Predominant Mutations of SARS-CoV-2: Their Geographical Distribution and Potential Consequences
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) emerged in late December 2019 in Wuhan, China. More than 83 million people have been infected, and more than 1.8 million people have died, as reported to the World Health Organization on the 3rd of January, 2021. Analysis of genetic variat...
| Main Authors: | , , |
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| Format: | Article |
| Language: | Turkish |
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Galenos Yayinevi
2021-12-01
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| Series: | Mediterranean Journal of Infection, Microbes and Antimicrobials |
| Subjects: | |
| Online Access: | http://mjima.org/abstract.php?id=232 |
| _version_ | 1828023834806059008 |
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| author | Sezin ÜNLÜ Aylin ÜSKÜDAR-GÜÇLÜ Ahmet BAŞUSTAOĞLU |
| author_facet | Sezin ÜNLÜ Aylin ÜSKÜDAR-GÜÇLÜ Ahmet BAŞUSTAOĞLU |
| author_sort | Sezin ÜNLÜ |
| collection | DOAJ |
| description | Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) emerged in late December 2019 in Wuhan, China. More than 83 million people have been infected, and more than 1.8 million people have died, as reported to the World Health Organization on the 3rd of January, 2021. Analysis of genetic variations is critical for understanding the spreading pattern of SARS-CoV-2 across several countries. This review aimed to gather information about the prominent mutations of SARS-CoV-2 by analyzing the origin, viral pathogenesis, and mutation rate. Moreover, we concluded their potential impacts on SARS-CoV-2 therapeutics. Mutations in the spike protein (D614G, N501Y, E484K, A222V, S477N, and G485R), ORF1ab (P323L, N628N, Y455Y, A97V, and F106F), nucleocapsid protein (R203K and G204R), ORF8 (L84S), and ORF3a (Q57H and G251V) were examined in this review by analyzing relevant articles from the beginning of the current pandemic to the most recent date. A detailed analysis of articles demonstrates that D614G is the major variation distributed globally, and its frequency increased rapidly from early in March, followed by several other variations in either spike or different proteins. In addition, it was seen that the currently circulating N501Y and E484K variants revealed a public concern regarding vaccines’ efficacy. Investigation of variations of SARS-CoV-2 would lead to understanding their potential mechanism of action against SARS-CoV-2, thereby suggesting suitable therapeutics. Several mechanisms were suggested to have a role in SARS-CoV-2 mutation rate and evolution. Possible therapeutics and vaccines against SARS-CoV-2 were proposed. |
| first_indexed | 2024-04-10T12:34:44Z |
| format | Article |
| id | doaj.art-f64f7fbfbed04f4291c91769f5a98056 |
| institution | Directory Open Access Journal |
| issn | 2147-673X |
| language | Turkish |
| last_indexed | 2024-04-10T12:34:44Z |
| publishDate | 2021-12-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Mediterranean Journal of Infection, Microbes and Antimicrobials |
| spelling | doaj.art-f64f7fbfbed04f4291c91769f5a980562023-02-15T16:14:43ZturGalenos YayineviMediterranean Journal of Infection, Microbes and Antimicrobials2147-673X2021-12-0110110.4274/mjima.galenos.2021.2021.15Predominant Mutations of SARS-CoV-2: Their Geographical Distribution and Potential ConsequencesSezin ÜNLÜ0https://orcid.org/0000-0001-7490-7981Aylin ÜSKÜDAR-GÜÇLÜ1https://orcid.org/0000-0002-1872-028XAhmet BAŞUSTAOĞLU2https://orcid.org/0000-0002-2571-0637Başkent University Faculty of Medicine, Department of Medical Microbiology, Ankara, TurkeyBaşkent University Faculty of Medicine, Department of Medical Microbiology, Ankara, TurkeyBaşkent University Faculty of Medicine, Department of Medical Microbiology, Ankara, TurkeySevere Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) emerged in late December 2019 in Wuhan, China. More than 83 million people have been infected, and more than 1.8 million people have died, as reported to the World Health Organization on the 3rd of January, 2021. Analysis of genetic variations is critical for understanding the spreading pattern of SARS-CoV-2 across several countries. This review aimed to gather information about the prominent mutations of SARS-CoV-2 by analyzing the origin, viral pathogenesis, and mutation rate. Moreover, we concluded their potential impacts on SARS-CoV-2 therapeutics. Mutations in the spike protein (D614G, N501Y, E484K, A222V, S477N, and G485R), ORF1ab (P323L, N628N, Y455Y, A97V, and F106F), nucleocapsid protein (R203K and G204R), ORF8 (L84S), and ORF3a (Q57H and G251V) were examined in this review by analyzing relevant articles from the beginning of the current pandemic to the most recent date. A detailed analysis of articles demonstrates that D614G is the major variation distributed globally, and its frequency increased rapidly from early in March, followed by several other variations in either spike or different proteins. In addition, it was seen that the currently circulating N501Y and E484K variants revealed a public concern regarding vaccines’ efficacy. Investigation of variations of SARS-CoV-2 would lead to understanding their potential mechanism of action against SARS-CoV-2, thereby suggesting suitable therapeutics. Several mechanisms were suggested to have a role in SARS-CoV-2 mutation rate and evolution. Possible therapeutics and vaccines against SARS-CoV-2 were proposed.http://mjima.org/abstract.php?id=232sars-cov-2genomic variationsimpacts of sars-cov-2 mutationsgeographical distribution |
| spellingShingle | Sezin ÜNLÜ Aylin ÜSKÜDAR-GÜÇLÜ Ahmet BAŞUSTAOĞLU Predominant Mutations of SARS-CoV-2: Their Geographical Distribution and Potential Consequences Mediterranean Journal of Infection, Microbes and Antimicrobials sars-cov-2 genomic variations impacts of sars-cov-2 mutations geographical distribution |
| title | Predominant Mutations of SARS-CoV-2: Their Geographical Distribution and Potential Consequences |
| title_full | Predominant Mutations of SARS-CoV-2: Their Geographical Distribution and Potential Consequences |
| title_fullStr | Predominant Mutations of SARS-CoV-2: Their Geographical Distribution and Potential Consequences |
| title_full_unstemmed | Predominant Mutations of SARS-CoV-2: Their Geographical Distribution and Potential Consequences |
| title_short | Predominant Mutations of SARS-CoV-2: Their Geographical Distribution and Potential Consequences |
| title_sort | predominant mutations of sars cov 2 their geographical distribution and potential consequences |
| topic | sars-cov-2 genomic variations impacts of sars-cov-2 mutations geographical distribution |
| url | http://mjima.org/abstract.php?id=232 |
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