Role of the cardiac extracellular matrix in the onset and progression of heart failure
Any cardiovascular disease leads to heart failure (HF) — a complex clinical syndrome, the course of which is probably specified by the influence of cardiovascular factors on cardiac extracellular matrix (ECM).The presented literature data indicate that the cardiac ECM is an important pathophysiologi...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
«FIRMA «SILICEA» LLC
2021-07-01
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| Series: | Российский кардиологический журнал |
| Subjects: | |
| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/4362 |
| _version_ | 1797856720783933440 |
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| author | N. N. Ilov K. Sh. Arnaudova A. A. Nechepurenko A. L. Yasenyavskaya O. A. Bashkina M. A. Samotrueva |
| author_facet | N. N. Ilov K. Sh. Arnaudova A. A. Nechepurenko A. L. Yasenyavskaya O. A. Bashkina M. A. Samotrueva |
| author_sort | N. N. Ilov |
| collection | DOAJ |
| description | Any cardiovascular disease leads to heart failure (HF) — a complex clinical syndrome, the course of which is probably specified by the influence of cardiovascular factors on cardiac extracellular matrix (ECM).The presented literature data indicate that the cardiac ECM is an important pathophysiological link in the onset and progression of HF. The morphological and electrical remodeling negatively affects the systolic and diastolic functions of the heart. Impaired myocardial blood delivery, cellular maladaptation, atrial and ventricular arrhythmias are additional mechanisms of the influence of myocardial fibrosis on HF course.Understanding this role of ECM and the development of algorithms for verifying the individual status of ECM in cardiovascular patients can provide additional data on the course of HF, help to assess the risk of adverse cardiovascular events and effectively control the ongoing pharmacological and non-drug therapy. |
| first_indexed | 2024-04-09T20:45:07Z |
| format | Article |
| id | doaj.art-f65093942a2742e690054a500b10d6a5 |
| institution | Directory Open Access Journal |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| last_indexed | 2024-04-09T20:45:07Z |
| publishDate | 2021-07-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj.art-f65093942a2742e690054a500b10d6a52023-03-29T21:23:38Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202021-07-01262S10.15829/1560-4071-2021-43623277Role of the cardiac extracellular matrix in the onset and progression of heart failureN. N. Ilov0K. Sh. Arnaudova1A. A. Nechepurenko2A. L. Yasenyavskaya3O. A. Bashkina4M. A. Samotrueva5Astrakhan State Medical University; Federal Center for Cardiovascular SurgeryAstrakhan State Medical UniversityFederal Center for Cardiovascular SurgeryAstrakhan State Medical UniversityAstrakhan State Medical UniversityAstrakhan State Medical UniversityAny cardiovascular disease leads to heart failure (HF) — a complex clinical syndrome, the course of which is probably specified by the influence of cardiovascular factors on cardiac extracellular matrix (ECM).The presented literature data indicate that the cardiac ECM is an important pathophysiological link in the onset and progression of HF. The morphological and electrical remodeling negatively affects the systolic and diastolic functions of the heart. Impaired myocardial blood delivery, cellular maladaptation, atrial and ventricular arrhythmias are additional mechanisms of the influence of myocardial fibrosis on HF course.Understanding this role of ECM and the development of algorithms for verifying the individual status of ECM in cardiovascular patients can provide additional data on the course of HF, help to assess the risk of adverse cardiovascular events and effectively control the ongoing pharmacological and non-drug therapy.https://russjcardiol.elpub.ru/jour/article/view/4362cardiac extracellular matrixmyocardial fibrosisheart failure |
| spellingShingle | N. N. Ilov K. Sh. Arnaudova A. A. Nechepurenko A. L. Yasenyavskaya O. A. Bashkina M. A. Samotrueva Role of the cardiac extracellular matrix in the onset and progression of heart failure Российский кардиологический журнал cardiac extracellular matrix myocardial fibrosis heart failure |
| title | Role of the cardiac extracellular matrix in the onset and progression of heart failure |
| title_full | Role of the cardiac extracellular matrix in the onset and progression of heart failure |
| title_fullStr | Role of the cardiac extracellular matrix in the onset and progression of heart failure |
| title_full_unstemmed | Role of the cardiac extracellular matrix in the onset and progression of heart failure |
| title_short | Role of the cardiac extracellular matrix in the onset and progression of heart failure |
| title_sort | role of the cardiac extracellular matrix in the onset and progression of heart failure |
| topic | cardiac extracellular matrix myocardial fibrosis heart failure |
| url | https://russjcardiol.elpub.ru/jour/article/view/4362 |
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