Abnormal dynamic functional connectivity between speech and auditory areas in schizophrenia patients with auditory hallucinations
Purpose: Auditory hallucinations (AH), typically hearing voices, are a core symptom in schizophrenia. They may result from deficits in dynamic functional connectivity (FC) between cortical regions supporting speech production and language perception that interfere with the ability to recognize self-...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2018-01-01
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| Series: | NeuroImage: Clinical |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158218302018 |
| _version_ | 1818038828739330048 |
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| author | Wenjing Zhang Siyi Li Xiuli Wang Yao Gong Li Yao Yuan Xiao Jieke Liu Sarah K. Keedy Qiyong Gong John A. Sweeney Su Lui |
| author_facet | Wenjing Zhang Siyi Li Xiuli Wang Yao Gong Li Yao Yuan Xiao Jieke Liu Sarah K. Keedy Qiyong Gong John A. Sweeney Su Lui |
| author_sort | Wenjing Zhang |
| collection | DOAJ |
| description | Purpose: Auditory hallucinations (AH), typically hearing voices, are a core symptom in schizophrenia. They may result from deficits in dynamic functional connectivity (FC) between cortical regions supporting speech production and language perception that interfere with the ability to recognize self-generated speech as not coming from external sources. We tested this hypothesis by investigating dynamic connectivity between the frontal cortex region related to language production and the temporal cortex region related to auditory processing. Methods: Resting-state fMRI scans were acquired from 18 schizophrenia patients with AH (AH+), 17 schizophrenia patients without AH (AH-) and 22 healthy controls. A multiband sequence with TR = 427 ms was adopted to provide relatively high temporal resolution data for characterizing dynamic FC. Analysis focused on connectivity between speech production and language comprehension areas, eloquent language cortex in the left hemisphere. Two frequency bands of brain oscillatory activity were evaluated (0.01–0.027 Hz, 0.027–0.08 Hz) in which differential alterations that have been previously linked to schizophrenia. Conventional static FC maps of these seeds were also calculated. Results: Dynamic connectivity analysis indicated that AH+ patients showed not only less temporal variability but transient lower strength in connectivity between speech and auditory areas than healthy controls, while AH- patients not. These findings were restricted to 0.027–0.08 Hz activity. In static connectivity analysis, no significant differences were observed in connectivity between speech production and language comprehension areas in either frequency band. Conclusions: Reduced temporal variability and connectivity strength between key regions of eloquent language cortex may represent a mechanism for AH in schizophrenia. Keywords: Schizophrenia, Auditory hallucinations, Dynamic, Functional connectivity, Language areas, Multiband |
| first_indexed | 2024-12-10T07:48:57Z |
| format | Article |
| id | doaj.art-f6466d68d731489e9eb1ff51693c2328 |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-12-10T07:48:57Z |
| publishDate | 2018-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-f6466d68d731489e9eb1ff51693c23282022-12-22T01:57:07ZengElsevierNeuroImage: Clinical2213-15822018-01-0119918924Abnormal dynamic functional connectivity between speech and auditory areas in schizophrenia patients with auditory hallucinationsWenjing Zhang0Siyi Li1Xiuli Wang2Yao Gong3Li Yao4Yuan Xiao5Jieke Liu6Sarah K. Keedy7Qiyong Gong8John A. Sweeney9Su Lui10Department of Radiology, The Center for Medical Imaging, West China Hospital of Sichuan University, Chengdu, China; Huaxi MR Research Center (HMRRC), West China Hospital of Sichuan University, Chengdu, ChinaDepartment of Radiology, The Center for Medical Imaging, West China Hospital of Sichuan University, Chengdu, China; Huaxi MR Research Center (HMRRC), West China Hospital of Sichuan University, Chengdu, ChinaThe Fourth People’s Hospital of Chengdu, Chengdu, ChinaThe Fourth People’s Hospital of Chengdu, Chengdu, ChinaDepartment of Radiology, The Center for Medical Imaging, West China Hospital of Sichuan University, Chengdu, China; Huaxi MR Research Center (HMRRC), West China Hospital of Sichuan University, Chengdu, ChinaDepartment of Radiology, The Center for Medical Imaging, West China Hospital