Exploring the association among the tryptophan to serotonin and kynurenine pathways, cognition and suicidal behaviour: a secondary analysis in a sample of individuals affected by Bipolar Disorder.
Introduction Stroop test iteration performances and metabolism of tryptophan (TRP) via serotonin (5-HT) and kynurenine (KYN) have both been associated with suicidal behaviors. This study aims to probe their possible interactions. Objectives We explored the association of the performances on the Emo...
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Cambridge University Press
2023-03-01
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| Series: | European Psychiatry |
| Online Access: | https://www.cambridge.org/core/product/identifier/S0924933823002651/type/journal_article |
| _version_ | 1827753664296517632 |
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| author | P. Paribello M. Manchia A. Squassina C. Pisanu D. Congiu S. Dall’Acqua S. Sut S. Nasini M. Garzilli B. Guiso F. Suprani V. Pulcinelli M. N. Iaselli I. Pinna G. Somaini L. Arru C. Corrias F. Pinna S. Comai B. Carpiniello |
| author_facet | P. Paribello M. Manchia A. Squassina C. Pisanu D. Congiu S. Dall’Acqua S. Sut S. Nasini M. Garzilli B. Guiso F. Suprani V. Pulcinelli M. N. Iaselli I. Pinna G. Somaini L. Arru C. Corrias F. Pinna S. Comai B. Carpiniello |
| author_sort | P. Paribello |
| collection | DOAJ |
| description |
Introduction
Stroop test iteration performances and metabolism of tryptophan (TRP) via serotonin (5-HT) and kynurenine (KYN) have both been associated with suicidal behaviors. This study aims to probe their possible interactions.
Objectives
We explored the association of the performances on the Emotion Inhibition Subtask (EIS) of the Brief Assessment of Cognition for Affective Disorder and the plasmatic levels of 5-hydroxytryptophan (5-HTP), 5-HT, KYN, melatonin (MLT) among subjects with Lifetime Suicidal Ideation (LSI) vs non-LSI, and with Lifetime Suicide Attempts (LSA) vs non-LSA.
Methods
Using R studio, we employed: 1) the t-test for parametric data and the Wilcoxon test for non-parametric data; 2) Linear Modeling to probe the associations of EIS performances with MLT, KYN, 5-HTP or 5-HT plasmatic levels.
Results
In a sample comprising 45 individuals affected by Bipolar Disorder, we found a statistically significant difference for the Color Naming (CN, image 1) and the Neutral words (NW) subtasks among LSA vs non-LSA. In LSI vs non-LSI, only the NW retained significance, but not the CN. A significant association emerged between CN and 5-HTP in LSI but not in non-LSI (image 2). Similarly, in LSA, an association was found between CN and 5-HTP, but not in non-LSA (image 3). No statistically significant difference emerged among groups regarding gender composition, age, pharmacological therapy, Body Mass Index, Hamilton Depression Rating Scale, Young Mania Rating Scale, or Clinical Global Impression scale - Severity.
Image:
Image 2:
Image 3:
Conclusions
We found that the plasmatic levels of the metabolites of TRP via 5-HT were correlated to some EIS performances. These findings may represent a hypothesis-generating platform for further investigations.
Disclosure of InterestNone Declared |
| first_indexed | 2024-03-11T07:38:39Z |
| format | Article |
| id | doaj.art-f63d616390fb453bb8fa17e9acab938a |
| institution | Directory Open Access Journal |
| issn | 0924-9338 1778-3585 |
| language | English |
| last_indexed | 2024-03-11T07:38:39Z |
| publishDate | 2023-03-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | European Psychiatry |
| spelling | doaj.art-f63d616390fb453bb8fa17e9acab938a2023-11-17T05:09:07ZengCambridge University PressEuropean Psychiatry0924-93381778-35852023-03-0166S86S8710.1192/j.eurpsy.2023.265Exploring the association among the tryptophan to serotonin and kynurenine pathways, cognition and suicidal behaviour: a secondary analysis in a sample of individuals affected by Bipolar Disorder.P. Paribello0M. Manchia1A. Squassina2C. Pisanu3D. Congiu4S. Dall’Acqua5S. Sut6S. Nasini7M. Garzilli8B. Guiso9F. Suprani10V. Pulcinelli11M. N. Iaselli12I. Pinna13G. Somaini14L. Arru15C. Corrias16F. Pinna17S. Comai18B. Carpiniello19Department of Medical Sciences and Public Health, Unit of Clinical Psychiatry, University Hospital Agency of Cagliari, Cagliari, ItalyDepartment of Medical Sciences and Public Health, Unit of Clinical Psychiatry, University Hospital Agency of Cagliari, Cagliari, Italy Department of Pharmacology, Dalhousie University, Halifax, CanadaDepartment of Biomedical Science, Section of Neuroscience and Clinical Pharmacology, University of Cagliari, CagliariDepartment of Biomedical Science, Section of Neuroscience and Clinical Pharmacology, University of Cagliari, CagliariDepartment of Biomedical Science, Section of Neuroscience and Clinical Pharmacology, University of Cagliari, CagliariDepartment of Pharmaceutical and Pharmacological SciencesDepartment of Pharmaceutical and Pharmacological SciencesDepartment of Pharmaceutical and Pharmacological SciencesDepartment of Medical Sciences and Public Health, Unit of Clinical Psychiatry, University Hospital Agency of Cagliari, Cagliari, ItalyDepartment of Medical Sciences and Public Health, Unit of Clinical