Distribution of inflammatory phenotypes among patients with asthma in Jilin Province, China: a cross-sectional study
Abstract Background The inflammatory phenotypes of asthma predict the treatment response and prognosis. The phenotype distributions differ depending on the geographical region. This study aimed to assess the distribution of different inflammatory phenotypes among asthma patients in Jilin Province, C...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-11-01
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| Series: | BMC Pulmonary Medicine |
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| Online Access: | https://doi.org/10.1186/s12890-021-01722-0 |
| _version_ | 1828146626557902848 |
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| author | Bingqing Shi Wei Li Hongna Dong Mengting Xu Yuqiu Hao Peng Gao |
| author_facet | Bingqing Shi Wei Li Hongna Dong Mengting Xu Yuqiu Hao Peng Gao |
| author_sort | Bingqing Shi |
| collection | DOAJ |
| description | Abstract Background The inflammatory phenotypes of asthma predict the treatment response and prognosis. The phenotype distributions differ depending on the geographical region. This study aimed to assess the distribution of different inflammatory phenotypes among asthma patients in Jilin Province, China. Methods A total of 255 patients with asthma were recruited from Jilin Province, China for this cross-sectional study. Each patient underwent sputum induction following clinical assessment and peripheral blood collection. Inflammatory phenotypes were classified according to the inflammatory cell counts in the sputum. Results Paucigranulocytic asthma (PGA) was the most common inflammatory phenotype (52.2%), followed by eosinophilic asthma (EA, 38.3%), mixed granulocytic asthma (MGA, 5.2%), and neutrophilic asthma (NA, 4.3%). NA was more common among patients over 45 years old and those who were treated with higher doses of inhaled corticosteroids (ICS), but was less common following antibiotics treatment (p < 0.05). The proportion of patients with EA decreased as the ICS treatment dose and time increased (p = 0.038). Patients with uncontrolled asthma had higher numbers of sputum eosinophils and neutrophils (p < 0.05). Patients with severe asthma had a higher percentage of sputum neutrophils (p < 0.05). A greater proportion of patients with NA had severe asthma (60%) compared to those with EA (18.2%) (p = 0.016). Conclusions The most common asthma inflammatory cell phenotype in Jilin Province, China is PGA, followed by EA, MGA, and NA. The low prevalence of NA in Jilin Province compared to other countries and also other regions in China might be due to excessive antibiotic use and irregular ICS treatment in this region. |
| first_indexed | 2024-04-11T20:49:38Z |
| format | Article |
| id | doaj.art-f63d141dc41743698bfd7c4d2a993c94 |
| institution | Directory Open Access Journal |
| issn | 1471-2466 |
| language | English |
| last_indexed | 2024-04-11T20:49:38Z |
| publishDate | 2021-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pulmonary Medicine |
| spelling | doaj.art-f63d141dc41743698bfd7c4d2a993c942022-12-22T04:03:53ZengBMCBMC Pulmonary Medicine1471-24662021-11-0121111110.1186/s12890-021-01722-0Distribution of inflammatory phenotypes among patients with asthma in Jilin Province, China: a cross-sectional studyBingqing Shi0Wei Li1Hongna Dong2Mengting Xu3Yuqiu Hao4Peng Gao5Department of Respiratory Medicine, The Second Hospital of Jilin UniversityDepartment of Respiratory Medicine, The Second Hospital of Jilin UniversityDepartment of Respiratory Medicine, The Second Hospital of Jilin UniversityDepartment of Respiratory Medicine, The Second Hospital of Jilin UniversityDepartment of Respiratory Medicine, The Second Hospital of Jilin UniversityDepartment of Respiratory Medicine, The Second Hospital of Jilin UniversityAbstract Background The inflammatory phenotypes of asthma predict the treatment response and prognosis. The phenotype distributions differ depending on the geographical region. This study aimed to assess the distribution of different inflammatory phenotypes among asthma patients in Jilin Province, China. Methods A total of 255 patients with asthma were recruited from Jilin Province, China for this cross-sectional study. Each patient underwent sputum induction following clinical assessment and peripheral blood collection. Inflammatory phenotypes were classified according to the inflammatory cell counts in the sputum. Results Paucigranulocytic asthma (PGA) was the most common inflammatory phenotype (52.2%), followed by eosinophilic asthma (EA, 38.3%), mixed granulocytic asthma (MGA, 5.2%), and neutrophilic asthma (NA, 4.3%). NA was more common among patients over 45 years old and those who were treated with higher doses of inhaled corticosteroids (ICS), but was less common following antibiotics treatment (p < 0.05). The proportion of patients with EA decreased as the ICS treatment dose and time increased (p = 0.038). Patients with uncontrolled asthma had higher numbers of sputum eosinophils and neutrophils (p < 0.05). Patients with severe asthma had a higher percentage of sputum neutrophils (p < 0.05). A greater proportion of patients with NA had severe asthma (60%) compared to those with EA (18.2%) (p = 0.016). Conclusions The most common asthma inflammatory cell phenotype in Jilin Province, China is PGA, followed by EA, MGA, and NA. The low prevalence of NA in Jilin Province compared to other countries and also other regions in China might be due to excessive antibiotic use and irregular ICS treatment in this region.https://doi.org/10.1186/s12890-021-01722-0AsthmaInflammatory cell phenotypesInduced sputumUncontrolled asthmaSevere asthma |
| spellingShingle | Bingqing Shi Wei Li Hongna Dong Mengting Xu Yuqiu Hao Peng Gao Distribution of inflammatory phenotypes among patients with asthma in Jilin Province, China: a cross-sectional study BMC Pulmonary Medicine Asthma Inflammatory cell phenotypes Induced sputum Uncontrolled asthma Severe asthma |
| title | Distribution of inflammatory phenotypes among patients with asthma in Jilin Province, China: a cross-sectional study |
| title_full | Distribution of inflammatory phenotypes among patients with asthma in Jilin Province, China: a cross-sectional study |
| title_fullStr | Distribution of inflammatory phenotypes among patients with asthma in Jilin Province, China: a cross-sectional study |
| title_full_unstemmed | Distribution of inflammatory phenotypes among patients with asthma in Jilin Province, China: a cross-sectional study |
| title_short | Distribution of inflammatory phenotypes among patients with asthma in Jilin Province, China: a cross-sectional study |
| title_sort | distribution of inflammatory phenotypes among patients with asthma in jilin province china a cross sectional study |
| topic | Asthma Inflammatory cell phenotypes Induced sputum Uncontrolled asthma Severe asthma |
| url | https://doi.org/10.1186/s12890-021-01722-0 |
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