New drug-like small molecule antagonizes phosphatidylinositol (3,4,5)-trisphosphate (PIP3) in patients with conotruncal heart defects

New drug-like small molecule antagonizes phosphatidylinositol (3,4,5)-trisphosphate (PIP3) in patients with conotruncal heart defects

الملخص: أهداف البحث: عيوب القلب الوعائية وراثية بشكل كبير وحوالي ثلث عيوب القلب الخلقية ناتجة عن عيوب القلب الوعائية. باستخدام التحليل اللاحق لعيوب القلب المخروطية -بيانات دراسة الترابط الجينومي الكامل ذات الصلة، تم افتراض مسار جديد مفترض لنقل الإشارات، يسمى ''فارس2-بك3كا-أ ك ت''...

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Bibliographic Details
Main Authors:	Alaaeldin G. Fayez, PhD, Nora N. Esmaiel, PhD, Engy A. Ashaat, MD, Miral M. Refeat, PhD, Randa S. Lotfy, PhD, Haiam Abdel Raouf, PhD, Mona O. El Ruby, MD
Format:	Article
Language:	English
Published:	Elsevier 2023-12-01
Series:	Journal of Taibah University Medical Sciences
Subjects:	Akt Conotruncal heart defects Drug design PIP3 antagonist Pleckstrin homology domain Signal transduction pathway
Online Access:	http://www.sciencedirect.com/science/article/pii/S1658361223000653

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