Psychiatry, University Hospital Agency of Cagliari, Cagliari, ItalyDepartment of Medical Sciences and Public Health, Unit of Clinical Psychiatry, University Hospital Agency of Cagliari, Cagliari, ItalyDepartment of Medical Sciences and Public Health, Unit of Clinical Psychiatry, University Hospital Agency of Cagliari, Cagliari, ItalyDepartment of Medical Sciences and Public Health, Unit of Clinical Psychiatry, University Hospital Agency of Cagliari, Cagliari, ItalyDepartment of Medical Sciences and Public Health, Unit of Clinical Psychiatry, University Hospital Agency of Cagliari, Cagliari, ItalyDepartment of Medical Sciences and Public Health, Unit of Clinical Psychiatry, University Hospital Agency of Cagliari, Cagliari, ItalyDepartment of Medical Sciences and Public Health, Unit of Clinical Psychiatry, University Hospital Agency of Cagliari, Cagliari, ItalyDepartment of Medical Sciences and Public Health, Unit of Clinical Psychiatry, University Hospital Agency of Cagliari, Cagliari, ItalyDepartment of Medical Sciences and Public Health, Unit of Clinical Psychiatry, University Hospital Agency of Cagliari, Cagliari, ItalyDepartment of Biomedical Sciences, University of Padova, Padova San Raffaele Scientific Institute, Milan, Italy Department of Psychiatry, McGill University, Montreal, CanadaDepartment of Medical Sciences and Public Health, Unit of Clinical Psychiatry, University Hospital Agency of Cagliari, Cagliari, Italy Introduction Stroop test iteration performances and metabolism of tryptophan (TRP) via serotonin (5-HT) and kynurenine (KYN) have both been associated with suicidal behaviors. This study aims to probe their possible interactions. Objectives We explored the association of the performances on the Emotion Inhibition Subtask (EIS) of the Brief Assessment of Cognition for Affective Disorder and the plasmatic levels of 5-hydroxytryptophan (5-HTP), 5-HT, KYN, melatonin (MLT) among subjects with Lifetime Suicidal Ideation (LSI) vs non-LSI, and with Lifetime Suicide Attempts (LSA) vs non-LSA. Methods Using R studio, we employed: 1) the t-test for parametric data and the Wilcoxon test for non-parametric data; 2) Linear Modeling to probe the associations of EIS performances with MLT, KYN, 5-HTP or 5-HT plasmatic levels. Results In a sample comprising 45 individuals affected by Bipolar Disorder, we found a statistically significant difference for the Color Naming (CN, image 1) and the Neutral words (NW) subtasks among LSA vs non-LSA. In LSI vs non-LSI, only the NW retained significance, but not the CN. A significant association emerged between CN and 5-HTP in LSI but not in non-LSI (image 2). Similarly, in LSA, an association was found between CN and 5-HTP, but not in non-LSA (image 3). No statistically significant difference emerged among groups regarding gender composition, age, pharmacological therapy, Body Mass Index, Hamilton Depression Rating Scale, Young Mania Rating Scale, or Clinical Global Impression scale - Severity. Image: Image 2: Image 3: Conclusions We found that the plasmatic levels of the metabolites of TRP via 5-HT were correlated to some EIS performances. These findings may represent a hypothesis-generating platform for further investigations. Disclosure of InterestNone Declaredhttps://www.cambridge.org/core/product/identifier/S0924933823002651/type/journal_article |
| spellingShingle | P. Paribello M. Manchia A. Squassina C. Pisanu D. Congiu S. Dall’Acqua S. Sut S. Nasini M. Garzilli B. Guiso F. Suprani V. Pulcinelli M. N. Iaselli I. Pinna G. Somaini L. Arru C. Corrias F. Pinna S. Comai B. Carpiniello Exploring the association among the tryptophan to serotonin and kynurenine pathways, cognition and suicidal behaviour: a secondary analysis in a sample of individuals affected by Bipolar Disorder. European Psychiatry |
| title | Exploring the association among the tryptophan to serotonin and kynurenine pathways, cognition and suicidal behaviour: a secondary analysis in a sample of individuals affected by Bipolar Disorder. |
| title_full | Exploring the association among the tryptophan to serotonin and kynurenine pathways, cognition and suicidal behaviour: a secondary analysis in a sample of individuals affected by Bipolar Disorder. |
| title_fullStr | Exploring the association among the tryptophan to serotonin and kynurenine pathways, cognition and suicidal behaviour: a secondary analysis in a sample of individuals affected by Bipolar Disorder. |
| title_full_unstemmed | Exploring the association among the tryptophan to serotonin and kynurenine pathways, cognition and suicidal behaviour: a secondary analysis in a sample of individuals affected by Bipolar Disorder. |
| title_short | Exploring the association among the tryptophan to serotonin and kynurenine pathways, cognition and suicidal behaviour: a secondary analysis in a sample of individuals affected by Bipolar Disorder. |
| title_sort | exploring the association among the tryptophan to serotonin and kynurenine pathways cognition and suicidal behaviour a secondary analysis in a sample of individuals affected by bipolar disorder |
| url | https://www.cambridge.org/core/product/identifier/S0924933823002651/type/journal_article |
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