Study of sedative and anxiolytic effects of polar, semi-polar and non-polar fractions of Artemisia Aucheri extract compared with diazepam in rats
Abstract Artemisia Aucheri is a medicinal plant which has powerful sedative and anxiolytic effects. Also there are a lot of anti-oxidant agents in its extract. The purpose of this research is studying the sedative and anxiolytic effects of polar, semi-polar and non-polar fractions, extracted from...
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| Format: | Article |
| Language: | fas |
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Islamic Azad University, Tabriz Branch
2013-05-01
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| Series: | Āsīb/shināsī-i Darmāngāhī-i Dāmpizishkī |
| Subjects: | |
| Online Access: | http://jvcp.iaut.ac.ir/article_520526_1692b5aeb24d982eb7aec663a74f45ea.pdf |
| _version_ | 1818096094937088000 |
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| author | ramin shishiehgar bahloul habibiasl changiz ahmadizadeh |
| author_facet | ramin shishiehgar bahloul habibiasl changiz ahmadizadeh |
| author_sort | ramin shishiehgar |
| collection | DOAJ |
| description | Abstract
Artemisia Aucheri is a medicinal plant which has powerful sedative and anxiolytic effects. Also there are a lot of anti-oxidant agents in its extract. The purpose of this research is studying the sedative and anxiolytic effects of polar, semi-polar and non-polar fractions, extracted from Artemisia Aucheri in comparison with diazepam in the animal model of Rat. For this purpose, polar, semi-polar and non-polar fractions were extracted from Artemisia Aucheri, based on the polarity of solvent. The injection of the obtained fractions and other medications were made to different groups of female wistar rats which the same age and weight. Group was injected with 100mg/kg of Polar fraction extract, the second group with 100mg/kg of Semi-polar extract, the third group, with 100 mg/kg of non-polar extract of Artemisia Aucheri, the fourth group with 2 mg/kg of Diazepam, the fifth group with the same volume of Dimethyl Sulfoxide (DMSO) for studying the effect of solvent. The method of injection was Intra peritoneal (IP) form. The sixth group was the control group and did not receive any medications. Thirty minutes after injections, Ketamin 100 mg/kg was injected intraperitoneally in all 6 groups. Then induction and sleeping time was measured in seconds. Statistical results showed a meaningful decrease of anesthetic induction time and increase of sleeping time of Ketamin-induced anesthesia, after IP injection of the Polar fraction of Artemisia Aucheri (P |
| first_indexed | 2024-12-10T22:59:10Z |
| format | Article |
| id | doaj.art-f65921e44fe74854a29c5ec08d44ad82 |
| institution | Directory Open Access Journal |
| issn | 2322-4746 2476-6984 |
| language | fas |
| last_indexed | 2024-12-10T22:59:10Z |
| publishDate | 2013-05-01 |
| publisher | Islamic Azad University, Tabriz Branch |
| record_format | Article |
| series | Āsīb/shināsī-i Darmāngāhī-i Dāmpizishkī |
| spelling | doaj.art-f65921e44fe74854a29c5ec08d44ad822022-12-22T01:30:12ZfasIslamic Azad University, Tabriz BranchĀsīb/shināsī-i Darmāngāhī-i Dāmpizishkī2322-47462476-69842013-05-0171 (25) بهار17441752520526Study of sedative and anxiolytic effects of polar, semi-polar and non-polar fractions of Artemisia Aucheri extract compared with diazepam in ratsramin shishiehgar0bahloul habibiasl1changiz ahmadizadeh2دانشگاه آزاد اسلامی، واحد اهر، مربی گروه علوم پایه، اهر، ایران.گروه فارماکولوژی، دانشیار دانشگاه تبریز، دانشکده داروسازی، تبریز، ایران.دانشگاه آزاد اسلامی، واحد اهر، مربی گروه میکروبیولوژی، اهر، ایران.Abstract Artemisia Aucheri is a medicinal plant which has powerful sedative and anxiolytic effects. Also there are a lot of anti-oxidant agents in its extract. The purpose of this research is studying the sedative and anxiolytic effects of polar, semi-polar and non-polar fractions, extracted from Artemisia Aucheri in comparison with diazepam in the animal model of Rat. For this purpose, polar, semi-polar and non-polar fractions were extracted from Artemisia Aucheri, based on the polarity of solvent. The injection of the obtained fractions and other medications were made to different groups of female wistar rats which the same age and weight. Group was injected with 100mg/kg of Polar fraction extract, the second group with 100mg/kg of Semi-polar extract, the third group, with 100 mg/kg of non-polar extract of Artemisia Aucheri, the fourth group with 2 mg/kg of Diazepam, the fifth group with the same volume of Dimethyl Sulfoxide (DMSO) for studying the effect of solvent. The method of injection was Intra peritoneal (IP) form. The sixth group was the control group and did not receive any medications. Thirty minutes after injections, Ketamin 100 mg/kg was injected intraperitoneally in all 6 groups. Then induction and sleeping time was measured in seconds. Statistical results showed a meaningful decrease of anesthetic induction time and increase of sleeping time of Ketamin-induced anesthesia, after IP injection of the Polar fraction of Artemisia Aucheri (Phttp://jvcp.iaut.ac.ir/article_520526_1692b5aeb24d982eb7aec663a74f45ea.pdfArtemisia AucherifractionsDimethyl sulfoxideDiazepamRat |
| spellingShingle | ramin shishiehgar bahloul habibiasl changiz ahmadizadeh Study of sedative and anxiolytic effects of polar, semi-polar and non-polar fractions of Artemisia Aucheri extract compared with diazepam in rats Āsīb/shināsī-i Darmāngāhī-i Dāmpizishkī Artemisia Aucheri fractions Dimethyl sulfoxide Diazepam Rat |
| title | Study of sedative and anxiolytic effects of polar, semi-polar and non-polar fractions of Artemisia Aucheri extract compared with diazepam in rats |
| title_full | Study of sedative and anxiolytic effects of polar, semi-polar and non-polar fractions of Artemisia Aucheri extract compared with diazepam in rats |
| title_fullStr | Study of sedative and anxiolytic effects of polar, semi-polar and non-polar fractions of Artemisia Aucheri extract compared with diazepam in rats |
| title_full_unstemmed | Study of sedative and anxiolytic effects of polar, semi-polar and non-polar fractions of Artemisia Aucheri extract compared with diazepam in rats |
| title_short | Study of sedative and anxiolytic effects of polar, semi-polar and non-polar fractions of Artemisia Aucheri extract compared with diazepam in rats |
| title_sort | study of sedative and anxiolytic effects of polar semi polar and non polar fractions of artemisia aucheri extract compared with diazepam in rats |
| topic | Artemisia Aucheri fractions Dimethyl sulfoxide Diazepam Rat |
| url | http://jvcp.iaut.ac.ir/article_520526_1692b5aeb24d982eb7aec663a74f45ea.pdf |
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