Dissolving Candlelit Microneedle for Chronic Inflammatory Skin Diseases
Abstract Chronic inflammatory skin diseases (CISDs) negatively impact a large number of patients. Injection of triamcinolone acetonide (TA), an anti‐inflammatory steroid drug, directly into the dermis of diseased skin using needle‐syringe systems is a long‐established procedure for treating recalcit...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-07-01
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| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.202004873 |
| _version_ | 1818588807854817280 |
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| author | Jungyoon Ohn Mingyu Jang Bo Mi Kang Huisuk Yang Jin Tae Hong Kyu Han Kim Ohsang Kwon Hyungil Jung |
| author_facet | Jungyoon Ohn Mingyu Jang Bo Mi Kang Huisuk Yang Jin Tae Hong Kyu Han Kim Ohsang Kwon Hyungil Jung |
| author_sort | Jungyoon Ohn |
| collection | DOAJ |
| description | Abstract Chronic inflammatory skin diseases (CISDs) negatively impact a large number of patients. Injection of triamcinolone acetonide (TA), an anti‐inflammatory steroid drug, directly into the dermis of diseased skin using needle‐syringe systems is a long‐established procedure for treating recalcitrant lichenified lesions of CISDs, referred to as TA intralesional injection (TAILI). However, TAILI causes severe pain, causing patients to be stressed and reluctant to undergo treatment. Furthermore, the practitioner dependency on the amount and depth of the injected TA makes it difficult to predict the prognosis. Here, candle flame (“candlelit”)‐shaped TA‐loaded dissolving microneedles (Candlelit‐DMN) are designed and fabricated out of biocompatible and biodegradable molecules. Candlelit‐DMN distributes TA evenly across human skin tissue. Conjoined with the applicator, Candlelit‐DMN is efficiently inserted into human skin in a standardized manner, enabling TA to be delivered within the target layer. In an in vivo skin inflammation mouse model, Candlelit‐DMN inserted with the applicator effectively alleviates inflammation by suppressing inflammatory cell infiltration and cytokine gene expression, to the same extent as TAILI. This Candlelit‐DMN with the applicator arouses the interest of dermatologists, who prefer it to the current TAILI procedure. |
| first_indexed | 2024-12-16T09:30:38Z |
| format | Article |
| id | doaj.art-f638a2a3f7e141ca925a75959b1f8ffd |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-12-16T09:30:38Z |
| publishDate | 2021-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-f638a2a3f7e141ca925a75959b1f8ffd2022-12-21T22:36:32ZengWileyAdvanced Science2198-38442021-07-01814n/an/a10.1002/advs.202004873Dissolving Candlelit Microneedle for Chronic Inflammatory Skin DiseasesJungyoon Ohn0Mingyu Jang1Bo Mi Kang2Huisuk Yang3Jin Tae Hong4Kyu Han Kim5Ohsang Kwon6Hyungil Jung7Department of Dermatology Seoul National University College of Medicine Seoul 03080 Republic of KoreaDepartment of Biotechnology Yonsei University 50 Yonsei‐ro Seoul 03722 Republic of KoreaDepartment of Dermatology Seoul National University College of Medicine Seoul 03080 Republic of KoreaJUVIC Inc. 272 Digital‐ro Seoul 08389 Republic of KoreaJUVIC Inc. 272 Digital‐ro Seoul 08389 Republic of KoreaDepartment of Dermatology Seoul National University College of Medicine Seoul 03080 Republic of KoreaDepartment of Dermatology Seoul National University College of Medicine Seoul 03080 Republic of KoreaDepartment of Biotechnology Yonsei University 50 Yonsei‐ro Seoul 03722 Republic of KoreaAbstract Chronic inflammatory skin diseases (CISDs) negatively impact a large number of patients. Injection of triamcinolone acetonide (TA), an anti‐inflammatory steroid drug, directly into the dermis of diseased skin using needle‐syringe systems is a long‐established procedure for treating recalcitrant lichenified lesions of CISDs, referred to as TA intralesional injection (TAILI). However, TAILI causes severe pain, causing patients to be stressed and reluctant to undergo treatment. Furthermore, the practitioner dependency on the amount and depth of the injected TA makes it difficult to predict the prognosis. Here, candle flame (“candlelit”)‐shaped TA‐loaded dissolving microneedles (Candlelit‐DMN) are designed and fabricated out of biocompatible and biodegradable molecules. Candlelit‐DMN distributes TA evenly across human skin tissue. Conjoined with the applicator, Candlelit‐DMN is efficiently inserted into human skin in a standardized manner, enabling TA to be delivered within the target layer. In an in vivo skin inflammation mouse model, Candlelit‐DMN inserted with the applicator effectively alleviates inflammation by suppressing inflammatory cell infiltration and cytokine gene expression, to the same extent as TAILI. This Candlelit‐DMN with the applicator arouses the interest of dermatologists, who prefer it to the current TAILI procedure.https://doi.org/10.1002/advs.202004873candlelit microneedleschronic inflammatory skin diseasesdissolving microneedlestriamcinolone acetonide |
| spellingShingle | Jungyoon Ohn Mingyu Jang Bo Mi Kang Huisuk Yang Jin Tae Hong Kyu Han Kim Ohsang Kwon Hyungil Jung Dissolving Candlelit Microneedle for Chronic Inflammatory Skin Diseases Advanced Science candlelit microneedles chronic inflammatory skin diseases dissolving microneedles triamcinolone acetonide |
| title | Dissolving Candlelit Microneedle for Chronic Inflammatory Skin Diseases |
| title_full | Dissolving Candlelit Microneedle for Chronic Inflammatory Skin Diseases |
| title_fullStr | Dissolving Candlelit Microneedle for Chronic Inflammatory Skin Diseases |
| title_full_unstemmed | Dissolving Candlelit Microneedle for Chronic Inflammatory Skin Diseases |
| title_short | Dissolving Candlelit Microneedle for Chronic Inflammatory Skin Diseases |
| title_sort | dissolving candlelit microneedle for chronic inflammatory skin diseases |
| topic | candlelit microneedles chronic inflammatory skin diseases dissolving microneedles triamcinolone acetonide |
| url | https://doi.org/10.1002/advs.202004873 |
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