Methods of the Analysis of Oxylipins in Biological Samples
Oxylipins are derivatives of polyunsaturated fatty acids and due to their important and diverse functions in the body, they have become a popular subject of studies. The main challenge for researchers is their low stability and often very low concentration in samples. Therefore, in recent years ther...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-01-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/2/349 |
| _version_ | 1819226518653501440 |
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| author | Ivan Liakh Alicja Pakiet Tomasz Sledzinski Adriana Mika |
| author_facet | Ivan Liakh Alicja Pakiet Tomasz Sledzinski Adriana Mika |
| author_sort | Ivan Liakh |
| collection | DOAJ |
| description | Oxylipins are derivatives of polyunsaturated fatty acids and due to their important and diverse functions in the body, they have become a popular subject of studies. The main challenge for researchers is their low stability and often very low concentration in samples. Therefore, in recent years there have been developments in the extraction and analysis methods of oxylipins. New approaches in extraction methods were described in our previous review. In turn, the old analysis methods have been replaced by new approaches based on mass spectrometry (MS) coupled with liquid chromatography (LC) and gas chromatography (GC), and the best of these methods allow hundreds of oxylipins to be quantitatively identified. This review presents comparative and comprehensive information on the progress of various methods used by various authors to achieve the best results in the analysis of oxylipins in biological samples. |
| first_indexed | 2024-12-23T10:26:46Z |
| format | Article |
| id | doaj.art-f63773e9c4d043e89da0ff6fc7b29c35 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-23T10:26:46Z |
| publishDate | 2020-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-f63773e9c4d043e89da0ff6fc7b29c352022-12-21T17:50:33ZengMDPI AGMolecules1420-30492020-01-0125234910.3390/molecules25020349molecules25020349Methods of the Analysis of Oxylipins in Biological SamplesIvan Liakh0Alicja Pakiet1Tomasz Sledzinski2Adriana Mika3Department of Pharmaceutical Biochemistry, Medical University of Gdansk, Debinki 1, 80-211 Gdansk, PolandDepartment of Environmental Analysis, Faculty of Chemistry, University of Gdansk, Wita Stwosza 63, 80-308 Gdansk, PolandDepartment of Pharmaceutical Biochemistry, Medical University of Gdansk, Debinki 1, 80-211 Gdansk, PolandDepartment of Pharmaceutical Biochemistry, Medical University of Gdansk, Debinki 1, 80-211 Gdansk, PolandOxylipins are derivatives of polyunsaturated fatty acids and due to their important and diverse functions in the body, they have become a popular subject of studies. The main challenge for researchers is their low stability and often very low concentration in samples. Therefore, in recent years there have been developments in the extraction and analysis methods of oxylipins. New approaches in extraction methods were described in our previous review. In turn, the old analysis methods have been replaced by new approaches based on mass spectrometry (MS) coupled with liquid chromatography (LC) and gas chromatography (GC), and the best of these methods allow hundreds of oxylipins to be quantitatively identified. This review presents comparative and comprehensive information on the progress of various methods used by various authors to achieve the best results in the analysis of oxylipins in biological samples.https://www.mdpi.com/1420-3049/25/2/349oxylipinsbiological sampleshplcuhplcgc–mslc–ms |
| spellingShingle | Ivan Liakh Alicja Pakiet Tomasz Sledzinski Adriana Mika Methods of the Analysis of Oxylipins in Biological Samples Molecules oxylipins biological samples hplc uhplc gc–ms lc–ms |
| title | Methods of the Analysis of Oxylipins in Biological Samples |
| title_full | Methods of the Analysis of Oxylipins in Biological Samples |
| title_fullStr | Methods of the Analysis of Oxylipins in Biological Samples |
| title_full_unstemmed | Methods of the Analysis of Oxylipins in Biological Samples |
| title_short | Methods of the Analysis of Oxylipins in Biological Samples |
| title_sort | methods of the analysis of oxylipins in biological samples |
| topic | oxylipins biological samples hplc uhplc gc–ms lc–ms |
| url | https://www.mdpi.com/1420-3049/25/2/349 |
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