The yeast H+-ATPase Pma1 promotes Rag/Gtr-dependent TORC1 activation in response to H+-coupled nutrient uptake

The yeast H+-ATPase Pma1 promotes Rag/Gtr-dependent TORC1 activation in response to H+-coupled nutrient uptake

The yeast Target of Rapamycin Complex 1 (TORC1) plays a central role in controlling growth. How amino acids and other nutrients stimulate its activity via the Rag/Gtr GTPases remains poorly understood. We here report that the signal triggering Rag/Gtr-dependent TORC1 activation upon amino-acid uptak...

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Bibliographic Details
Main Authors: Elie Saliba, Minoas Evangelinos, Christos Gournas, Florent Corrillon, Isabelle Georis, Bruno André
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-03-01
Series:eLife
Subjects:
nutrient signaling
TORC1
H+-ATPase
membrane transport
yeast
Online Access:https://elifesciences.org/articles/31981

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