Biophysics of Tumor Microenvironment and Cancer Metastasis - A Mini Review
The role of tumor microenvironment in cancer progression is gaining significant attention. It is realized that cancer cells and the corresponding stroma co-evolve with time. Cancer cells recruit and transform the stromal cells, which in turn remodel the extra cellular matrix of the stroma. This comp...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2018-01-01
|
| Series: | Computational and Structural Biotechnology Journal |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2001037018300291 |
| _version_ | 1811288326286606336 |
|---|---|
| author | Bashar Emon Jessica Bauer Yasna Jain Barbara Jung Taher Saif |
| author_facet | Bashar Emon Jessica Bauer Yasna Jain Barbara Jung Taher Saif |
| author_sort | Bashar Emon |
| collection | DOAJ |
| description | The role of tumor microenvironment in cancer progression is gaining significant attention. It is realized that cancer cells and the corresponding stroma co-evolve with time. Cancer cells recruit and transform the stromal cells, which in turn remodel the extra cellular matrix of the stroma. This complex interaction between the stroma and the cancer cells results in a dynamic feed-forward/feed-back loop with biochemical and biophysical cues that assist metastatic transition of the cancer cells. Although biochemistry has long been studied for the understanding of cancer progression, biophysical signaling is emerging as a critical paradigm determining cancer metastasis. In this mini review, we discuss the role of one of the biophysical cues, mostly the mechanical stiffness of tumor microenvironment, in cancer progression and its clinical implications. Keywords: Tumor biophysics, Cancer, Metastasis, ECM stiffness, Growth factors, Activin/TGFβ |
| first_indexed | 2024-04-13T03:34:24Z |
| format | Article |
| id | doaj.art-f6365b06cd1c462297a78735b24ad12f |
| institution | Directory Open Access Journal |
| issn | 2001-0370 |
| language | English |
| last_indexed | 2024-04-13T03:34:24Z |
| publishDate | 2018-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Computational and Structural Biotechnology Journal |
| spelling | doaj.art-f6365b06cd1c462297a78735b24ad12f2022-12-22T03:04:22ZengElsevierComputational and Structural Biotechnology Journal2001-03702018-01-0116279287Biophysics of Tumor Microenvironment and Cancer Metastasis - A Mini ReviewBashar Emon0Jessica Bauer1Yasna Jain2Barbara Jung3Taher Saif4Mechanical Science and Engineering, University of Illinois at Urbana-Champaign, United StatesDivision of Gastroenterology and Hepatology, Department of Medicine, University of Illinois at Chicago, United StatesDepartment of Architecture, BRAC University, DhakaDivision of Gastroenterology and Hepatology, Department of Medicine, University of Illinois at Chicago, United StatesMechanical Science and Engineering, University of Illinois at Urbana-Champaign, United States; Bioengineering, University of Illinois at Urbana-Champaign, United States; Corresponding author at: Mechanical Science and Engineering, University of Illinois at Urbana-Champaign, United States.The role of tumor microenvironment in cancer progression is gaining significant attention. It is realized that cancer cells and the corresponding stroma co-evolve with time. Cancer cells recruit and transform the stromal cells, which in turn remodel the extra cellular matrix of the stroma. This complex interaction between the stroma and the cancer cells results in a dynamic feed-forward/feed-back loop with biochemical and biophysical cues that assist metastatic transition of the cancer cells. Although biochemistry has long been studied for the understanding of cancer progression, biophysical signaling is emerging as a critical paradigm determining cancer metastasis. In this mini review, we discuss the role of one of the biophysical cues, mostly the mechanical stiffness of tumor microenvironment, in cancer progression and its clinical implications. Keywords: Tumor biophysics, Cancer, Metastasis, ECM stiffness, Growth factors, Activin/TGFβhttp://www.sciencedirect.com/science/article/pii/S2001037018300291 |
| spellingShingle | Bashar Emon Jessica Bauer Yasna Jain Barbara Jung Taher Saif Biophysics of Tumor Microenvironment and Cancer Metastasis - A Mini Review Computational and Structural Biotechnology Journal |
| title | Biophysics of Tumor Microenvironment and Cancer Metastasis - A Mini Review |
| title_full | Biophysics of Tumor Microenvironment and Cancer Metastasis - A Mini Review |
| title_fullStr | Biophysics of Tumor Microenvironment and Cancer Metastasis - A Mini Review |
| title_full_unstemmed | Biophysics of Tumor Microenvironment and Cancer Metastasis - A Mini Review |
| title_short | Biophysics of Tumor Microenvironment and Cancer Metastasis - A Mini Review |
| title_sort | biophysics of tumor microenvironment and cancer metastasis a mini review |
| url | http://www.sciencedirect.com/science/article/pii/S2001037018300291 |
| work_keys_str_mv | AT basharemon biophysicsoftumormicroenvironmentandcancermetastasisaminireview AT jessicabauer biophysicsoftumormicroenvironmentandcancermetastasisaminireview AT yasnajain biophysicsoftumormicroenvironmentandcancermetastasisaminireview AT barbarajung biophysicsoftumormicroenvironmentandcancermetastasisaminireview AT tahersaif biophysicsoftumormicroenvironmentandcancermetastasisaminireview |