A review on association of fungi with the development and progression of carcinogenesis in the human body
The role and impact of commensal and pathogenic fungi in different parts of the human body are being increasingly appreciated, unveiling the importance of such microorganisms in human health. A key function is the involvement of the mycobiota in cross-kingdom interactions within the microbiome. Any...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Current Research in Microbial Sciences |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666517421000705 |
| _version_ | 1811202202238189568 |
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| author | Marie Andrea Laetitia Huët Chuen Zhang Lee Sadequr Rahman |
| author_facet | Marie Andrea Laetitia Huët Chuen Zhang Lee Sadequr Rahman |
| author_sort | Marie Andrea Laetitia Huët |
| collection | DOAJ |
| description | The role and impact of commensal and pathogenic fungi in different parts of the human body are being increasingly appreciated, unveiling the importance of such microorganisms in human health. A key function is the involvement of the mycobiota in cross-kingdom interactions within the microbiome. Any disturbance in the functionality of the microbiota could alter metabolic reactions, have a negative impact on homeostasis or induce diseases. The association of fungi with cancer development is the focus of this review. Several studies have reported direct or indirect involvement of fungal pathogens and mycobiome dysbiosis in induction of carcinogenesis. Most studies focused on cancers of the gastrointestinal tract. However, researchers are now investigating other organs, such as the skin, where the significant results obtained confirm the involvement of fungal pathogens and administration of antifungal drugs in development of cancer. This review gives an overview of the different organs affected and describes the mechanisms used by these eukaryotes or antifungals to induce oncogenesis. |
| first_indexed | 2024-04-12T02:34:54Z |
| format | Article |
| id | doaj.art-f644899e0137466eb3d055341c523c2d |
| institution | Directory Open Access Journal |
| issn | 2666-5174 |
| language | English |
| last_indexed | 2024-04-12T02:34:54Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Research in Microbial Sciences |
| spelling | doaj.art-f644899e0137466eb3d055341c523c2d2022-12-22T03:51:36ZengElsevierCurrent Research in Microbial Sciences2666-51742022-01-013100090A review on association of fungi with the development and progression of carcinogenesis in the human bodyMarie Andrea Laetitia Huët0Chuen Zhang Lee1Sadequr Rahman2School of Science, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway,Subang Jaya, Selangor 47500, MalaysiaSchool of Science, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway,Subang Jaya, Selangor 47500, MalaysiaSchool of Science, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway,Subang Jaya, Selangor 47500, Malaysia; Tropical Medicine and Biology Multidisciplinary Platform, Monash University Malaysia, Subang Jaya, Malaysia; Corresponding author ar: School of Science, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway,Subang Jaya, Selangor 47500, Malaysia.The role and impact of commensal and pathogenic fungi in different parts of the human body are being increasingly appreciated, unveiling the importance of such microorganisms in human health. A key function is the involvement of the mycobiota in cross-kingdom interactions within the microbiome. Any disturbance in the functionality of the microbiota could alter metabolic reactions, have a negative impact on homeostasis or induce diseases. The association of fungi with cancer development is the focus of this review. Several studies have reported direct or indirect involvement of fungal pathogens and mycobiome dysbiosis in induction of carcinogenesis. Most studies focused on cancers of the gastrointestinal tract. However, researchers are now investigating other organs, such as the skin, where the significant results obtained confirm the involvement of fungal pathogens and administration of antifungal drugs in development of cancer. This review gives an overview of the different organs affected and describes the mechanisms used by these eukaryotes or antifungals to induce oncogenesis.http://www.sciencedirect.com/science/article/pii/S2666517421000705CancerFungal dysbiosisFungal pathogenMetastasisHuman mycobiota |
| spellingShingle | Marie Andrea Laetitia Huët Chuen Zhang Lee Sadequr Rahman A review on association of fungi with the development and progression of carcinogenesis in the human body Current Research in Microbial Sciences Cancer Fungal dysbiosis Fungal pathogen Metastasis Human mycobiota |
| title | A review on association of fungi with the development and progression of carcinogenesis in the human body |
| title_full | A review on association of fungi with the development and progression of carcinogenesis in the human body |
| title_fullStr | A review on association of fungi with the development and progression of carcinogenesis in the human body |
| title_full_unstemmed | A review on association of fungi with the development and progression of carcinogenesis in the human body |
| title_short | A review on association of fungi with the development and progression of carcinogenesis in the human body |
| title_sort | review on association of fungi with the development and progression of carcinogenesis in the human body |
| topic | Cancer Fungal dysbiosis Fungal pathogen Metastasis Human mycobiota |
| url | http://www.sciencedirect.com/science/article/pii/S2666517421000705 |
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