Right heart condition in patients with COVID-19 pneumonia
Aim. To assess right heart condition in patients with coronavirus disease 2019 (COVID-19) pneumonia.Material and methods. One hundred and five patients with COVID-19 pneumonia were divided into 3 groups depending on the involvement of lung parenchyma: group I — 0-25%, II — 25-50%, III — 50-75%. The...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
«FIRMA «SILICEA» LLC
2021-12-01
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| Series: | Российский кардиологический журнал |
| Subjects: | |
| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/4733 |
| _version_ | 1826561027065511936 |
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| author | N. G. Poteshkina N. S. Krylova A. A. Karasev T. A. Nikitina A. M. Svanadze I. P. Beloglazova E. A. Kovalevskaya K. A. Barakhanov M. A. Lysenko A. M. Ibragimova V. N. Smorshchok |
| author_facet | N. G. Poteshkina N. S. Krylova A. A. Karasev T. A. Nikitina A. M. Svanadze I. P. Beloglazova E. A. Kovalevskaya K. A. Barakhanov M. A. Lysenko A. M. Ibragimova V. N. Smorshchok |
| author_sort | N. G. Poteshkina |
| collection | DOAJ |
| description | Aim. To assess right heart condition in patients with coronavirus disease 2019 (COVID-19) pneumonia.Material and methods. One hundred and five patients with COVID-19 pneumonia were divided into 3 groups depending on the involvement of lung parenchyma: group I — 0-25%, II — 25-50%, III — 50-75%. The clinical status of patients was assessed using the NEWS2 and SHOKS-COVID scales. A complete blood count and biochemical blood tests were performed to determine the level of N-terminal pro-brain natriuretic peptide (NT-proBNP) and troponin I. Echocardiography was performed to assess the right heart structural, hemodynamic and functional parameters.Results. In patients with COVID-19 pneumonia, with an increase in lung parenchyma involvement, the intensity of systemic inflammatory response increased: C-reactive protein, group I — (4 [1,9; 35] mg/l), in III — (70,5 [33; 144] mg/l) (pI-III=0,012); myocardial stress marker level increased: NT-proBNP, group I — 77 [48; 150] ng/l, group III — 165 [100; 287] ng/l (pI-III=0,047). The dependence of NT-proBNP on C-reactive protein level was revealed (r=0,335, p=0,03). Intergroup comparison did not reveal significant differences between the main right heart functional parameters: TAPSE, Tei index (PW and TDI), FAC of the right ventricle (RV) (p>0,05). However, differences in the tricuspid annular peaks were found as follows: group I — 0,14 [0,12; 0,14] m/s, group II — 0,14 [0,12; 0,15] m/s, group III — 0,16 [0,14; 0,17] m/s (pI-II=0,012, pI-III=0,014) and RV global longitudinal strain: group I — 19,63±7,72%, group III — 27,4±5,93% (pI-III=0,014). The relationship between the RV global longitudinal strain and SHOKS-COVID score was confirmed (r=0,381; p=0,024).Conclusion. Patients with COVID-19 pneumonia showed no signs of right heart dysfunction. The development of RV hyperfunction was noted. Most likely, this is a compensatory mechanism in response to acute RV afterload. NT-proBNP increase under conditions of an inflammatory response may indicate myocardial stress. The results obtained allow to expand our understanding of the right heart condition in patients with COVID-19 pneumonia. |
| first_indexed | 2024-04-09T20:43:59Z |
| format | Article |
| id | doaj.art-f64d5d720f654021a9a75d20a9c6d0ec |
| institution | Directory Open Access Journal |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| last_indexed | 2025-03-14T09:25:38Z |
