Overlapping Syndromes: Drug-Induced Vasculitis From Hydralazine With Positive Antinuclear Antibodies
Hydralazine is an antihypertensive medication that has been associated with drug-associated autoimmune syndromes like interstitial lung disease, pauci-immune glomerulonephritis, and hypocomplementemia. Hydralazine-induced ANCA-associated vasculitis and hydralazine induced positive antinuclear antibo...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2023-01-01
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| Series: | Clinical Medicine Insights: Case Reports |
| Online Access: | https://doi.org/10.1177/11795476221146906 |
| _version_ | 1797955804389703680 |
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| author | Lakshmi Kannan UmmeRubab Syeda |
| author_facet | Lakshmi Kannan UmmeRubab Syeda |
| author_sort | Lakshmi Kannan |
| collection | DOAJ |
| description | Hydralazine is an antihypertensive medication that has been associated with drug-associated autoimmune syndromes like interstitial lung disease, pauci-immune glomerulonephritis, and hypocomplementemia. Hydralazine-induced ANCA-associated vasculitis and hydralazine induced positive antinuclear antibodies are rare. Clinical manifestations range from arthralgia, petechiae, or rash to multiorgan involvement. When presented as pulmonary-renal syndrome, it can be rapidly progressive and fatal. Here, we describe a case of hydralazine-associated vasculitis with rapidly progressive glomerulonephritis and highlight the importance of early diagnosis and prompt treatment. |
| first_indexed | 2024-04-10T23:38:51Z |
| format | Article |
| id | doaj.art-f645d508345845eeba11ee4c9d48b665 |
| institution | Directory Open Access Journal |
| issn | 1179-5476 |
| language | English |
| last_indexed | 2024-04-10T23:38:51Z |
| publishDate | 2023-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Clinical Medicine Insights: Case Reports |
| spelling | doaj.art-f645d508345845eeba11ee4c9d48b6652023-01-11T14:03:32ZengSAGE PublishingClinical Medicine Insights: Case Reports1179-54762023-01-011610.1177/11795476221146906Overlapping Syndromes: Drug-Induced Vasculitis From Hydralazine With Positive Antinuclear AntibodiesLakshmi KannanUmmeRubab SyedaHydralazine is an antihypertensive medication that has been associated with drug-associated autoimmune syndromes like interstitial lung disease, pauci-immune glomerulonephritis, and hypocomplementemia. Hydralazine-induced ANCA-associated vasculitis and hydralazine induced positive antinuclear antibodies are rare. Clinical manifestations range from arthralgia, petechiae, or rash to multiorgan involvement. When presented as pulmonary-renal syndrome, it can be rapidly progressive and fatal. Here, we describe a case of hydralazine-associated vasculitis with rapidly progressive glomerulonephritis and highlight the importance of early diagnosis and prompt treatment.https://doi.org/10.1177/11795476221146906 |
| spellingShingle | Lakshmi Kannan UmmeRubab Syeda Overlapping Syndromes: Drug-Induced Vasculitis From Hydralazine With Positive Antinuclear Antibodies Clinical Medicine Insights: Case Reports |
| title | Overlapping Syndromes: Drug-Induced Vasculitis From Hydralazine With Positive Antinuclear Antibodies |
| title_full | Overlapping Syndromes: Drug-Induced Vasculitis From Hydralazine With Positive Antinuclear Antibodies |
| title_fullStr | Overlapping Syndromes: Drug-Induced Vasculitis From Hydralazine With Positive Antinuclear Antibodies |
| title_full_unstemmed | Overlapping Syndromes: Drug-Induced Vasculitis From Hydralazine With Positive Antinuclear Antibodies |
| title_short | Overlapping Syndromes: Drug-Induced Vasculitis From Hydralazine With Positive Antinuclear Antibodies |
| title_sort | overlapping syndromes drug induced vasculitis from hydralazine with positive antinuclear antibodies |
| url | https://doi.org/10.1177/11795476221146906 |
| work_keys_str_mv | AT lakshmikannan overlappingsyndromesdruginducedvasculitisfromhydralazinewithpositiveantinuclearantibodies AT ummerubabsyeda overlappingsyndromesdruginducedvasculitisfromhydralazinewithpositiveantinuclearantibodies |