Association of urinary cotinine-verified smoking status with hyperuricemia: Analysis of population-based nationally representative data
Introduction Smoking status based solely on self-reporting is unreliable and might be inaccurate, particularly among women. This study investigated the association between urinary cotinine-verified smoking status and hyperuricemia in a nationwide Korean population. Methods This study included 5,329...
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| Format: | Article |
| Language: | English |
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European Publishing
2020-10-01
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| Series: | Tobacco Induced Diseases |
| Subjects: | |
| Online Access: | http://www.journalssystem.com/tid/Association-of-urinary-cotinine-verified-smoking-status-with-hyperuricemia-An-analysis,127269,0,2.html |
| _version_ | 1818345250238758912 |
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| author | Yunkyung Kim Jihun Kang |
| author_facet | Yunkyung Kim Jihun Kang |
| author_sort | Yunkyung Kim |
| collection | DOAJ |
| description | Introduction
Smoking status based solely on self-reporting is unreliable and might be inaccurate, particularly among women. This study investigated the association between urinary cotinine-verified smoking status and hyperuricemia in a nationwide Korean population.
Methods
This study included 5,329 participants aged ≥19 years with information on smoking status, urine cotinine levels and serum uric acid. We determined smoking status according to self-reports and urinary cotinine levels. Multivariate linear regression analysis was used to measure the association between smoking exposure and serum uric acid levels. The effects of smoking on hyperuricemia were evaluated by multivariate logistic regression analysis.
Results
Biochemically-verified active and passive smokers comprised 22% (38.7% of men and 8.8% of women) and 12.3% (11.9% of men and 12.6% of women) of the study population, respectively. While reclassification rate of active smokers was 1.4% in men, 31.8% of cotinine-verified female active smokers were self-reported never smokers. Higher uric acid levels were observed with increased tobacco exposure among women (P trend = 0.007) but not among men. After adjusting for confounders, the risk of hyperuricemia increased with tobacco exposure only in women (P trend = 0.016).
Conclusions
Cotinine-verified smoking status was associated with increased serum uric acid and hyperuricemia in a dose-response manner only in women. This study might provide evidence to support the importance of smoking cessation in women with gout and further studies are necessary to elucidate the underlying mechanism of the observed association. |
| first_indexed | 2024-12-13T16:59:23Z |
| format | Article |
| id | doaj.art-f63958e289db4b91b2c308d6c8e8eb7d |
| institution | Directory Open Access Journal |
| issn | 1617-9625 |
| language | English |
| last_indexed | 2024-12-13T16:59:23Z |
| publishDate | 2020-10-01 |
| publisher | European Publishing |
| record_format | Article |
| series | Tobacco Induced Diseases |
| spelling | doaj.art-f63958e289db4b91b2c308d6c8e8eb7d2022-12-21T23:37:51ZengEuropean PublishingTobacco Induced Diseases1617-96252020-10-0118October11010.18332/tid/127269127269Association of urinary cotinine-verified smoking status with hyperuricemia: Analysis of population-based nationally representative dataYunkyung Kim0Jihun Kang1Department of Rheumatology, Kosin University Gospel Hospital, Kosin University, Busan, Republic of KoreaDepartment of Family Medicine, Kosin University Gospel Hospital, Kosin University, Busan, Republic of KoreaIntroduction Smoking status based solely on self-reporting is unreliable and might be inaccurate, particularly among women. This study investigated the association between urinary cotinine-verified smoking status and hyperuricemia in a nationwide Korean population. Methods This study included 5,329 participants aged ≥19 years with information on smoking status, urine cotinine levels and serum uric acid. We determined smoking status according to self-reports and urinary cotinine levels. Multivariate linear regression analysis was used to measure the association between smoking exposure and serum uric acid levels. The effects of smoking on hyperuricemia were evaluated by multivariate logistic regression analysis. Results Biochemically-verified active and passive smokers comprised 22% (38.7% of men and 8.8% of women) and 12.3% (11.9% of men and 12.6% of women) of the study population, respectively. While reclassification rate of active smokers was 1.4% in men, 31.8% of cotinine-verified female active smokers were self-reported never smokers. Higher uric acid levels were observed with increased tobacco exposure among women (P trend = 0.007) but not among men. After adjusting for confounders, the risk of hyperuricemia increased with tobacco exposure only in women (P trend = 0.016). Conclusions Cotinine-verified smoking status was associated with increased serum uric acid and hyperuricemia in a dose-response manner only in women. This study might provide evidence to support the importance of smoking cessation in women with gout and further studies are necessary to elucidate the underlying mechanism of the observed association.http://www.journalssystem.com/tid/Association-of-urinary-cotinine-verified-smoking-status-with-hyperuricemia-An-analysis,127269,0,2.htmluric acidhyperuricemiacotininesmokingknhanes |
| spellingShingle | Yunkyung Kim Jihun Kang Association of urinary cotinine-verified smoking status with hyperuricemia: Analysis of population-based nationally representative data Tobacco Induced Diseases uric acid hyperuricemia cotinine smoking knhanes |
| title | Association of urinary cotinine-verified smoking status with
hyperuricemia: Analysis of population-based nationally
representative data |
| title_full | Association of urinary cotinine-verified smoking status with
hyperuricemia: Analysis of population-based nationally
representative data |
| title_fullStr | Association of urinary cotinine-verified smoking status with
hyperuricemia: Analysis of population-based nationally
representative data |
| title_full_unstemmed | Association of urinary cotinine-verified smoking status with
hyperuricemia: Analysis of population-based nationally
representative data |
| title_short | Association of urinary cotinine-verified smoking status with
hyperuricemia: Analysis of population-based nationally
representative data |
| title_sort | association of urinary cotinine verified smoking status with hyperuricemia analysis of population based nationally representative data |
| topic | uric acid hyperuricemia cotinine smoking knhanes |
| url | http://www.journalssystem.com/tid/Association-of-urinary-cotinine-verified-smoking-status-with-hyperuricemia-An-analysis,127269,0,2.html |
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