| publishDate | 2021-12-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj.art-f64d5d720f654021a9a75d20a9c6d0ec2025-03-02T11:42:56Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202021-12-01261110.15829/1560-4071-2021-47333409Right heart condition in patients with COVID-19 pneumoniaN. G. Poteshkina0N. S. Krylova1A. A. Karasev2T. A. Nikitina3A. M. Svanadze4I. P. Beloglazova5E. A. Kovalevskaya6K. A. Barakhanov7M. A. Lysenko8A. M. Ibragimova9V. N. Smorshchok10Pirogov Russian National Research Medical University; City Clinical Hospital № 52Pirogov Russian National Research Medical University; City Clinical Hospital № 52Pirogov Russian National Research Medical University (RNRMU)City Clinical Hospital №52Pirogov Russian National Research Medical University; City Clinical Hospital № 52Pirogov Russian National Research Medical University; City Clinical Hospital № 52City Clinical Hospital № 52City Clinical Hospital № 52Pirogov Russian National Research Medical University; City Clinical Hospital № 52Pirogov Russian National Research Medical UniversityCity Clinical Hospital № 52Aim. To assess right heart condition in patients with coronavirus disease 2019 (COVID-19) pneumonia.Material and methods. One hundred and five patients with COVID-19 pneumonia were divided into 3 groups depending on the involvement of lung parenchyma: group I — 0-25%, II — 25-50%, III — 50-75%. The clinical status of patients was assessed using the NEWS2 and SHOKS-COVID scales. A complete blood count and biochemical blood tests were performed to determine the level of N-terminal pro-brain natriuretic peptide (NT-proBNP) and troponin I. Echocardiography was performed to assess the right heart structural, hemodynamic and functional parameters.Results. In patients with COVID-19 pneumonia, with an increase in lung parenchyma involvement, the intensity of systemic inflammatory response increased: C-reactive protein, group I — (4 [1,9; 35] mg/l), in III — (70,5 [33; 144] mg/l) (pI-III=0,012); myocardial stress marker level increased: NT-proBNP, group I — 77 [48; 150] ng/l, group III — 165 [100; 287] ng/l (pI-III=0,047). The dependence of NT-proBNP on C-reactive protein level was revealed (r=0,335, p=0,03). Intergroup comparison did not reveal significant differences between the main right heart functional parameters: TAPSE, Tei index (PW and TDI), FAC of the right ventricle (RV) (p>0,05). However, differences in the tricuspid annular peaks were found as follows: group I — 0,14 [0,12; 0,14] m/s, group II — 0,14 [0,12; 0,15] m/s, group III — 0,16 [0,14; 0,17] m/s (pI-II=0,012, pI-III=0,014) and RV global longitudinal strain: group I — 19,63±7,72%, group III — 27,4±5,93% (pI-III=0,014). The relationship between the RV global longitudinal strain and SHOKS-COVID score was confirmed (r=0,381; p=0,024).Conclusion. Patients with COVID-19 pneumonia showed no signs of right heart dysfunction. The development of RV hyperfunction was noted. Most likely, this is a compensatory mechanism in response to acute RV afterload. NT-proBNP increase under conditions of an inflammatory response may indicate myocardial stress. The results obtained allow to expand our understanding of the right heart condition in patients with COVID-19 pneumonia.https://russjcardiol.elpub.ru/jour/article/view/4733covid-19echocardiographynt-probnpright heartglobal longitudinal strain |
| spellingShingle | N. G. Poteshkina N. S. Krylova A. A. Karasev T. A. Nikitina A. M. Svanadze I. P. Beloglazova E. A. Kovalevskaya K. A. Barakhanov M. A. Lysenko A. M. Ibragimova V. N. Smorshchok Right heart condition in patients with COVID-19 pneumonia Российский кардиологический журнал covid-19 echocardiography nt-probnp right heart global longitudinal strain |
| title | Right heart condition in patients with COVID-19 pneumonia |
| title_full | Right heart condition in patients with COVID-19 pneumonia |
| title_fullStr | Right heart condition in patients with COVID-19 pneumonia |
| title_full_unstemmed | Right heart condition in patients with COVID-19 pneumonia |
| title_short | Right heart condition in patients with COVID-19 pneumonia |
| title_sort | right heart condition in patients with covid 19 pneumonia |
| topic | covid-19 echocardiography nt-probnp right heart global longitudinal strain |
| url | https://russjcardiol.elpub.ru/jour/article/view/4733 |
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