Effects of pre-medication with acepromazine/midazolam/ dexmedetomidine and butorphanol on induction dose of propofol and incidence of apnoea during induction in canines
The objective of the study was to evaluate the effect of ACE, MID, DEX (IM) and DEX (IV) with butorphanol on quality of induction, induction dose of propofol and incidence of apnoea during anaesthesia in client-owned dogs. Animals were randomly divided into four groups. After pre-medication with at...
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| Format: | Article |
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Indian Council of Agricultural Research
2022-09-01
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| Series: | Indian Journal of Animal Sciences |
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| Online Access: | https://epubs.icar.org.in/index.php/IJAnS/article/view/124473 |
| _version_ | 1811169136925999104 |
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| author | RAJESH KUMAR AAKANKSHA RAMESH TIWARY N K VERMA A C SAXENA M HOQUE |
| author_facet | RAJESH KUMAR AAKANKSHA RAMESH TIWARY N K VERMA A C SAXENA M HOQUE |
| author_sort | RAJESH KUMAR |
| collection | DOAJ |
| description |
The objective of the study was to evaluate the effect of ACE, MID, DEX (IM) and DEX (IV) with butorphanol on quality of induction, induction dose of propofol and incidence of apnoea during anaesthesia in client-owned dogs. Animals were randomly divided into four groups. After pre-medication with atropine sulphate, animals were administered with ACE @ 0.05 mg/kg b.wt IV in group A, MID @ 0.5 mg/kg IV b.wt in group B, DEX @ 15 μg/kg IM b.wt in group C and DEX @ 15 μg/kg IV b.wt in group D along with butorphanol @ 0.2 mg/kg b. wt. I/V. All animals were induced with propofol and maintained with isoflurane till the end of closing last skin suture. Adequate sedation and depth of analgesia was observed in the animals of the all four group and this sedation made handling of the animals proper and safe before induction. Significantly lower dose of propofol was needed for induction in the grous C and D as compared to groups A and B. Incidence of temporary apnoea in groups A and B was 10%, whereas in groups C and D was 30%, but they were managed by assisted ventilation and smoothly maintained with isoflurane without complication. It was found that ACE/MID/DEX with butorphanol has dose-sparing effect and provides adequate sedation and analgesia in the canines. Chances of apnoea may be more with DEX pre-medication, but they can be managed by assisted ventilation without any complication.
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| first_indexed | 2024-04-10T16:37:20Z |
| format | Article |
| id | doaj.art-f63937db2e244ddcbdeeb02a7e4b7123 |
| institution | Directory Open Access Journal |
| issn | 0367-8318 2394-3327 |
| language | English |
| last_indexed | 2024-04-10T16:37:20Z |
| publishDate | 2022-09-01 |
| publisher | Indian Council of Agricultural Research |
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| series | Indian Journal of Animal Sciences |
| spelling | doaj.art-f63937db2e244ddcbdeeb02a7e4b71232023-02-08T11:22:56ZengIndian Council of Agricultural ResearchIndian Journal of Animal Sciences0367-83182394-33272022-09-0192910.56093/ijans.v92i9.124473Effects of pre-medication with acepromazine/midazolam/ dexmedetomidine and butorphanol on induction dose of propofol and incidence of apnoea during induction in caninesRAJESH KUMAR0AAKANKSHA1RAMESH TIWARY2N K VERMA3A C SAXENA4M HOQUE5Indian Veterinary Research InstituteDivision of Surgery, ICARIVRI, Izatnagar, Bareilly, Uttar PradeshDivision of Surgery, ICARIVRI, Izatnagar, Bareilly, Uttar PradeshDivision of Surgery, ICARIVRI, Izatnagar, Bareilly, Uttar Pradesh.Division of Surgery, ICARIVRI, Izatnagar, Bareilly, Uttar PradeshDivision of Surgery, ICARIVRI, Izatnagar, Bareilly, Uttar Pradesh The objective of the study was to evaluate the effect of ACE, MID, DEX (IM) and DEX (IV) with butorphanol on quality of induction, induction dose of propofol and incidence of apnoea during anaesthesia in client-owned dogs. Animals were randomly divided into four groups. After pre-medication with atropine sulphate, animals were administered with ACE @ 0.05 mg/kg b.wt IV in group A, MID @ 0.5 mg/kg IV b.wt in group B, DEX @ 15 μg/kg IM b.wt in group C and DEX @ 15 μg/kg IV b.wt in group D along with butorphanol @ 0.2 mg/kg b. wt. I/V. All animals were induced with propofol and maintained with isoflurane till the end of closing last skin suture. Adequate sedation and depth of analgesia was observed in the animals of the all four group and this sedation made handling of the animals proper and safe before induction. Significantly lower dose of propofol was needed for induction in the grous C and D as compared to groups A and B. Incidence of temporary apnoea in groups A and B was 10%, whereas in groups C and D was 30%, but they were managed by assisted ventilation and smoothly maintained with isoflurane without complication. It was found that ACE/MID/DEX with butorphanol has dose-sparing effect and provides adequate sedation and analgesia in the canines. Chances of apnoea may be more with DEX pre-medication, but they can be managed by assisted ventilation without any complication. https://epubs.icar.org.in/index.php/IJAnS/article/view/124473Acepromazine, Apnoea, Dexmedetomidine, Induction, Midazolam, Propofol |
| spellingShingle | RAJESH KUMAR AAKANKSHA RAMESH TIWARY N K VERMA A C SAXENA M HOQUE Effects of pre-medication with acepromazine/midazolam/ dexmedetomidine and butorphanol on induction dose of propofol and incidence of apnoea during induction in canines Indian Journal of Animal Sciences Acepromazine, Apnoea, Dexmedetomidine, Induction, Midazolam, Propofol |
| title | Effects of pre-medication with acepromazine/midazolam/ dexmedetomidine and butorphanol on induction dose of propofol and incidence of apnoea during induction in canines |
| title_full | Effects of pre-medication with acepromazine/midazolam/ dexmedetomidine and butorphanol on induction dose of propofol and incidence of apnoea during induction in canines |
| title_fullStr | Effects of pre-medication with acepromazine/midazolam/ dexmedetomidine and butorphanol on induction dose of propofol and incidence of apnoea during induction in canines |
| title_full_unstemmed | Effects of pre-medication with acepromazine/midazolam/ dexmedetomidine and butorphanol on induction dose of propofol and incidence of apnoea during induction in canines |
| title_short | Effects of pre-medication with acepromazine/midazolam/ dexmedetomidine and butorphanol on induction dose of propofol and incidence of apnoea during induction in canines |
| title_sort | effects of pre medication with acepromazine midazolam dexmedetomidine and butorphanol on induction dose of propofol and incidence of apnoea during induction in canines |
| topic | Acepromazine, Apnoea, Dexmedetomidine, Induction, Midazolam, Propofol |
| url | https://epubs.icar.org.in/index.php/IJAnS/article/view/124473 |
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