The Usefulness of Mesenchymal Stem Cells beyond the Musculoskeletal System in Horses
The differentiation ability of mesenchymal stem cells (MSCs) initially raised interest for treating musculoskeletal injuries in horses, but MSC paracrine activity has widened their scope for inflammatory and immune-mediated pathologies in both equine and human medicine. Furthermore, the similar etio...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | Animals |
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| Online Access: | https://www.mdpi.com/2076-2615/11/4/931 |
| _version_ | 1797540131769417728 |
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| author | Alina Cequier Carmen Sanz Clementina Rodellar Laura Barrachina |
| author_facet | Alina Cequier Carmen Sanz Clementina Rodellar Laura Barrachina |
| author_sort | Alina Cequier |
| collection | DOAJ |
| description | The differentiation ability of mesenchymal stem cells (MSCs) initially raised interest for treating musculoskeletal injuries in horses, but MSC paracrine activity has widened their scope for inflammatory and immune-mediated pathologies in both equine and human medicine. Furthermore, the similar etiopathogenesis of some diseases in both species has advanced the concept of “One Medicine, One Health”. This article reviews the current knowledge on the use of MSCs for equine pathologies beyond the locomotor system, highlighting the value of the horse as translational model. Ophthalmologic and reproductive disorders are among the most studied for MSC application. Equine asthma, equine metabolic syndrome, and endotoxemia have been less explored but offer an interesting scenario for human translation. The use of MSCs in wounds also provides a potential model for humans because of the healing particularities in both species. High-burden equine-specific pathologies such as laminitis have been suggested to benefit from MSC-therapy, and MSC application in challenging disorders such as neurologic conditions has been proposed. The available data are preliminary, however, and require further development to translate results into the clinic. Nevertheless, current evidence indicates a significant potential of equine MSCs to enlarge their range of application, with particular interest in pathologies analogous to human conditions. |
| first_indexed | 2024-03-10T12:55:41Z |
| format | Article |
| id | doaj.art-f64a96186b5f4f96bffd05788c4a673e |
| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-10T12:55:41Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj.art-f64a96186b5f4f96bffd05788c4a673e2023-11-21T11:58:21ZengMDPI AGAnimals2076-26152021-03-0111493110.3390/ani11040931The Usefulness of Mesenchymal Stem Cells beyond the Musculoskeletal System in HorsesAlina Cequier0Carmen Sanz1Clementina Rodellar2Laura Barrachina3Laboratorio de Genética Bioquímica LAGENBIO—Instituto de Investigación Sanitaria de Aragón (IIS)—Instituto Agroalimentario de Aragón (IA2), Universidad de Zaragoza, C/Miguel Servet, 177, 50013 Zaragoza, SpainServicio de Cirugía y Medicina Equina, Hospital Veterinario, Universidad de Zaragoza, C/Miguel Servet, 177, 50013 Zaragoza, SpainLaboratorio de Genética Bioquímica LAGENBIO—Instituto de Investigación Sanitaria de Aragón (IIS)—Instituto Agroalimentario de Aragón (IA2), Universidad de Zaragoza, C/Miguel Servet, 177, 50013 Zaragoza, SpainLaboratorio de Genética Bioquímica LAGENBIO—Instituto de Investigación Sanitaria de Aragón (IIS)—Instituto Agroalimentario de Aragón (IA2), Universidad de Zaragoza, C/Miguel Servet, 177, 50013 Zaragoza, SpainThe differentiation ability of mesenchymal stem cells (MSCs) initially raised interest for treating musculoskeletal injuries in horses, but MSC paracrine activity has widened their scope for inflammatory and immune-mediated pathologies in both equine and human medicine. Furthermore, the similar etiopathogenesis of some diseases in both species has advanced the concept of “One Medicine, One Health”. This article reviews the current knowledge on the use of MSCs for equine pathologies beyond the locomotor system, highlighting the value of the horse as translational model. Ophthalmologic and reproductive disorders are among the most studied for MSC application. Equine asthma, equine metabolic syndrome, and endotoxemia have been less explored but offer an interesting scenario for human translation. The use of MSCs in wounds also provides a potential model for humans because of the healing particularities in both species. High-burden equine-specific pathologies such as laminitis have been suggested to benefit from MSC-therapy, and MSC application in challenging disorders such as neurologic conditions has been proposed. The available data are preliminary, however, and require further development to translate results into the clinic. Nevertheless, current evidence indicates a significant potential of equine MSCs to enlarge their range of application, with particular interest in pathologies analogous to human conditions.https://www.mdpi.com/2076-2615/11/4/931One Medicinemesenchymal stem cellsimmune-mediated disordersophthalmologyreproductionequine asthma |
| spellingShingle | Alina Cequier Carmen Sanz Clementina Rodellar Laura Barrachina The Usefulness of Mesenchymal Stem Cells beyond the Musculoskeletal System in Horses Animals One Medicine mesenchymal stem cells immune-mediated disorders ophthalmology reproduction equine asthma |
| title | The Usefulness of Mesenchymal Stem Cells beyond the Musculoskeletal System in Horses |
| title_full | The Usefulness of Mesenchymal Stem Cells beyond the Musculoskeletal System in Horses |
| title_fullStr | The Usefulness of Mesenchymal Stem Cells beyond the Musculoskeletal System in Horses |
| title_full_unstemmed | The Usefulness of Mesenchymal Stem Cells beyond the Musculoskeletal System in Horses |
| title_short | The Usefulness of Mesenchymal Stem Cells beyond the Musculoskeletal System in Horses |
| title_sort | usefulness of mesenchymal stem cells beyond the musculoskeletal system in horses |
| topic | One Medicine mesenchymal stem cells immune-mediated disorders ophthalmology reproduction equine asthma |
| url | https://www.mdpi.com/2076-2615/11/4/931 |
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