Stress Affects Central Compensation of Neural Responses to Cochlear Synaptopathy in a cGMP-Dependent Way

Stress Affects Central Compensation of Neural Responses to Cochlear Synaptopathy in a cGMP-Dependent Way

In light of the increasing evidence supporting a link between hearing loss and dementia, it is critical to gain a better understanding of the nature of this relationship. We have previously observed that following cochlear synaptopathy, the temporal auditory processing (e.g., auditory steady state r...

Full description

Bibliographic Details
Main Authors:	Daria Savitska, Morgan Hess, Dila Calis, Philine Marchetta, Csaba Harasztosi, Stefan Fink, Philipp Eckert, Peter Ruth, Lukas Rüttiger, Marlies Knipper, Wibke Singer
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-07-01
Series:	Frontiers in Neuroscience
Subjects:	long-term potentiation cochlear synaptopathy phosphodiesterase 9A inhibitor (PDE9i) cGMP glucocorticoid blunted stress response
Online Access:	https://www.frontiersin.org/articles/10.3389/fnins.2022.864706/full

Similar Items

Phosphodiesterase 9A in Brain Regulates cGMP Signaling Independent of Nitric-Oxide
by: John F. Harms, et al.
Published: (2019-08-01)

Role of Phosphodiesterase 1 in the Regulation of Real-Time cGMP Levels and Contractility in Adult Mouse Cardiomyocytes
by: Nadja I. Bork, et al.
Published: (2023-12-01)

Pros and Cons of Pharmacological Manipulation of cGMP-PDEs in the Prevention and Treatment of Breast Cancer
by: Patrizia Di Iorio, et al.
Published: (2021-12-01)

cGMP Signaling in Photoreceptor Degeneration
by: Shujuan Li, et al.
Published: (2023-07-01)

Compartmentation of cGMP Signaling in Induced Pluripotent Stem Cell Derived Cardiomyocytes during Prolonged Culture
by: Maria Faleeva, et al.
Published: (2022-10-01)

Rise of cGMP by partial phosphodiesterase-3A degradation enhances cardioprotection during hypoxia
by: Nadja I. Bork, et al.
Published: (2021-12-01)

Imaging of PDE2- and PDE3-Mediated cGMP-to-cAMP Cross-Talk in Cardiomyocytes
by: Nikoleta Pavlaki, et al.
Published: (2018-01-01)

Guanylyl Cyclase A/cGMP Signaling Slows Hidden, Age- and Acoustic Trauma-Induced Hearing Loss
by: Philine Marchetta, et al.
Published: (2020-04-01)

Characterization and Modification of Light-Sensitive Phosphodiesterases from Choanoflagellates
by: Yuehui Tian, et al.
Published: (2022-01-01)

Sub-nanomolar sensitivity of nitric oxide mediated regulation of cGMP and vasomotor reactivity in vascular smooth muscle
by: Kara F. Held, et al.
Published: (2012-07-01)

Memory Enhancers for Alzheimer’s Dementia: Focus on cGMP
by: Ernesto Fedele, et al.
Published: (2021-01-01)

Plasticity and therapeutic potential of cAMP and cGMP-specific phosphodiesterases in Toxoplasma gondii
by: Kim Chi Vo, et al.
Published: (2022-01-01)

Multi-Compartment, Early Disruption of cGMP and cAMP Signalling in Cardiac Myocytes from the <i>mdx</i> Model of Duchenne Muscular Dystrophy
by: Marcella Brescia, et al.
Published: (2020-09-01)

Apicomplexan phosphodiesterases in cyclic nucleotide turnover: conservation, function, and therapeutic potential
by: William J. Moss, et al.
Published: (2024-02-01)

cGMP-Dependent Protein Kinase Inhibitors in Health and Disease
by: Jens Schlossmann, et al.
Published: (2013-02-01)

Upregulation of Phosphodiesterase 2A Augments T Cell Activation by Changing cGMP/cAMP Cross-Talk
by: Roberta Kurelic, et al.
Published: (2021-10-01)

Novel Barbiturate-Nitrate Compounds Inhibit the Upregulation of Matrix Metalloproteinase-9 Gene Expression in Intestinal Inflammation through a cGMP-Mediated Pathway
by: Shane O’Sullivan, et al.
Published: (2020-05-01)

Functional Axis of PDE5/cGMP Mediates Timosaponin-AIII-Elicited Growth Suppression of Glioblastoma U87MG Cells
by: Ya-Fang Liao, et al.
Published: (2023-04-01)

