Cyclodextrins as Emerging Therapeutic Tools in the Treatment of Cholesterol-Associated Vascular and Neurodegenerative Diseases

Cyclodextrins as Emerging Therapeutic Tools in the Treatment of Cholesterol-Associated Vascular and Neurodegenerative Diseases

Cardiovascular diseases, like atherosclerosis, and neurodegenerative diseases affecting the central nervous system (CNS) are closely linked to alterations of cholesterol metabolism. Therefore, innovative pharmacological approaches aiming at counteracting cholesterol imbalance display promising thera...

Full description

Bibliographic Details
Main Authors:	Caroline Coisne, Sébastien Tilloy, Eric Monflier, Daniel Wils, Laurence Fenart, Fabien Gosselet
Format:	Article
Language:	English
Published:	MDPI AG 2016-12-01
Series:	Molecules
Subjects:	cyclodextrins cholesterol atherosclerosis neurodegenerative diseases vascular diseases Niemann-Pick disease type C (NPC) Alzheimer’s disease (AD) blood-brain barrier (BBB) HPβCD KLEPTOSE® CRYSMEB
Online Access:	http://www.mdpi.com/1420-3049/21/12/1748

Similar Items

Different solubilizing ability of cyclodextrin derivatives for cholesterol in Niemann–Pick disease type C treatment
by: Yusei Yamada, et al.
Published: (2023-08-01)

Molecular Mind Games: The Medicinal Action of Cyclodextrins in Neurodegenerative Diseases
by: Susana Santos Braga
Published: (2023-04-01)

Cholesterol lowering effects of mono-lactose-appended β-cyclodextrin in Niemann–Pick type C disease-like HepG2 cells
by: Keiichi Motoyama, et al.
Published: (2015-11-01)

Synthesis of multi-lactose-appended β-cyclodextrin and its cholesterol-lowering effects in Niemann–Pick type C disease-like HepG2 cells
by: Keiichi Motoyama, et al.
Published: (2017-01-01)

Case Report: Be Aware of “New” Features of Niemann–Pick Disease: Insights From Two Pediatric Cases
by: Fan Chen, et al.
Published: (2022-03-01)

Long-term administration of intravenous Trappsol® Cyclo™ (HP-β-CD) results in clinical benefits and stabilization or slowing of disease progression in patients with Niemann-Pick disease type C1: Results of an international 48-week Phase I/II trial
by: Reena Sharma, et al.
Published: (2023-09-01)

Fine-tuned cholesterol solubilizer, mono-6-O-α-D-maltosyl-γ-cyclodextrin, ameliorates experimental Niemann–Pick disease type C without hearing loss
by: Yusei Yamada, et al.
Published: (2022-11-01)

Phenotype assessment for neurodegenerative murine models with ataxia and application to Niemann–Pick disease, type C1
by: Julia Yerger, et al.
Published: (2022-04-01)

Compound heterozygous Niemann-Pick Type C disease in the neonatal period
by: Özden Turan, et al.
Published: (2021-09-01)

Niemann Peak Disease Type A in Necropsy of the Liver of a Four-Month-Old Female with Fe-ver and Pancytopenia
by: Amer Yazdanparast, et al.
Published: (2021-05-01)

Cyclodextrins and Iatrogenic Hearing Loss: New Drugs with Significant Risk
by: Mark A. Crumling, et al.
Published: (2017-11-01)

Pediatric hepatocellular carcinoma associated with Niemann–Pick disease type C: Case report and literature review
by: Soojin Hwang, et al.
Published: (2023-01-01)

Target lysis by cholesterol extraction is a rate limiting step in the resolution of phagolysosomes
by: Dante Barreda, et al.
Published: (2024-03-01)

Favorable outcomes following early onset oral miglustat in early infantile Niemann Pick Type C
by: Shiri Curelaru, et al.
Published: (2021-06-01)

Lysosomal membrane glycoproteins bind cholesterol and contribute to lysosomal cholesterol export
by: Jian Li, et al.
Published: (2016-09-01)

Effects of Hydroxypropyl-Beta-Cyclodextrin on Cultured Brain Endothelial Cells
by: Szilvia Veszelka, et al.
Published: (2022-11-01)

The Genetic Basis, Lung Involvement, and Therapeutic Options in Niemann–Pick Disease: A Comprehensive Review
by: Claudio Tirelli, et al.
Published: (2024-02-01)

