Longitudinal reduction in brain volume in patients with schizophrenia and its association with cognitive function
Abstract Establishing a brain biomarker for schizophrenia is strongly desirable not only to support diagnosis by psychiatrists but also to help track the progressive changes in the brain over the course of the illness. A brain morphological signature of schizophrenia was reported in a recent study a...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2024-03-01
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| Series: | Neuropsychopharmacology Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/npr2.12423 |
| _version_ | 1797263706819657728 |
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| author | Ryuichi Yamazaki Junya Matsumoto Satsuki Ito Kiyotaka Nemoto Masaki Fukunaga Naoki Hashimoto Fumitoshi Kodaka Harumasa Takano Naomi Hasegawa Yuka Yasuda Michiko Fujimoto Hidenaga Yamamori Yoshiyuki Watanabe Kenichiro Miura Ryota Hashimoto |
| author_facet | Ryuichi Yamazaki Junya Matsumoto Satsuki Ito Kiyotaka Nemoto Masaki Fukunaga Naoki Hashimoto Fumitoshi Kodaka Harumasa Takano Naomi Hasegawa Yuka Yasuda Michiko Fujimoto Hidenaga Yamamori Yoshiyuki Watanabe Kenichiro Miura Ryota Hashimoto |
| author_sort | Ryuichi Yamazaki |
| collection | DOAJ |
| description | Abstract Establishing a brain biomarker for schizophrenia is strongly desirable not only to support diagnosis by psychiatrists but also to help track the progressive changes in the brain over the course of the illness. A brain morphological signature of schizophrenia was reported in a recent study and is defined by clusters of brain regions with reduced volume in schizophrenia patients compared to healthy individuals. This signature was proven to be effective at differentiating patients with schizophrenia from healthy individuals, suggesting that it is a good candidate brain biomarker of schizophrenia. However, the longitudinal characteristics of this signature have remained unclear. In this study, we examined whether these changes occurred over time and whether they were associated with clinical outcomes. We found a significant change in the brain morphological signature in schizophrenia patients with more brain volume loss than the natural, age‐related reduction in healthy individuals, suggesting that this change can capture a progressive morphological change in the brain. We further found a significant association between changes in the brain morphological signature and changes in the full‐scale intelligence quotient (IQ). The patients with IQ improvement showed preserved brain morphological signatures, whereas the patients without IQ improvement showed progressive changes in the brain morphological signature, suggesting a link between potential recovery of intellectual abilities and the speed of brain pathology progression. We conclude that the brain morphological signature is a brain biomarker that can be used to evaluate progressive changes in the brain that are associated with cognitive impairment due to schizophrenia. |
| first_indexed | 2024-04-25T00:17:16Z |
| format | Article |
| id | doaj.art-f63d409e9c7f4e6e822e230c480c1440 |
| institution | Directory Open Access Journal |
| issn | 2574-173X |
| language | English |
| last_indexed | 2024-04-25T00:17:16Z |
| publishDate | 2024-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neuropsychopharmacology Reports |
| spelling | doaj.art-f63d409e9c7f4e6e822e230c480c14402024-03-13T03:12:13ZengWileyNeuropsychopharmacology Reports2574-173X2024-03-0144120621510.1002/npr2.12423Longitudinal reduction in brain volume in patients with schizophrenia and its association with cognitive functionRyuichi Yamazaki0Junya Matsumoto1Satsuki Ito2Kiyotaka Nemoto3Masaki Fukunaga4Naoki Hashimoto5Fumitoshi Kodaka6Harumasa Takano7Naomi Hasegawa8Yuka Yasuda9Michiko Fujimoto10Hidenaga Yamamori11Yoshiyuki Watanabe12Kenichiro Miura13Ryota Hashimoto14Department of Pathology of Mental Diseases National Institute of Mental Health, National Center of Neurology and Psychiatry Kodaira JapanDepartment of Pathology of Mental Diseases National Institute of Mental Health, National Center of Neurology and Psychiatry Kodaira JapanDepartment of Pathology of Mental Diseases National Institute of Mental Health, National Center of Neurology and Psychiatry Kodaira JapanDepartment of Psychiatry, Institute of Medicine University of Tsukuba Tsukuba JapanSection of Brain Function Information National Institute for Physiological Sciences Okazaki JapanDepartment of Psychiatry