Chronic myeloid leukemia: In pursuit of perfection
The resounding success of imatinib (IM) as front line treatment in patients with chronic myeloid leukemia (CML) has certainly made a paradigm shift in the therapeutic algorithm of this disorder. The precise targeting of the BCR-ABL oncogene in CML has entitled it to be the poster child of translatio...
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| Format: | Article |
| Language: | English |
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2012-07-01
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| Series: | South Asian Journal of Cancer |
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| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.4103/2278-330X.96498 |
| _version_ | 1829503798603677696 |
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| author | Vishal Jayakar |
| author_facet | Vishal Jayakar |
| author_sort | Vishal Jayakar |
| collection | DOAJ |
| description | The resounding success of imatinib (IM) as front line treatment in patients with chronic myeloid leukemia (CML) has certainly made a paradigm shift in the therapeutic algorithm of this disorder. The precise targeting of the BCR-ABL oncogene in CML has entitled it to be the poster child of translational medicine with a well-deserved Oscar ovation from the oncology community. Clinicians are now empowered with first-, second- and third-generation tyrosine kinases, as well as advanced molecular tools to monitor disease and characterize resistance. We have come a long way in successfully managing these patients, but there are still a significant few unmet clinical needs which need addressing and targeting to optimize clinical outcomes. This review focuses on 4 such pertinent and relevant clinical issues, which still need ironing out to fulfill our ambition of achieving ‘perfection’ in this patient cohort. |
| first_indexed | 2024-12-16T10:05:05Z |
| format | Article |
| id | doaj.art-f6588b2a4a3a4b67af5acac8db1fc4e0 |
| institution | Directory Open Access Journal |
| issn | 2278-330X 2278-4306 |
| language | English |
| last_indexed | 2024-12-16T10:05:05Z |
| publishDate | 2012-07-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | South Asian Journal of Cancer |
| spelling | doaj.art-f6588b2a4a3a4b67af5acac8db1fc4e02022-12-21T22:35:41ZengThieme Medical and Scientific Publishers Pvt. Ltd.South Asian Journal of Cancer2278-330X2278-43062012-07-010101162410.4103/2278-330X.96498Chronic myeloid leukemia: In pursuit of perfectionVishal Jayakar0Consultant Haemato-Oncologist, Kingston and Royal Marsden Hospitals, London, UKThe resounding success of imatinib (IM) as front line treatment in patients with chronic myeloid leukemia (CML) has certainly made a paradigm shift in the therapeutic algorithm of this disorder. The precise targeting of the BCR-ABL oncogene in CML has entitled it to be the poster child of translational medicine with a well-deserved Oscar ovation from the oncology community. Clinicians are now empowered with first-, second- and third-generation tyrosine kinases, as well as advanced molecular tools to monitor disease and characterize resistance. We have come a long way in successfully managing these patients, but there are still a significant few unmet clinical needs which need addressing and targeting to optimize clinical outcomes. This review focuses on 4 such pertinent and relevant clinical issues, which still need ironing out to fulfill our ambition of achieving ‘perfection’ in this patient cohort.http://www.thieme-connect.de/DOI/DOI?10.4103/2278-330X.96498chronic phase chronic myeloid leukemiacuretyrosine kinase inhibitor |
| spellingShingle | Vishal Jayakar Chronic myeloid leukemia: In pursuit of perfection South Asian Journal of Cancer chronic phase chronic myeloid leukemia cure tyrosine kinase inhibitor |
| title | Chronic myeloid leukemia: In pursuit of perfection |
| title_full | Chronic myeloid leukemia: In pursuit of perfection |
| title_fullStr | Chronic myeloid leukemia: In pursuit of perfection |
| title_full_unstemmed | Chronic myeloid leukemia: In pursuit of perfection |
| title_short | Chronic myeloid leukemia: In pursuit of perfection |
| title_sort | chronic myeloid leukemia in pursuit of perfection |
| topic | chronic phase chronic myeloid leukemia cure tyrosine kinase inhibitor |
| url | http://www.thieme-connect.de/DOI/DOI?10.4103/2278-330X.96498 |
| work_keys_str_mv | AT vishaljayakar chronicmyeloidleukemiainpursuitofperfection |