of Sichuan University, Chengdu, China; Huaxi MR Research Center (HMRRC), West China Hospital of Sichuan University, Chengdu, ChinaDepartment of Radiology, The Center for Medical Imaging, West China Hospital of Sichuan University, Chengdu, China; Huaxi MR Research Center (HMRRC), West China Hospital of Sichuan University, Chengdu, ChinaDepartment of Psychiatry and Behavioral Neuroscience, University of Chicago, IL, USAHuaxi MR Research Center (HMRRC), West China Hospital of Sichuan University, Chengdu, ChinaHuaxi MR Research Center (HMRRC), West China Hospital of Sichuan University, Chengdu, China; Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, OH, USADepartment of Radiology, The Center for Medical Imaging, West China Hospital of Sichuan University, Chengdu, China; Huaxi MR Research Center (HMRRC), West China Hospital of Sichuan University, Chengdu, China; Department of Radiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China; Corresponding author at: Department of Radiology, The Center for Medical Imaging, West China Hospital of Sichuan University, No. 37 Guoxue Alley, Chengdu 610041, China.Purpose: Auditory hallucinations (AH), typically hearing voices, are a core symptom in schizophrenia. They may result from deficits in dynamic functional connectivity (FC) between cortical regions supporting speech production and language perception that interfere with the ability to recognize self-generated speech as not coming from external sources. We tested this hypothesis by investigating dynamic connectivity between the frontal cortex region related to language production and the temporal cortex region related to auditory processing. Methods: Resting-state fMRI scans were acquired from 18 schizophrenia patients with AH (AH+), 17 schizophrenia patients without AH (AH-) and 22 healthy controls. A multiband sequence with TR = 427 ms was adopted to provide relatively high temporal resolution data for characterizing dynamic FC. Analysis focused on connectivity between speech production and language comprehension areas, eloquent language cortex in the left hemisphere. Two frequency bands of brain oscillatory activity were evaluated (0.01–0.027 Hz, 0.027–0.08 Hz) in which differential alterations that have been previously linked to schizophrenia. Conventional static FC maps of these seeds were also calculated. Results: Dynamic connectivity analysis indicated that AH+ patients showed not only less temporal variability but transient lower strength in connectivity between speech and auditory areas than healthy controls, while AH- patients not. These findings were restricted to 0.027–0.08 Hz activity. In static connectivity analysis, no significant differences were observed in connectivity between speech production and language comprehension areas in either frequency band. Conclusions: Reduced temporal variability and connectivity strength between key regions of eloquent language cortex may represent a mechanism for AH in schizophrenia. Keywords: Schizophrenia, Auditory hallucinations, Dynamic, Functional connectivity, Language areas, Multibandhttp://www.sciencedirect.com/science/article/pii/S2213158218302018 |
| spellingShingle | Wenjing Zhang Siyi Li Xiuli Wang Yao Gong Li Yao Yuan Xiao Jieke Liu Sarah K. Keedy Qiyong Gong John A. Sweeney Su Lui Abnormal dynamic functional connectivity between speech and auditory areas in schizophrenia patients with auditory hallucinations NeuroImage: Clinical |
| title | Abnormal dynamic functional connectivity between speech and auditory areas in schizophrenia patients with auditory hallucinations |
| title_full | Abnormal dynamic functional connectivity between speech and auditory areas in schizophrenia patients with auditory hallucinations |
| title_fullStr | Abnormal dynamic functional connectivity between speech and auditory areas in schizophrenia patients with auditory hallucinations |
| title_full_unstemmed | Abnormal dynamic functional connectivity between speech and auditory areas in schizophrenia patients with auditory hallucinations |
| title_short | Abnormal dynamic functional connectivity between speech and auditory areas in schizophrenia patients with auditory hallucinations |
| title_sort | abnormal dynamic functional connectivity between speech and auditory areas in schizophrenia patients with auditory hallucinations |
| url | http://www.sciencedirect.com/science/article/pii/S2213158218302018 |
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