Clinical, Neuroradiological and Electroencephalographic Findings of Epileptic Patients with Malformation of Cortical Development
Objectives:We aimed to review the clinical, neuroradiological and electroencephalographic (EEG) findings of patients with epilepsy and malformation of cortical development (MCD).Methods:A retrospective analysis of the medical records of epilepsy outpatients was done. Patients with epilepsy, MCD, and...
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2019-08-01
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| Series: | Archives of Epilepsy |
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| Online Access: |
http://archepilepsy.org/archives/archive-detail/article-preview/clinical-neuroradiological-and-electroencephalogra/54833
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| _version_ | 1797767434096082944 |
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| author | Derya BAYRAM Kemai TUTKAVUL Yılmaz ÇETİNKAYA Tamer BAYRAM Hülya TİRELİ |
| author_facet | Derya BAYRAM Kemai TUTKAVUL Yılmaz ÇETİNKAYA Tamer BAYRAM Hülya TİRELİ |
| author_sort | Derya BAYRAM |
| collection | DOAJ |
| description | Objectives:We aimed to review the clinical, neuroradiological and electroencephalographic (EEG) findings of patients with epilepsy and malformation of cortical development (MCD).Methods:A retrospective analysis of the medical records of epilepsy outpatients was done. Patients with epilepsy, MCD, and ≥18 years of age were included and classified according to the Barkovich classification (BC).Results:The files of 2027 patients were assessed, and 17 out of 1395 epilepsy patients who were followed-up were found to have MCD. The mean age was 26.5 years. Ten patients were male and 7 were female. The mean time of seizure onset was 13 years. In terms of seizure type, 11 patients had focal, 10 had generalized tonic-clonic, 1 had absence, 1 had tonic-atonic, and 1 had myoclonic. MRI showed 7 patients with cortical dysplasia, 4 with heterotopia, 2 with periventricular nodular heterotopia, 2 with schiezencephaly, 2 with lissencephaly, 1 with agyria, 1 with pachygyria, 1 with macrogyria, 1 with polymicrogyria, and 1 with tuberous sclerosis. EEG revealed focal epileptiform discharges in 5 patients, high-frequency activity in 2, generalized epileptiform discharge in 1, diffuse disorganized background activity in 1, and focal disorganized background activity in 1. EEG was normal in 7 patients. Four of them were on monotherapy and 13 on polytherapy.Conclusion:The MCDs classified in group 1 and 2 according to BC are more frequent. Treatment-resistant or good responsive cases can be seen and seizures can begin at any age. We concluded that the prevalence of MCD is 1.21%. The spectrum of epilepsy seen is extensive and the most common type of MCD is focal cortical dysplasia. |
| first_indexed | 2024-03-12T20:39:41Z |
| format | Article |
| id | doaj.art-f64d58d7dc9043c8b197393ca6c9e292 |
| institution | Directory Open Access Journal |
| issn | 2792-0550 |
| language | English |
| last_indexed | 2024-03-12T20:39:41Z |
| publishDate | 2019-08-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Archives of Epilepsy |
| spelling | doaj.art-f64d58d7dc9043c8b197393ca6c9e2922023-08-01T11:13:18ZengGalenos YayineviArchives of Epilepsy2792-05502019-08-01252818710.14744/epilepsi.2018.1948413049054Clinical, Neuroradiological and Electroencephalographic Findings of Epileptic Patients with Malformation of Cortical DevelopmentDerya BAYRAM0Kemai TUTKAVUL1Yılmaz ÇETİNKAYA2Tamer BAYRAM3Hülya TİRELİ4 Department of Neurology, Health Sciences University Haydarpaşa Numune Training and Research Hospital, İstanbul, Turkey Department of Neurology, Health Sciences University Haydarpaşa Numune Training and Research Hospital, İstanbul, Turkey Department of Neurology, Health Sciences University Haydarpaşa Numune Training and Research Hospital, İstanbul, Turkey Department of Neurology, Health Sciences University Haydarpaşa Numune Training and Research Hospital, İstanbul, Turkey Department of Neurology, Health Sciences University Haydarpaşa Numune Training and Research Hospital, İstanbul, Turkey Objectives:We aimed to review the clinical, neuroradiological and electroencephalographic (EEG) findings of patients with epilepsy and malformation of cortical development (MCD).Methods:A retrospective analysis of the medical records of epilepsy outpatients was done. Patients with epilepsy, MCD, and ≥18 years of age were included and classified according to the Barkovich classification (BC).Results:The files of 2027 patients were assessed, and 17 out of 1395 epilepsy patients who were followed-up were found to have MCD. The mean age was 26.5 years. Ten patients were male and 7 were female. The mean time of seizure onset was 13 years. In terms of seizure type, 11 patients had focal, 10 had generalized tonic-clonic, 1 had absence, 1 had tonic-atonic, and 1 had myoclonic. MRI showed 7 patients with cortical dysplasia, 4 with heterotopia, 2 with periventricular nodular heterotopia, 2 with schiezencephaly, 2 with lissencephaly, 1 with agyria, 1 with pachygyria, 1 with macrogyria, 1 with polymicrogyria, and 1 with tuberous sclerosis. EEG revealed focal epileptiform discharges in 5 patients, high-frequency activity in 2, generalized epileptiform discharge in 1, diffuse disorganized background activity in 1, and focal disorganized background activity in 1. EEG was normal in 7 patients. Four of them were on monotherapy and 13 on polytherapy.Conclusion:The MCDs classified in group 1 and 2 according to BC are more frequent. Treatment-resistant or good responsive cases can be seen and seizures can begin at any age. We concluded that the prevalence of MCD is 1.21%. The spectrum of epilepsy seen is extensive and the most common type of MCD is focal cortical dysplasia. http://archepilepsy.org/archives/archive-detail/article-preview/clinical-neuroradiological-and-electroencephalogra/54833 epilepsymalformation of cortical developmentpolytherapy |
| spellingShingle | Derya BAYRAM Kemai TUTKAVUL Yılmaz ÇETİNKAYA Tamer BAYRAM Hülya TİRELİ Clinical, Neuroradiological and Electroencephalographic Findings of Epileptic Patients with Malformation of Cortical Development Archives of Epilepsy epilepsy malformation of cortical development polytherapy |
| title | Clinical, Neuroradiological and Electroencephalographic Findings of Epileptic Patients with Malformation of Cortical Development |
| title_full | Clinical, Neuroradiological and Electroencephalographic Findings of Epileptic Patients with Malformation of Cortical Development |
| title_fullStr | Clinical, Neuroradiological and Electroencephalographic Findings of Epileptic Patients with Malformation of Cortical Development |
| title_full_unstemmed | Clinical, Neuroradiological and Electroencephalographic Findings of Epileptic Patients with Malformation of Cortical Development |
| title_short | Clinical, Neuroradiological and Electroencephalographic Findings of Epileptic Patients with Malformation of Cortical Development |
| title_sort | clinical neuroradiological and electroencephalographic findings of epileptic patients with malformation of cortical development |
| topic | epilepsy malformation of cortical development polytherapy |
| url |
http://archepilepsy.org/archives/archive-detail/article-preview/clinical-neuroradiological-and-electroencephalogra/54833
|
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