Orally Administered Koumine Persists Longer in the Plasma of Aged Rats Than That of Adult Rats as Assessed by Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry

Orally Administered Koumine Persists Longer in the Plasma of Aged Rats Than That of Adult Rats as Assessed by Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry

Aging leads to changes in nearly all pharmacokinetic phases. Koumine (KM), an alkaloid derived from Gelsemium elegans Benth., is effective against age-associated chronic diseases, but its dose proportionality following oral administration in aged individuals remains unknown. Herein, we established a...

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Bibliographic Details
Main Authors:	Li-Xiang Ye, Ying Xu, Shui-Hua Zhang, Da-Xuan Cao, Ling-Fan Chen, Yan-Ping Su, Hui-Hui Huang, Chang-Xi Yu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-07-01
Series:	Frontiers in Pharmacology
Subjects:	Koumine ultra-performance liquid chromatography-tandem mass spectrometry aging dose proportionality pharmacokinetics
Online Access:	https://www.frontiersin.org/article/10.3389/fphar.2020.01113/full

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