Stromal ETS2 Regulates Chemokine Production and Immune Cell Recruitment during Acinar-to-Ductal Metaplasia

Stromal ETS2 Regulates Chemokine Production and Immune Cell Recruitment during Acinar-to-Ductal Metaplasia

Preclinical studies have suggested that the pancreatic tumor microenvironment both inhibits and promotes tumor development and growth. Here we establish the role of stromal fibroblasts during acinar-to-ductal metaplasia (ADM), an initiating event in pancreatic cancer formation. The transcription fac...

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Bibliographic Details
Main Authors: Jason R. Pitarresi, Xin Liu, Sudarshana M. Sharma, Maria C. Cuitiño, Raleigh D. Kladney, Thomas A. Mace, Sydney Donohue, Sunayana G. Nayak, Chunjing Qu, James Lee, Sarah A. Woelke, Stefan Trela, Kyle LaPak, Lianbo Yu, Joseph McElroy, Thomas J. Rosol, Reena Shakya, Thomas Ludwig, Gregory B. Lesinski, Soledad A. Fernandez, Stephen F. Konieczny, Gustavo Leone, Jinghai Wu, Michael C. Ostrowski
Format: Article
Language:English
Published: Elsevier 2016-09-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558616300367

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