmental exposures |
| spellingShingle | Paula de Prado-Bert Carlos Ruiz-Arenas Marta Vives-Usano Sandra Andrusaityte Solène Cadiou Ángel Carracedo Maribel Casas Leda Chatzi Payam Dadvand Juan R. González Regina Grazuleviciene Kristine B. Gutzkow Line S. Haug Carles Hernandez-Ferrer Hector C. Keun Johanna Lepeule Léa Maitre Rosie McEachan Mark J. Nieuwenhuijsen Dolors Pelegrí Oliver Robinson Rémy Slama Marina Vafeiadi Jordi Sunyer Martine Vrijheid Mariona Bustamante The early-life exposome and epigenetic age acceleration in children Environment International Aging Epigenetic age acceleration Pregnancy Childhood Environmental exposures |
| title | The early-life exposome and epigenetic age acceleration in children |
| title_full | The early-life exposome and epigenetic age acceleration in children |
| title_fullStr | The early-life exposome and epigenetic age acceleration in children |
| title_full_unstemmed | The early-life exposome and epigenetic age acceleration in children |
| title_short | The early-life exposome and epigenetic age acceleration in children |
| title_sort | early life exposome and epigenetic age acceleration in children |
| topic | Aging Epigenetic age acceleration Pregnancy Childhood Environmental exposures |
| url | http://www.sciencedirect.com/science/article/pii/S0160412021003081 |
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