Hypertensive effects of the iv administration of picomoles of ouabain
Ouabain, an endogenous digitalis compound, has been detected in nanomolar concentrations in the plasma of several mammals and is associated with the development of hypertension. In addition, plasma ouabain is increased in several hypertension models, and the acute or chronic administration of ouabai...
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Divulgação Científica
2011-09-01
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| Series: | Brazilian Journal of Medical and Biological Research |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000900015&lng=en&tlng=en |
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| author | A.S. Padilha M. Salaices D.V. Vassallo P.R. Batista F.D.M. Siman |
| author_facet | A.S. Padilha M. Salaices D.V. Vassallo P.R. Batista F.D.M. Siman |
| author_sort | A.S. Padilha |
| collection | DOAJ |
| description | Ouabain, an endogenous digitalis compound, has been detected in nanomolar concentrations in the plasma of several mammals and is associated with the development of hypertension. In addition, plasma ouabain is increased in several hypertension models, and the acute or chronic administration of ouabain increases blood pressure in rodents. These results suggest a possible association between ouabain and the genesis or development and maintenance of arterial hypertension. One explanation for this association is that ouabain binds to the α-subunit of the Na+ pump, inhibiting its activity. Inhibition of this pump increases intracellular Na+, which reduces the activity of the sarcolemmal Na+/Ca2+ exchanger and thereby reduces Ca2+ extrusion. Consequently, intracellular Ca2+ increases and is taken up by the sarcoplasmic reticulum, which, upon activation, releases more calcium and increases the vascular smooth muscle tone. In fact, acute treatment with ouabain enhances the vascular reactivity to vasopressor agents, increases the release of norepinephrine from the perivascular adrenergic nerve endings and promotes increases in the activity of endothelial angiotensin-converting enzyme and the local synthesis of angiotensin II in the tail vascular bed. Additionally, the hypertension induced by ouabain has been associated with central mechanisms that increase sympathetic tone, subsequent to the activation of the cerebral renin-angiotensin system. Thus, the association with peripheral mechanisms and central mechanisms, mainly involving the renin-angiotensin system, may contribute to the acute effects of ouabain-induced elevation of arterial blood pressure. |
| first_indexed | 2024-12-13T02:57:21Z |
| format | Article |
| id | doaj.art-f64c383d417b4175ba0db3de32b70c01 |
| institution | Directory Open Access Journal |
| issn | 1414-431X |
| language | English |
| last_indexed | 2024-12-13T02:57:21Z |
| publishDate | 2011-09-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-f64c383d417b4175ba0db3de32b70c012022-12-22T00:01:55ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research1414-431X2011-09-0144993393810.1590/S0100-879X2011000900015S0100-879X2011000900015Hypertensive effects of the iv administration of picomoles of ouabainA.S. Padilha0M. Salaices1D.V. Vassallo2P.R. Batista3F.D.M. Siman4Universidade Federal do Espírito SantoUniversidad Autónoma de MadridUniversidade Federal do Espírito SantoUniversidade Federal do Espírito SantoUniversidade Federal do Espírito SantoOuabain, an endogenous digitalis compound, has been detected in nanomolar concentrations in the plasma of several mammals and is associated with the development of hypertension. In addition, plasma ouabain is increased in several hypertension models, and the acute or chronic administration of ouabain increases blood pressure in rodents. These results suggest a possible association between ouabain and the genesis or development and maintenance of arterial hypertension. One explanation for this association is that ouabain binds to the α-subunit of the Na+ pump, inhibiting its activity. Inhibition of this pump increases intracellular Na+, which reduces the activity of the sarcolemmal Na+/Ca2+ exchanger and thereby reduces Ca2+ extrusion. Consequently, intracellular Ca2+ increases and is taken up by the sarcoplasmic reticulum, which, upon activation, releases more calcium and increases the vascular smooth muscle tone. In fact, acute treatment with ouabain enhances the vascular reactivity to vasopressor agents, increases the release of norepinephrine from the perivascular adrenergic nerve endings and promotes increases in the activity of endothelial angiotensin-converting enzyme and the local synthesis of angiotensin II in the tail vascular bed. Additionally, the hypertension induced by ouabain has been associated with central mechanisms that increase sympathetic tone, subsequent to the activation of the cerebral renin-angiotensin system. Thus, the association with peripheral mechanisms and central mechanisms, mainly involving the renin-angiotensin system, may contribute to the acute effects of ouabain-induced elevation of arterial blood pressure.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000900015&lng=en&tlng=enOuabainHypertensionVascular reactivityRenin-angiotensin system |
| spellingShingle | A.S. Padilha M. Salaices D.V. Vassallo P.R. Batista F.D.M. Siman Hypertensive effects of the iv administration of picomoles of ouabain Brazilian Journal of Medical and Biological Research Ouabain Hypertension Vascular reactivity Renin-angiotensin system |
| title | Hypertensive effects of the iv administration of picomoles of ouabain |
| title_full | Hypertensive effects of the iv administration of picomoles of ouabain |
| title_fullStr | Hypertensive effects of the iv administration of picomoles of ouabain |
| title_full_unstemmed | Hypertensive effects of the iv administration of picomoles of ouabain |
| title_short | Hypertensive effects of the iv administration of picomoles of ouabain |
| title_sort | hypertensive effects of the iv administration of picomoles of ouabain |
| topic | Ouabain Hypertension Vascular reactivity Renin-angiotensin system |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000900015&lng=en&tlng=en |
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