Atrial fibrillation in cancer survivors – a systematic review and meta-analysis
Abstract Background Atrial fibrillation (AF) is a common cardiac complication during cancer treatment. It is unclear if cancer survivors have increased AF risk when compared to the population. AF screening is now recommended in patients ≥65 years, however there are no specific recommendations in the...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-06-01
|
| Series: | Cardio-Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40959-023-00180-3 |
| _version_ | 1797801278681645056 |
|---|---|
| author | Yueyang Bao John Lee Udit Thakur Satish Ramkumar Thomas H. Marwick |
| author_facet | Yueyang Bao John Lee Udit Thakur Satish Ramkumar Thomas H. Marwick |
| author_sort | Yueyang Bao |
| collection | DOAJ |
| description | Abstract Background Atrial fibrillation (AF) is a common cardiac complication during cancer treatment. It is unclear if cancer survivors have increased AF risk when compared to the population. AF screening is now recommended in patients ≥65 years, however there are no specific recommendations in the oncology population. We sought to compare the AF detection rate of cancer survivors compared to the general population. Methods We searched the Pubmed, Embase and Web of Science databases using search terms related to AF and cancer mapped to subject headings. We included English language studies, limited to adults > 18 years who were > 12 months post completion of cancer treatment. Using a random-effects model we calculated the overall AF detection rate. Meta-regression analysis was performed to assess for potential causes for study heterogeneity. Results Sixteen studies were included in the study. The combined AF detection rate amongst all the studies was 4.7% (95% C.I 4.0-5.4%), which equated to a combined annualised AF rate of 0.7% (95% C.I 0.1–0.98%). There was significant heterogeneity between studies (I 2 = 99.8%, p < 0.001). In the breast cancer cohort (n = 6 studies), the combined annualised AF rate was 0.9% (95% C.I 0.1–2.3%), with significant heterogeneity (I 2 = 99.9%, p < 0.001). Conclusion Whilst the results should be interpreted with caution due to study heterogeneity, AF rates in patients with cancer survival >12 months were not significantly increased compared to the general population. Study Registration Open Science Framework - DOI: https://doi.org/10.17605/OSF.IO/APSYG . |
| first_indexed | 2024-03-13T04:48:02Z |
| format | Article |
| id | doaj.art-f63d1d65ba20402b8cd21020a033d406 |
| institution | Directory Open Access Journal |
| issn | 2057-3804 |
| language | English |
| last_indexed | 2024-03-13T04:48:02Z |
| publishDate | 2023-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardio-Oncology |
| spelling | doaj.art-f63d1d65ba20402b8cd21020a033d4062023-06-18T11:26:09ZengBMCCardio-Oncology2057-38042023-06-019111010.1186/s40959-023-00180-3Atrial fibrillation in cancer survivors – a systematic review and meta-analysisYueyang Bao0John Lee1Udit Thakur2Satish Ramkumar3Thomas H. Marwick4School of Medicine, University of TasmaniaDepartment of Cardiology, Royal Hobart HospitalMonash Cardiovascular Research Centre and MonashHeart, Monash HealthMonash Cardiovascular Research Centre and MonashHeart, Monash HealthBaker Heart and Diabetes InstituteAbstract Background Atrial fibrillation (AF) is a common cardiac complication during cancer treatment. It is unclear if cancer survivors have increased AF risk when compared to the population. AF screening is now recommended in patients ≥65 years, however there are no specific recommendations in the oncology population. We sought to compare the AF detection rate of cancer survivors compared to the general population. Methods We searched the Pubmed, Embase and Web of Science databases using search terms related to AF and cancer mapped to subject headings. We included English language studies, limited to adults > 18 years who were > 12 months post completion of cancer treatment. Using a random-effects model we calculated the overall AF detection rate. Meta-regression analysis was performed to assess for potential causes for study heterogeneity. Results Sixteen studies were included in the study. The combined AF detection rate amongst all the studies was 4.7% (95% C.I 4.0-5.4%), which equated to a combined annualised AF rate of 0.7% (95% C.I 0.1–0.98%). There was significant heterogeneity between studies (I 2 = 99.8%, p < 0.001). In the breast cancer cohort (n = 6 studies), the combined annualised AF rate was 0.9% (95% C.I 0.1–2.3%), with significant heterogeneity (I 2 = 99.9%, p < 0.001). Conclusion Whilst the results should be interpreted with caution due to study heterogeneity, AF rates in patients with cancer survival >12 months were not significantly increased compared to the general population. Study Registration Open Science Framework - DOI: https://doi.org/10.17605/OSF.IO/APSYG .https://doi.org/10.1186/s40959-023-00180-3Atrial fibrillationScreeningSurvivorship |
| spellingShingle | Yueyang Bao John Lee Udit Thakur Satish Ramkumar Thomas H. Marwick Atrial fibrillation in cancer survivors – a systematic review and meta-analysis Cardio-Oncology Atrial fibrillation Screening Survivorship |
| title | Atrial fibrillation in cancer survivors – a systematic review and meta-analysis |
| title_full | Atrial fibrillation in cancer survivors – a systematic review and meta-analysis |
| title_fullStr | Atrial fibrillation in cancer survivors – a systematic review and meta-analysis |
| title_full_unstemmed | Atrial fibrillation in cancer survivors – a systematic review and meta-analysis |
| title_short | Atrial fibrillation in cancer survivors – a systematic review and meta-analysis |
| title_sort | atrial fibrillation in cancer survivors a systematic review and meta analysis |
| topic | Atrial fibrillation Screening Survivorship |
| url | https://doi.org/10.1186/s40959-023-00180-3 |
| work_keys_str_mv | AT yueyangbao atrialfibrillationincancersurvivorsasystematicreviewandmetaanalysis AT johnlee atrialfibrillationincancersurvivorsasystematicreviewandmetaanalysis AT uditthakur atrialfibrillationincancersurvivorsasystematicreviewandmetaanalysis AT satishramkumar atrialfibrillationincancersurvivorsasystematicreviewandmetaanalysis AT thomashmarwick atrialfibrillationincancersurvivorsasystematicreviewandmetaanalysis |