Novel NPC1 mutations with different segregation in two related Greek patients with Niemann-Pick type C disease: molecular study in the extended pedigree and clinical correlations
by: Evangelia Bountouvi, et al.
Published: (2017-05-01)

Phenotypic variability of Niemann-Pick disease type C including a case with clinically pure schizophrenia: a case report
by: Tomoya Kawazoe, et al.
Published: (2018-08-01)

Adult‐onset Niemann–Pick disease type C masquerading as spinocerebellar ataxia
by: Mary L. Vo, et al.
Published: (2022-04-01)

Intracellular cholesterol trafficking is dependent upon NPC2 interaction with lysobisphosphatidic acid
by: Leslie A McCauliff, et al.
Published: (2019-10-01)

Bidirectional links between Alzheimer's disease and Niemann–Pick type C disease
by: Martina Malnar, et al.
Published: (2014-12-01)

Brain hypometabolism in rare genetic neurodegenerative disease: Niemann-Pick disease type C, spinocerebellar ataxia and Huntington disease assessed by FDG PET
by: Yung Hsiang Kao, et al.
Published: (2021-07-01)

Anti-TNF therapy for inflammatory bowel disease in patients with neurodegenerative Niemann-Pick disease Type C [version 1; peer review: 2 approved]
by: David Smith, et al.
Published: (2022-01-01)

Priapism associated with Niemann-Pick disease in a 15-year-old boy
by: M V Krishna Shetty, et al.
Published: (2011-01-01)

Heat shock protein amplification improves cerebellar myelination in the Npc1nih mouse modelResearch in context
by: James Gray, et al.
Published: (2022-12-01)

Treatment outcomes following continuous miglustat therapy in patients with Niemann-Pick disease Type C: a final report of the NPC Registry
by: Marc C. Patterson, et al.
Published: (2020-04-01)

Genetic background modifies phenotypic severity and longevity in a mouse model of Niemann-Pick disease type C1
by: Jorge L. Rodriguez-Gil, et al.
Published: (2020-03-01)

Intracerebroventricular Treatment with 2-Hydroxypropyl-β-Cyclodextrin Decreased Cerebellar and Hepatic Glycoprotein Nonmetastatic Melanoma Protein B (GPNMB) Expression in Niemann–Pick Disease Type C Model Mice
by: Madoka Fukaura, et al.
Published: (2021-01-01)

Membrane topology of human NPC1L1, a key protein in enterohepatic cholesterol absorption
by: Jiang Wang, et al.
Published: (2009-08-01)

The Potential of Cyclodextrins as Novel Active Pharmaceutical Ingredients: A Short Overview
by: Massimiliano Pio di Cagno
Published: (2016-12-01)

Niemann Pick disease: a rare lysosomal storage disease
by: Gopen Kumar Kundu, et al.
Published: (2023-01-01)

Overlapping Neuroimmune Mechanisms and Therapeutic Targets in Neurodegenerative Disorders
by: Fabiola De Marchi, et al.
Published: (2023-10-01)

The susceptibility of cochlear outer hair cells to cyclodextrin is not related to their electromotile activity
by: Yingjie Zhou, et al.
Published: (2018-09-01)

Consensus clinical management guidelines for Niemann-Pick disease type C
by: Tarekegn Geberhiwot, et al.
Published: (2018-04-01)

Inhibitory Effect of Isoliquiritigenin in Niemann-Pick C1-Like 1-Mediated Cholesterol Uptake
by: Jun Zeng, et al.
Published: (2022-11-01)

Novel compound heterozygous mutations of the NPC1 gene associated with Niemann-pick disease type C: a case report and review of the literature
by: Chaoxin Tao, et al.
Published: (2024-01-01)

NPC1 Deficiency Contributes to Autophagy-Dependent Ferritinophagy in HEI-OC1 Auditory Cells
by: Lihong Liang, et al.
Published: (2022-07-01)

Dental Treatment of Two Children with Niemann Pick Disease Type B Under General Anesthesia: Case Reports
by: Mustafa Sarp KAYA, et al.
Published: (2019-01-01)

Quantitative role of LAL, NPC2, and NPC1 in lysosomal cholesterol processing defined by genetic and pharmacological manipulations
by: Charina M. Ramirez, et al.
Published: (2011-04-01)