Catch bond models may explain how force amplifies TCR signaling and antigen discrimination
Abstract The TCR integrates forces in its triggering process upon interaction with pMHC. Force elicits TCR catch-slip bonds with strong pMHCs but slip-only bonds with weak pMHCs. We develop two models and apply them to analyze 55 datasets, demonstrating the models’ ability to quantitatively integrat...
| Autori principali: | , , , , , , , , , , , |
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| Natura: | Articolo |
| Lingua: | English |
| Pubblicazione: |
Nature Portfolio
2023-05-01
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| Serie: | Nature Communications |
| Accesso online: | https://doi.org/10.1038/s41467-023-38267-1 |