Acetate ameliorates ovarian mitochondrial dysfunction in letrozole-induced polycystic ovarian syndrome rat model by improving mitofusin-2

Acetate ameliorates ovarian mitochondrial dysfunction in letrozole-induced polycystic ovarian syndrome rat model by improving mitofusin-2

Abstract Androgen excess and metabolic abnormality largely contribute to the pathogenesis of polycystic ovarian syndrome (PCOS), which primarily precipitates ovarian dysfunction and infertility in reproductive-age women. Impaired mitochondrial function and epigenetic alteration have been linked to t...

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Bibliographic Details
Main Authors: Kehinde S. Olaniyi, Stephanie E. Areloegbe
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Journal of Physiological Sciences
Subjects:
Androgen
HDAC2
Infertility
Mitochondrial dysfunction
Mitofusin-2
PCOS
Online Access:https://doi.org/10.1186/s12576-024-00908-5

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