Hokkaido University Graduate School of Medicine Sapporo JapanDepartment of Pathology of Mental Diseases National Institute of Mental Health, National Center of Neurology and Psychiatry Kodaira JapanDepartment of Clinical Neuroimaging, Integrative Brain Imaging Center National Center of Neurology and Psychiatry Kodaira JapanDepartment of Pathology of Mental Diseases National Institute of Mental Health, National Center of Neurology and Psychiatry Kodaira JapanDepartment of Pathology of Mental Diseases National Institute of Mental Health, National Center of Neurology and Psychiatry Kodaira JapanDepartment of Pathology of Mental Diseases National Institute of Mental Health, National Center of Neurology and Psychiatry Kodaira JapanDepartment of Pathology of Mental Diseases National Institute of Mental Health, National Center of Neurology and Psychiatry Kodaira JapanDepartment of Radiology Shiga University of Medical Science Otsu JapanDepartment of Pathology of Mental Diseases National Institute of Mental Health, National Center of Neurology and Psychiatry Kodaira JapanDepartment of Pathology of Mental Diseases National Institute of Mental Health, National Center of Neurology and Psychiatry Kodaira JapanAbstract Establishing a brain biomarker for schizophrenia is strongly desirable not only to support diagnosis by psychiatrists but also to help track the progressive changes in the brain over the course of the illness. A brain morphological signature of schizophrenia was reported in a recent study and is defined by clusters of brain regions with reduced volume in schizophrenia patients compared to healthy individuals. This signature was proven to be effective at differentiating patients with schizophrenia from healthy individuals, suggesting that it is a good candidate brain biomarker of schizophrenia. However, the longitudinal characteristics of this signature have remained unclear. In this study, we examined whether these changes occurred over time and whether they were associated with clinical outcomes. We found a significant change in the brain morphological signature in schizophrenia patients with more brain volume loss than the natural, age‐related reduction in healthy individuals, suggesting that this change can capture a progressive morphological change in the brain. We further found a significant association between changes in the brain morphological signature and changes in the full‐scale intelligence quotient (IQ). The patients with IQ improvement showed preserved brain morphological signatures, whereas the patients without IQ improvement showed progressive changes in the brain morphological signature, suggesting a link between potential recovery of intellectual abilities and the speed of brain pathology progression. We conclude that the brain morphological signature is a brain biomarker that can be used to evaluate progressive changes in the brain that are associated with cognitive impairment due to schizophrenia.https://doi.org/10.1002/npr2.12423biomarkercognitive declinelongitudinal studyschizophreniastructural MRI |
| spellingShingle | Ryuichi Yamazaki Junya Matsumoto Satsuki Ito Kiyotaka Nemoto Masaki Fukunaga Naoki Hashimoto Fumitoshi Kodaka Harumasa Takano Naomi Hasegawa Yuka Yasuda Michiko Fujimoto Hidenaga Yamamori Yoshiyuki Watanabe Kenichiro Miura Ryota Hashimoto Longitudinal reduction in brain volume in patients with schizophrenia and its association with cognitive function Neuropsychopharmacology Reports biomarker cognitive decline longitudinal study schizophrenia structural MRI |
| title | Longitudinal reduction in brain volume in patients with schizophrenia and its association with cognitive function |
| title_full | Longitudinal reduction in brain volume in patients with schizophrenia and its association with cognitive function |
| title_fullStr | Longitudinal reduction in brain volume in patients with schizophrenia and its association with cognitive function |
| title_full_unstemmed | Longitudinal reduction in brain volume in patients with schizophrenia and its association with cognitive function |
| title_short | Longitudinal reduction in brain volume in patients with schizophrenia and its association with cognitive function |
| title_sort | longitudinal reduction in brain volume in patients with schizophrenia and its association with cognitive function |
| topic | biomarker cognitive decline longitudinal study schizophrenia structural MRI |
| url | https://doi.org/10.1002/npr2.12423 |
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