Dissociable neural processes during risky decision-making in individuals with Internet-gaming disorder
Risk-taking is purported to be central to addictive behaviors. However, for Internet gaming disorder (IGD), a condition conceptualized as a behavioral addiction, the neural processes underlying impaired decision-making (risk evaluation and outcome processing) related to gains and losses have not bee...
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| Format: | Article |
| Language: | English |
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Elsevier
2017-01-01
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| Series: | NeuroImage: Clinical |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158217300700 |
| _version_ | 1811230399219630080 |
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| author | Lu Liu Gui Xue Marc N. Potenza Jin-Tao Zhang Yuan-Wei Yao Cui-Cui Xia Jing Lan Shan-Shan Ma Xiao-Yi Fang |
| author_facet | Lu Liu Gui Xue Marc N. Potenza Jin-Tao Zhang Yuan-Wei Yao Cui-Cui Xia Jing Lan Shan-Shan Ma Xiao-Yi Fang |
| author_sort | Lu Liu |
| collection | DOAJ |
| description | Risk-taking is purported to be central to addictive behaviors. However, for Internet gaming disorder (IGD), a condition conceptualized as a behavioral addiction, the neural processes underlying impaired decision-making (risk evaluation and outcome processing) related to gains and losses have not been systematically investigated. Forty-one males with IGD and 27 healthy comparison (HC) male participants were recruited, and the cups task was used to identify neural processes associated with gain- and loss-related risk- and outcome-processing in IGD. During risk evaluation, the IGD group, compared to the HC participants, showed weaker modulation for experienced risk within the bilateral dorsolateral prefrontal cortex (DLPFC) (t = −4.07; t = −3.94; PFWE < 0.05) and inferior parietal lobule (IPL) (t = −4.08; t = −4.08; PFWE < 0.05) for potential losses. The modulation of the left DLPFC and bilateral IPL activation were negatively related to addiction severity within the IGD group (r = −0.55; r = −0.61; r = −0.51; PFWE < 0.05). During outcome processing, the IGD group presented greater responses for the experienced reward within the ventral striatum, ventromedial prefrontal cortex, and orbitofrontal cortex (OFC) (t = 5.04, PFWE < 0.05) for potential gains, as compared to HC participants. Within the IGD group, the increased reward-related activity in the right OFC was positively associated with severity of IGD (r = 0.51, PFWE < 0.05). These results provide a neurobiological foundation for decision-making deficits in individuals with IGD and suggest an imbalance between hypersensitivity for reward and weaker risk experience and self-control for loss. The findings suggest a biological mechanism for why individuals with IGD may persist in game-seeking behavior despite negative consequences, and treatment development strategies may focus on targeting these neural pathways in this population. |
| first_indexed | 2024-04-12T10:28:46Z |
| format | Article |
| id | doaj.art-f64ecadaebc84484b7849267e5ba0007 |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-04-12T10:28:46Z |
| publishDate | 2017-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-f64ecadaebc84484b7849267e5ba00072022-12-22T03:36:55ZengElsevierNeuroImage: Clinical2213-15822017-01-0114C74174910.1016/j.nicl.2017.03.010Dissociable neural processes during risky decision-making in individuals with Internet-gaming disorderLu Liu0Gui Xue1Marc N. Potenza2Jin-Tao Zhang3Yuan-Wei Yao4Cui-Cui Xia5Jing Lan6Shan-Shan Ma7Xiao-Yi Fang8Institute of Developmental Psychology, Beijing Normal University, Beijing 100875, ChinaState Key Laboratory of Cognitive Neuroscience, Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, ChinaDepartments of Psychiatry and Neuroscience, the Child Study Center, the National Center on Addiction and Substance Abuse, Yale University School of Medicine, New Haven, CT 06519, USAState Key Laboratory of Cognitive Neuroscience, Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, ChinaState Key Laboratory of Cognitive Neuroscience, Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, ChinaInstitute of Developmental Psychology, Beijing Normal University, Beijing 100875, ChinaInstitute of Developmental Psychology, Beijing Normal University, Beijing 100875, ChinaState Key Laboratory of Cognitive Neuroscience, Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, ChinaInstitute of Developmental Psychology, Beijing Normal University, Beijing 100875, ChinaRisk-taking is purported to be central to addictive behaviors. However, for Internet gaming disorder (IGD), a condition conceptualized as a behavioral addiction, the neural processes underlying impaired decision-making (risk evaluation and outcome processing) related to gains and losses have not been systematically investigated. Forty-one males with IGD and 27 healthy comparison (HC) male participants were recruited, and the cups task was used to identify neural processes associated with gain- and loss-related risk- and outcome-processing in IGD. During risk evaluation, the IGD group, compared to the HC participants, showed weaker modulation for experienced risk within the bilateral dorsolateral prefrontal cortex (DLPFC) (t = −4.07; t = −3.94; PFWE < 0.05) and inferior parietal lobule (IPL) (t = −4.08; t = −4.08; PFWE < 0.05) for potential losses. The modulation of the left DLPFC and bilateral IPL activation were negatively related to addiction severity within the IGD group (r = −0.55; r = −0.61; r = −0.51; PFWE < 0.05). During outcome processing, the IGD group presented greater responses for the experienced reward within the ventral striatum, ventromedial prefrontal cortex, and orbitofrontal cortex (OFC) (t = 5.04, PFWE < 0.05) for potential gains, as compared to HC participants. Within the IGD group, the increased reward-related activity in the right OFC was positively associated with severity of IGD (r = 0.51, PFWE < 0.05). These results provide a neurobiological foundation for decision-making deficits in individuals with IGD and suggest an imbalance between hypersensitivity for reward and weaker risk experience and self-control for loss. The findings suggest a biological mechanism for why individuals with IGD may persist in game-seeking behavior despite negative consequences, and treatment development strategies may focus on targeting these neural pathways in this population.http://www.sciencedirect.com/science/article/pii/S2213158217300700fMRIInternet gaming disorderOutcome processingRisky decision-makingRisk evaluation |
| spellingShingle | Lu Liu Gui Xue Marc N. Potenza Jin-Tao Zhang Yuan-Wei Yao Cui-Cui Xia Jing Lan Shan-Shan Ma Xiao-Yi Fang Dissociable neural processes during risky decision-making in individuals with Internet-gaming disorder NeuroImage: Clinical fMRI Internet gaming disorder Outcome processing Risky decision-making Risk evaluation |
| title | Dissociable neural processes during risky decision-making in individuals with Internet-gaming disorder |
| title_full | Dissociable neural processes during risky decision-making in individuals with Internet-gaming disorder |
| title_fullStr | Dissociable neural processes during risky decision-making in individuals with Internet-gaming disorder |
| title_full_unstemmed | Dissociable neural processes during risky decision-making in individuals with Internet-gaming disorder |
| title_short | Dissociable neural processes during risky decision-making in individuals with Internet-gaming disorder |
| title_sort | dissociable neural processes during risky decision making in individuals with internet gaming disorder |
| topic | fMRI Internet gaming disorder Outcome processing Risky decision-making Risk evaluation |
| url | http://www.sciencedirect.com/science/article/pii/S2213158217300700 |
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