Calpains as Potential Therapeutic Targets for Myocardial Hypertrophy
Despite advances in its treatment, heart failure remains a major cause of morbidity and mortality, evidencing an urgent need for novel mechanism-based targets and strategies. Myocardial hypertrophy, caused by a wide variety of chronic stress stimuli, represents an independent risk factor for the dev...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/23/8/4103 |
| _version_ | 1797434597692145664 |
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| author | David Aluja Sara Delgado-Tomás Marisol Ruiz-Meana José A. Barrabés Javier Inserte |
| author_facet | David Aluja Sara Delgado-Tomás Marisol Ruiz-Meana José A. Barrabés Javier Inserte |
| author_sort | David Aluja |
| collection | DOAJ |
| description | Despite advances in its treatment, heart failure remains a major cause of morbidity and mortality, evidencing an urgent need for novel mechanism-based targets and strategies. Myocardial hypertrophy, caused by a wide variety of chronic stress stimuli, represents an independent risk factor for the development of heart failure, and its prevention constitutes a clinical objective. Recent studies performed in preclinical animal models support the contribution of the Ca<sup>2+</sup>-dependent cysteine proteases calpains in regulating the hypertrophic process and highlight the feasibility of their long-term inhibition as a pharmacological strategy. In this review, we discuss the existing evidence implicating calpains in the development of cardiac hypertrophy, as well as the latest advances in unraveling the underlying mechanisms. Finally, we provide an updated overview of calpain inhibitors that have been explored in preclinical models of cardiac hypertrophy and the progress made in developing new compounds that may serve for testing the efficacy of calpain inhibition in the treatment of pathological cardiac hypertrophy. |
| first_indexed | 2024-03-09T10:34:40Z |
| format | Article |
| id | doaj.art-f6591c1945954f398f7ebcb573e7c6f4 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T10:34:40Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-f6591c1945954f398f7ebcb573e7c6f42023-12-01T21:01:59ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-04-01238410310.3390/ijms23084103Calpains as Potential Therapeutic Targets for Myocardial HypertrophyDavid Aluja0Sara Delgado-Tomás1Marisol Ruiz-Meana2José A. Barrabés3Javier Inserte4Cardiovascular Diseases Research Group, Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron Hospital Universitari, Passeig Vall d’Hebron 119-129, 08035 Barcelona, SpainCardiovascular Diseases Research Group, Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron Hospital Universitari, Passeig Vall d’Hebron 119-129, 08035 Barcelona, SpainCardiovascular Diseases Research Group, Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron Hospital Universitari, Passeig Vall d’Hebron 119-129, 08035 Barcelona, SpainCardiovascular Diseases Research Group, Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron Hospital Universitari, Passeig Vall d’Hebron 119-129, 08035 Barcelona, SpainCardiovascular Diseases Research Group, Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron Hospital Universitari, Passeig Vall d’Hebron 119-129, 08035 Barcelona, SpainDespite advances in its treatment, heart failure remains a major cause of morbidity and mortality, evidencing an urgent need for novel mechanism-based targets and strategies. Myocardial hypertrophy, caused by a wide variety of chronic stress stimuli, represents an independent risk factor for the development of heart failure, and its prevention constitutes a clinical objective. Recent studies performed in preclinical animal models support the contribution of the Ca<sup>2+</sup>-dependent cysteine proteases calpains in regulating the hypertrophic process and highlight the feasibility of their long-term inhibition as a pharmacological strategy. In this review, we discuss the existing evidence implicating calpains in the development of cardiac hypertrophy, as well as the latest advances in unraveling the underlying mechanisms. Finally, we provide an updated overview of calpain inhibitors that have been explored in preclinical models of cardiac hypertrophy and the progress made in developing new compounds that may serve for testing the efficacy of calpain inhibition in the treatment of pathological cardiac hypertrophy.https://www.mdpi.com/1422-0067/23/8/4103calpaincalpastatinmyocardial hypertrophyheart failure |
| spellingShingle | David Aluja Sara Delgado-Tomás Marisol Ruiz-Meana José A. Barrabés Javier Inserte Calpains as Potential Therapeutic Targets for Myocardial Hypertrophy International Journal of Molecular Sciences calpain calpastatin myocardial hypertrophy heart failure |
| title | Calpains as Potential Therapeutic Targets for Myocardial Hypertrophy |
| title_full | Calpains as Potential Therapeutic Targets for Myocardial Hypertrophy |
| title_fullStr | Calpains as Potential Therapeutic Targets for Myocardial Hypertrophy |
| title_full_unstemmed | Calpains as Potential Therapeutic Targets for Myocardial Hypertrophy |
| title_short | Calpains as Potential Therapeutic Targets for Myocardial Hypertrophy |
| title_sort | calpains as potential therapeutic targets for myocardial hypertrophy |
| topic | calpain calpastatin myocardial hypertrophy heart failure |
| url | https://www.mdpi.com/1422-0067/23/8/4103 |
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