Myostatin Mutation Promotes Glycolysis by Increasing Phosphorylation of Phosphofructokinase via Activation of PDE5A-cGMP-PKG in Cattle Heart
by: Mingjuan Gu, et al.
Published: (2022-01-01)

Therapeutic Implications for PDE2 and cGMP/cAMP Mediated Crosstalk in Cardiovascular Diseases
by: Mirna S. Sadek, et al.
Published: (2020-10-01)

A Perspective on Natural and Nature-Inspired Small Molecules Targeting Phosphodiesterase 9 (PDE9): Chances and Challenges against Neurodegeneration
by: Giovanni Ribaudo, et al.
Published: (2021-01-01)

Age-Dependent Auditory Processing Deficits after Cochlear Synaptopathy Depend on Auditory Nerve Latency and the Ability of the Brain to Recruit LTP/BDNF
by: Philine Marchetta, et al.
Published: (2020-10-01)

Optogenetic manipulation of cyclic guanosine monophosphate to probe phosphodiesterase activities in megakaryocytes
by: Yujing Zhang, et al.
Published: (2022-08-01)

A Real-Time, Plate-Based BRET Assay for Detection of cGMP in Primary Cells
by: Adam L. Valkovic, et al.
Published: (2022-02-01)

The Role of NO/sGC/cGMP/PKG Signaling Pathway in Regulation of Platelet Function
by: Stepan Gambaryan
Published: (2022-11-01)

Saxagliptin and Tadalafil Differentially Alter Cyclic Guanosine Monophosphate (cGMP) Signaling and Left Ventricular Function in Aortic‐Banded Mini‐Swine
by: Jessica A. Hiemstra, et al.
Published: (2016-04-01)

β3-Adrenoceptor redistribution impairs NO/cGMP/PDE2 signalling in failing cardiomyocytes
by: Sophie Schobesberger, et al.
Published: (2020-03-01)

Functions of PDE3 Isoforms in Cardiac Muscle
by: Matthew Movsesian, et al.
Published: (2018-02-01)

The Complexity and Multiplicity of the Specific cAMP Phosphodiesterase Family: PDE4, Open New Adapted Therapeutic Approaches
by: Claire Lugnier
Published: (2022-09-01)

Hyperammonemia impairs long-term potentiation in hippocampus by altering the modulation of cGMP-degrading phosphodiesterase by protein kinase G
by: Pilar Monfort, et al.
Published: (2004-02-01)

Plasmodium falciparum cGMP-Dependent Protein Kinase – A Novel Chemotherapeutic Target
by: David Rotella, et al.
Published: (2021-02-01)

Corrigendum: Systemic induction of NO-, redox- and cGMP signaling in the pumpkin extrafascicular phloem upon local leaf wounding
by: Frank eGaupels
Published: (2016-03-01)

Moonlighting Proteins and Their Role in the Control of Signaling Microenvironments, as Exemplified by cGMP and Phytosulfokine Receptor 1 (PSKR1)
by: Helen R. Irving, et al.
Published: (2018-03-01)

Programmed Non-Apoptotic Cell Death in Hereditary Retinal Degeneration: Crosstalk between cGMP-Dependent Pathways and PARthanatos?
by: Jie Yan, et al.
Published: (2021-09-01)

Effect of aerobic exercise training on cGMP levels and blood pressure in treated hypertensive postmenopausal women
by: Iane P Novais, et al.

Phosphodiesterases in the Liver as Potential Therapeutic Targets of Cirrhotic Portal Hypertension
by: Wolfgang Kreisel, et al.
Published: (2020-08-01)

Regulation of the renin-angiotensin-aldosterone system by cyclic nucleotides and phosphodiesterases
by: Stepan Gambaryan, et al.
Published: (2023-08-01)

S-palmitoylation Is Required for the Control of Growth Cone Morphology of DRG Neurons by CNP-Induced cGMP Signaling
by: Alexandre Dumoulin, et al.
Published: (2018-09-01)

Investigation of Potential cGMP-Specific PDE V and Aminopeptidase N Inhibitors of <i>Allium ampeloprasum</i> L. and Its Bioactive Components: Kinetic and Molecular Docking Studies
by: Jun-Hui Choi, et al.
Published: (2023-08-01)

Intermingled cAMP, cGMP and calcium spatiotemporal dynamics in developing neuronal circuits
by: Stefania eAveraimo, et al.
Published: (2014-11-01)