An agent-based model of monocyte differentiation into tumour-associated macrophages in chronic lymphocytic leukemia
Summary: Monocyte-derived macrophages help maintain tissue homeostasis and defend the organism against pathogens. In tumors, recent studies have uncovered complex macrophage populations, including tumor-associated macrophages, which support tumorigenesis through cancer hallmarks such as immunosuppre...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004223009744 |
| _version_ | 1827933010711805952 |
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| author | Nina Verstraete Malvina Marku Marcin Domagala Hélène Arduin Julie Bordenave Jean-Jacques Fournié Loïc Ysebaert Mary Poupot Vera Pancaldi |
| author_facet | Nina Verstraete Malvina Marku Marcin Domagala Hélène Arduin Julie Bordenave Jean-Jacques Fournié Loïc Ysebaert Mary Poupot Vera Pancaldi |
| author_sort | Nina Verstraete |
| collection | DOAJ |
| description | Summary: Monocyte-derived macrophages help maintain tissue homeostasis and defend the organism against pathogens. In tumors, recent studies have uncovered complex macrophage populations, including tumor-associated macrophages, which support tumorigenesis through cancer hallmarks such as immunosuppression, angiogenesis, or matrix remodeling. In the case of chronic lymphocytic leukemia, these macrophages are known as nurse-like cells (NLCs) and they protect leukemic cells from spontaneous apoptosis, contributing to their chemoresistance. We propose an agent-based model of monocyte differentiation into NLCs upon contact with leukemic B cells in vitro. We performed patient-specific model optimization using cultures of peripheral blood mononuclear cells from patients. Using our model, we were able to reproduce the temporal survival dynamics of cancer cells in a patient-specific manner and to identify patient groups related to distinct macrophage phenotypes. Our results show a potentially important role of phagocytosis in the polarization process of NLCs and in promoting cancer cells’ enhanced survival. |
| first_indexed | 2024-03-13T07:17:38Z |
| format | Article |
| id | doaj.art-f648bf1b897f435598db29d0f5608254 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-03-13T07:17:38Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-f648bf1b897f435598db29d0f56082542023-06-05T04:13:03ZengElsevieriScience2589-00422023-06-01266106897An agent-based model of monocyte differentiation into tumour-associated macrophages in chronic lymphocytic leukemiaNina Verstraete0Malvina Marku1Marcin Domagala2Hélène Arduin3Julie Bordenave4Jean-Jacques Fournié5Loïc Ysebaert6Mary Poupot7Vera Pancaldi8CRCT, Université de Toulouse, Inserm, CNRS, Université Toulouse III-Paul Sabatier, Centre de Recherches en Cancérologie de Toulouse, Toulouse, FranceCRCT, Université de Toulouse, Inserm, CNRS, Université Toulouse III-Paul Sabatier, Centre de Recherches en Cancérologie de Toulouse, Toulouse, FranceCRCT, Université de Toulouse, Inserm, CNRS, Université Toulouse III-Paul Sabatier, Centre de Recherches en Cancérologie de Toulouse, Toulouse, FranceCRCT, Université de Toulouse, Inserm, CNRS, Université Toulouse III-Paul Sabatier, Centre de Recherches en Cancérologie de Toulouse, Toulouse, FranceCRCT, Université de Toulouse, Inserm, CNRS, Université Toulouse III-Paul Sabatier, Centre de Recherches en Cancérologie de Toulouse, Toulouse, FranceCRCT, Université de Toulouse, Inserm, CNRS, Université Toulouse III-Paul Sabatier, Centre de Recherches en Cancérologie de Toulouse, Toulouse, FranceService d’Hématologie, Institut Universitaire du Cancer de Toulouse-Oncopole, 31330 Toulouse, FranceCRCT, Université de Toulouse, Inserm, CNRS, Université Toulouse III-Paul Sabatier, Centre de Recherches en Cancérologie de Toulouse, Toulouse, FranceCRCT, Université de Toulouse, Inserm, CNRS, Université Toulouse III-Paul Sabatier, Centre de Recherches en Cancérologie de Toulouse, Toulouse, France; Barcelona Supercomputing Center, Carrer de Jordi Girona, 29, 31, 08034 Barcelona, Spain; Corresponding authorSummary: Monocyte-derived macrophages help maintain tissue homeostasis and defend the organism against pathogens. In tumors, recent studies have uncovered complex macrophage populations, including tumor-associated macrophages, which support tumorigenesis through cancer hallmarks such as immunosuppression, angiogenesis, or matrix remodeling. In the case of chronic lymphocytic leukemia, these macrophages are known as nurse-like cells (NLCs) and they protect leukemic cells from spontaneous apoptosis, contributing to their chemoresistance. We propose an agent-based model of monocyte differentiation into NLCs upon contact with leukemic B cells in vitro. We performed patient-specific model optimization using cultures of peripheral blood mononuclear cells from patients. Using our model, we were able to reproduce the temporal survival dynamics of cancer cells in a patient-specific manner and to identify patient groups related to distinct macrophage phenotypes. Our results show a potentially important role of phagocytosis in the polarization process of NLCs and in promoting cancer cells’ enhanced survival.http://www.sciencedirect.com/science/article/pii/S2589004223009744Health sciencesImmunologyComputational bioinformaticsCancer |
| spellingShingle | Nina Verstraete Malvina Marku Marcin Domagala Hélène Arduin Julie Bordenave Jean-Jacques Fournié Loïc Ysebaert Mary Poupot Vera Pancaldi An agent-based model of monocyte differentiation into tumour-associated macrophages in chronic lymphocytic leukemia iScience Health sciences Immunology Computational bioinformatics Cancer |
| title | An agent-based model of monocyte differentiation into tumour-associated macrophages in chronic lymphocytic leukemia |
| title_full | An agent-based model of monocyte differentiation into tumour-associated macrophages in chronic lymphocytic leukemia |
| title_fullStr | An agent-based model of monocyte differentiation into tumour-associated macrophages in chronic lymphocytic leukemia |
| title_full_unstemmed | An agent-based model of monocyte differentiation into tumour-associated macrophages in chronic lymphocytic leukemia |
| title_short | An agent-based model of monocyte differentiation into tumour-associated macrophages in chronic lymphocytic leukemia |
| title_sort | agent based model of monocyte differentiation into tumour associated macrophages in chronic lymphocytic leukemia |
| topic | Health sciences Immunology Computational bioinformatics Cancer |
| url | http://www.sciencedirect.com/science/article/pii/S2589004223009744 |
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