Signatures of balancing selection are maintained at disease resistance loci following mating system evolution and a population bottleneck in the genus Capsella
<p>Abstract</p> <p>Background</p> <p>Population bottlenecks can lead to a loss of variation at disease resistance loci, which could have important consequences for the ability of populations to adapt to pathogen pressure. Alternatively, current or past balancing selecti...
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| Format: | Article |
| Language: | English |
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BMC
2012-08-01
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| Series: | BMC Evolutionary Biology |
| Subjects: | |
| Online Access: | http://www.biomedcentral.com/1471-2148/12/152 |
| _version_ | 1818570130105303040 |
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| author | Gos Gesseca Slotte Tanja Wright Stephen I |
| author_facet | Gos Gesseca Slotte Tanja Wright Stephen I |
| author_sort | Gos Gesseca |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Population bottlenecks can lead to a loss of variation at disease resistance loci, which could have important consequences for the ability of populations to adapt to pathogen pressure. Alternatively, current or past balancing selection could maintain high diversity, creating a strong heterogeneity in the retention of polymorphism across the genome of bottlenecked populations. We sequenced part of the LRR region of 9 NBS-LRR disease resistance genes in the outcrossing <it>Capsella grandiflora</it> and the recently derived, bottlenecked selfing species <it>Capsella rubella</it>, and compared levels and patterns of nucleotide diversity and divergence with genome-wide reference loci.</p> <p>Results</p> <p>In strong contrast with reference loci, average diversity at resistance loci was comparable between <it>C. rubella</it> and <it>C. grandiflora</it>, primarily due to two loci with highly elevated diversity indicative of past or present balancing selection. Average between-species differentiation was also reduced at the set of R-genes compared with reference loci, which is consistent with the maintenance of ancestral polymorphism.</p> <p>Conclusions</p> <p>Historical or ongoing balancing selection on plant disease resistance genes is a likely contributor to the retention of ancestral polymorphism in some regions of the bottlenecked <it>Capella rubella</it> genome.</p> |
| first_indexed | 2024-12-14T06:56:37Z |
| format | Article |
| id | doaj.art-f6594c661b8247528198752e9575149a |
| institution | Directory Open Access Journal |
| issn | 1471-2148 |
| language | English |
| last_indexed | 2024-12-14T06:56:37Z |
| publishDate | 2012-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Evolutionary Biology |
| spelling | doaj.art-f6594c661b8247528198752e9575149a2022-12-21T23:12:38ZengBMCBMC Evolutionary Biology1471-21482012-08-0112115210.1186/1471-2148-12-152Signatures of balancing selection are maintained at disease resistance loci following mating system evolution and a population bottleneck in the genus CapsellaGos GessecaSlotte TanjaWright Stephen I<p>Abstract</p> <p>Background</p> <p>Population bottlenecks can lead to a loss of variation at disease resistance loci, which could have important consequences for the ability of populations to adapt to pathogen pressure. Alternatively, current or past balancing selection could maintain high diversity, creating a strong heterogeneity in the retention of polymorphism across the genome of bottlenecked populations. We sequenced part of the LRR region of 9 NBS-LRR disease resistance genes in the outcrossing <it>Capsella grandiflora</it> and the recently derived, bottlenecked selfing species <it>Capsella rubella</it>, and compared levels and patterns of nucleotide diversity and divergence with genome-wide reference loci.</p> <p>Results</p> <p>In strong contrast with reference loci, average diversity at resistance loci was comparable between <it>C. rubella</it> and <it>C. grandiflora</it>, primarily due to two loci with highly elevated diversity indicative of past or present balancing selection. Average between-species differentiation was also reduced at the set of R-genes compared with reference loci, which is consistent with the maintenance of ancestral polymorphism.</p> <p>Conclusions</p> <p>Historical or ongoing balancing selection on plant disease resistance genes is a likely contributor to the retention of ancestral polymorphism in some regions of the bottlenecked <it>Capella rubella</it> genome.</p>http://www.biomedcentral.com/1471-2148/12/152Capsella <it>grandiflora</it>Capsella rubellaR-genesBalancing selectionRelaxed constraintPopulation bottleneck |
| spellingShingle | Gos Gesseca Slotte Tanja Wright Stephen I Signatures of balancing selection are maintained at disease resistance loci following mating system evolution and a population bottleneck in the genus Capsella BMC Evolutionary Biology Capsella <it>grandiflora</it> Capsella rubella R-genes Balancing selection Relaxed constraint Population bottleneck |
| title | Signatures of balancing selection are maintained at disease resistance loci following mating system evolution and a population bottleneck in the genus Capsella |
| title_full | Signatures of balancing selection are maintained at disease resistance loci following mating system evolution and a population bottleneck in the genus Capsella |
| title_fullStr | Signatures of balancing selection are maintained at disease resistance loci following mating system evolution and a population bottleneck in the genus Capsella |
| title_full_unstemmed | Signatures of balancing selection are maintained at disease resistance loci following mating system evolution and a population bottleneck in the genus Capsella |
| title_short | Signatures of balancing selection are maintained at disease resistance loci following mating system evolution and a population bottleneck in the genus Capsella |
| title_sort | signatures of balancing selection are maintained at disease resistance loci following mating system evolution and a population bottleneck in the genus capsella |
| topic | Capsella <it>grandiflora</it> Capsella rubella R-genes Balancing selection Relaxed constraint Population bottleneck |
| url | http://www.biomedcentral.com/1471-2148/12/152 |
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