WNT signaling memory is required for ACTIVIN to function as a morphogen in human gastruloids

WNT signaling memory is required for ACTIVIN to function as a morphogen in human gastruloids

Self-organization of discrete fates in human gastruloids is mediated by a hierarchy of signaling pathways. How these pathways are integrated in time, and whether cells maintain a memory of their signaling history remains obscure. Here, we dissect the temporal integration of two key pathways, WNT and...

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Bibliographic Details
Main Authors: Anna Yoney, Fred Etoc, Albert Ruzo, Thomas Carroll, Jakob J Metzger, Iain Martyn, Shu Li, Christoph Kirst, Eric D Siggia, Ali H Brivanlou
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-10-01
Series:eLife
Subjects:
Pluripotent stem cells
mesendoderm differentiation
micropatterns
SMAD signaling
live imaging
WNT
Online Access:https://elifesciences.org/articles/38279

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