Unlocking the mystery of the role of Vitamin D in iron deficiency anemia in antenatal women: a case control study in a tertiary care hospital in New Delhi
Abstract Background Vitamin D deficiency and anemia are clinical conditions that coexist during pregnancy. A high prevalence of Vitamin D deficiency ranging from 50 to 94% is seen throughout the country. The aim of the study was to discover the association between Vitamin D status and iron deficienc...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-10-01
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| Series: | BMC Pregnancy and Childbirth |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12884-023-06047-w |
| _version_ | 1797555845197725696 |
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| author | Tanishq Hitesh Ritu Khatuja Poonam Agrawal Deepak Dhamnetiya Ravi Prakash Jha Prachi Renjhen |
| author_facet | Tanishq Hitesh Ritu Khatuja Poonam Agrawal Deepak Dhamnetiya Ravi Prakash Jha Prachi Renjhen |
| author_sort | Tanishq Hitesh |
| collection | DOAJ |
| description | Abstract Background Vitamin D deficiency and anemia are clinical conditions that coexist during pregnancy. A high prevalence of Vitamin D deficiency ranging from 50 to 94% is seen throughout the country. The aim of the study was to discover the association between Vitamin D status and iron deficiency anemia during pregnancy. Improving the vitamin D status of pregnant women is crucial to prevent iron deficiency anemia and can improve maternal and fetal outcomes. Methods A case–control study including 94 primigravida women of age within the age group 18 to 30 years, divided into two groups: a Case Group of 48 patients with already diagnosed iron deficiency anemia (mild to moderate) and a Control Group of 46 antenatal women with normal hemoglobin levels. Data on sociodemographic, clinical characteristics, and the levels of 25(OH) Vitamin D was estimated in both the groups. The association of 25(OH)D levels and anemia was then determined using suitable statistical analysis. Results Among pregnant women affected with anemia, 75% of women had serum Vitamin D concentrations < 20 ng/ml compared to 52.2% of women in the controls. Maternal serum vitamin D level was significantly lower in pregnant women affected with anemia (19.61 ± 13.12) as compared to control (29.43 ± 24.05); (p = 0.024). A positive correlation was found between hemoglobin and vitamin D levels in pregnant women (Pearson’s r = 0.200, p = 0.05). Conclusions These findings provide evidence suggesting that Vitamin D deficiency or insufficiency during pregnancy may be a risk factor for anemia and correction of Vitamin D levels can improve hemoglobin levels. Educational efforts should be made to include safe vitamin D intake in antenatal care. |
| first_indexed | 2024-03-10T16:53:27Z |
| format | Article |
| id | doaj.art-f653550bf936450e92d5cdbfb9d69c2b |
| institution | Directory Open Access Journal |
| issn | 1471-2393 |
| language | English |
| last_indexed | 2024-03-10T16:53:27Z |
| publishDate | 2023-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pregnancy and Childbirth |
| spelling | doaj.art-f653550bf936450e92d5cdbfb9d69c2b2023-11-20T11:13:39ZengBMCBMC Pregnancy and Childbirth1471-23932023-10-012311810.1186/s12884-023-06047-wUnlocking the mystery of the role of Vitamin D in iron deficiency anemia in antenatal women: a case control study in a tertiary care hospital in New DelhiTanishq Hitesh0Ritu Khatuja1Poonam Agrawal2Deepak Dhamnetiya3Ravi Prakash Jha4Prachi Renjhen5Dr. Baba Saheb Ambedkar Medical College and HospitalDepartment of Obstetrics and Gynaecology, Dr. Baba Saheb Ambedkar Medical College and HospitalDepartment of Biochemistry, Dr. Baba Saheb Ambedkar Medical College and HospitalDepartment of Community Medicine, Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia HospitalDepartment of Community Medicine, Dr. Baba Saheb Ambedkar Medical College and HospitalDepartment of Obstetrics and Gynaecology, Dr. Baba Saheb Ambedkar Medical College and HospitalAbstract Background Vitamin D deficiency and anemia are clinical conditions that coexist during pregnancy. A high prevalence of Vitamin D deficiency ranging from 50 to 94% is seen throughout the country. The aim of the study was to discover the association between Vitamin D status and iron deficiency anemia during pregnancy. Improving the vitamin D status of pregnant women is crucial to prevent iron deficiency anemia and can improve maternal and fetal outcomes. Methods A case–control study including 94 primigravida women of age within the age group 18 to 30 years, divided into two groups: a Case Group of 48 patients with already diagnosed iron deficiency anemia (mild to moderate) and a Control Group of 46 antenatal women with normal hemoglobin levels. Data on sociodemographic, clinical characteristics, and the levels of 25(OH) Vitamin D was estimated in both the groups. The association of 25(OH)D levels and anemia was then determined using suitable statistical analysis. Results Among pregnant women affected with anemia, 75% of women had serum Vitamin D concentrations < 20 ng/ml compared to 52.2% of women in the controls. Maternal serum vitamin D level was significantly lower in pregnant women affected with anemia (19.61 ± 13.12) as compared to control (29.43 ± 24.05); (p = 0.024). A positive correlation was found between hemoglobin and vitamin D levels in pregnant women (Pearson’s r = 0.200, p = 0.05). Conclusions These findings provide evidence suggesting that Vitamin D deficiency or insufficiency during pregnancy may be a risk factor for anemia and correction of Vitamin D levels can improve hemoglobin levels. Educational efforts should be made to include safe vitamin D intake in antenatal care.https://doi.org/10.1186/s12884-023-06047-wPregnant womenVitamin D deficiencyAnemiaObstetricsMaternalDeveloping countries |
| spellingShingle | Tanishq Hitesh Ritu Khatuja Poonam Agrawal Deepak Dhamnetiya Ravi Prakash Jha Prachi Renjhen Unlocking the mystery of the role of Vitamin D in iron deficiency anemia in antenatal women: a case control study in a tertiary care hospital in New Delhi BMC Pregnancy and Childbirth Pregnant women Vitamin D deficiency Anemia Obstetrics Maternal Developing countries |
| title | Unlocking the mystery of the role of Vitamin D in iron deficiency anemia in antenatal women: a case control study in a tertiary care hospital in New Delhi |
| title_full | Unlocking the mystery of the role of Vitamin D in iron deficiency anemia in antenatal women: a case control study in a tertiary care hospital in New Delhi |
| title_fullStr | Unlocking the mystery of the role of Vitamin D in iron deficiency anemia in antenatal women: a case control study in a tertiary care hospital in New Delhi |
| title_full_unstemmed | Unlocking the mystery of the role of Vitamin D in iron deficiency anemia in antenatal women: a case control study in a tertiary care hospital in New Delhi |
| title_short | Unlocking the mystery of the role of Vitamin D in iron deficiency anemia in antenatal women: a case control study in a tertiary care hospital in New Delhi |
| title_sort | unlocking the mystery of the role of vitamin d in iron deficiency anemia in antenatal women a case control study in a tertiary care hospital in new delhi |
| topic | Pregnant women Vitamin D deficiency Anemia Obstetrics Maternal Developing countries |
| url | https://doi.org/10.1186/s12884-023-06047-w |
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