Therapeutic drug monitoring of mexiletine at a large academic medical center

Therapeutic drug monitoring of mexiletine at a large academic medical center

Introduction: The therapeutic trough range for mexiletine (0.8–2 mcg/mL) was largely established in the setting of arrhythmia prophylaxis following myocardial infarction. Objective: Describe the usage patterns of serum mexiletine concentrations and the impact of these concentrations on mexiletine do...

Full description

Bibliographic Details
Main Authors:	Scott D Nei, Ilya M Danelich, Jennifer M Lose, Lydia Yuk Ting Leung, Samuel J Asirvatham, Christopher J McLeod
Format:	Article
Language:	English
Published:	SAGE Publishing 2016-09-01
Series:	SAGE Open Medicine
Online Access:	https://doi.org/10.1177/2050312116670659

Similar Items

A patient with mexiletine-related psychosis
by: Shailesh F, et al.
Published: (2011-11-01)

Molecular Modeling of Cardiac Sodium Channel with Mexiletine
by: Boris S. Zhorov
Published: (2022-12-01)

Mexiletine Reverses Oxaliplatin-Induced Neuropathic Pain in Rats
by: Nobuaki Egashira, et al.
Published: (2010-01-01)

Effect of Mexiletine on Fenvalerate-Induced Nociceptive Response in Diabetic Mice
by: Junzo Kamei, et al.
Published: (2004-01-01)

Evaluation of mexiletine effect on duration of sensory and motor block in spinal anesthesia with lidocaine
by: M Haghbin, et al.
Published: (2014-05-01)

Mexiletine in spinal and bulbar muscular atrophy: a randomized controlled trial
by: Shinichiro Yamada, et al.
Published: (2022-11-01)

Case report: Mexiletine suppresses ventricular arrhythmias in Andersen-Tawil syndrome
by: Jing Yang, et al.
Published: (2022-08-01)

Clinical results of combined amiodarone and mexiletine therapy in refractory ventricular tachycardias
by: Shabnam Madadi, et al.
Published: (2019-01-01)

Mexiletine Differentially Restores the Trafficking Defects Caused by Two Brugada Syndrome Mutations
by: Adrien eMoreau, et al.
Published: (2012-04-01)

Mexiletine-like cellular electrophysiological effects of GS967 in canine ventricular myocardium
by: Tamás Hézső, et al.
Published: (2021-05-01)

Mexiletine Treatment for Neonatal LQT3 Syndrome: Case Report and Literature Review
by: Alena Bagkaki, et al.
Published: (2021-08-01)

Development and application of a validated HPLC method for the analysis of dissolution samples of mexiletine hydrochloride capsules
by: ZORAN B.TODOROVIĆ, et al.
Published: (2010-07-01)

Dual Action of Mexiletine and Its Pyrroline Derivatives as Skeletal Muscle Sodium Channel Blockers and Anti-oxidant Compounds: Toward Novel Therapeutic Potential
by: Michela De Bellis, et al.
Published: (2018-01-01)

Mexiletine shortens the QT interval in a pedigree of KCNH2 related long QT syndrome
by: Taishi Fujisawa, et al.
Published: (2020-02-01)

Mexiletine infusion challenge test for neonatal long QT syndrome with 2:1 atrioventricular block
by: Hajime Okuwaki, et al.
Published: (2019-08-01)

A comparative study on the effect of dopamine vs phenylephrine in improving the cutaneous analgesic effect of mexiletine in rats
by: Kesong Zheng, et al.
Published: (2023-06-01)

Evaluation of Mexiletine Effect on Bispectral Index Changes and Hemodynamic Responses to Endotracheal Intubation and During General Anesthesia
by: mohammad ali haghbin, et al.
Published: (2014-09-01)

Evaluation of Mexiletine Effect on Bispectral Index Changes and Hemodynamic Responses to Endotracheal Intubation and During General Anesthesia
by: mohammad ali haghbin, et al.
Published: (2014-09-01)

The Effect of Sodium Channel Blocker, Mexiletine, on Body Weight in Type 2 Diabetes Patients with Visceral Obesity
by: Naohiko Ueno
Published: (2019-01-01)

Effects of Mexiletine on a Race-specific Mutation in Nav1.5 Associated With Long QT Syndrome
by: Xin Wu, et al.
Published: (2022-07-01)

Long-Term Safety and Usefulness of Mexiletine in a Large Cohort of Patients Affected by Non-dystrophic Myotonias
by: Anna Modoni, et al.
Published: (2020-05-01)

Dual chamber pacing mode in an atrial antitachycardia pacing device without a ventricular lead – A necessary evil
by: Amit Noheria, et al.
Published: (2015-03-01)

Correction: A comparative study on the effect of dopamine vs phenylephrine in improving the cutaneous analgesic effect of mexiletine in rats
by: Kesong Zheng, et al.
Published: (2024-01-01)

Chiral Discrimination of Mexiletine Enantiomers by Capillary Electrophoresis Using Cyclodextrins as Chiral Selectors and Experimental Design Method Optimization
by: Melania Cârcu-Dobrin, et al.
Published: (2022-08-01)

Anti-Bronchospasmodic Effect of JME-173, a Novel Mexiletine Analog Endowed With Highly Attenuated Anesthetic Activity
by: Katharinne Ingrid Moraes Carvalho, et al.
Published: (2020-07-01)

Molecular insights into the local anesthetic receptor within voltage-gated sodium channels using hydroxylated analogues of mexiletine
by: Jean-François eDesaphy, et al.
Published: (2012-02-01)

H-NMR determination of the enantiomeric excess of the antiarrhytmic drug Mexiletine by using mandelic acid analogues as chiral solvating agents
by: Giuseppe Carbonara, et al.
Published: (2003-10-01)

Dramatic reduction of ventricular tachycardia burden after dronedarone plus mexiletine treatment in a patient refractory to hybrid ablation
by: Manuel Frutos-López, et al.
Published: (2020-03-01)

Mexiletine as a treatment for primary erythromelalgia: normalization of biophysical properties of mutant L858F NaV 1.7 sodium channels.
by: Cregg, R, et al.
Published: (2014)

Exploring the Textual and Tactile Weave of Academic Subjectivities:
by: Haley Toll, et al.
Published: (2023-08-01)

Muscle velocity recovery cycles as pharmacodynamic biomarker: Effects of mexiletine in a randomized double‐blind placebo‐controlled cross‐over study
by: Titia Q. Ruijs, et al.
Published: (2022-12-01)

Gating Properties of Mutant Sodium Channels and Responses to Sodium Current Inhibitors Predict Mexiletine-Sensitive Mutations of Long QT Syndrome 3
by: Gang Li, et al.
Published: (2020-08-01)

Comparison of Gating Properties and Use-Dependent Block of Nav1.5 and Nav1.7 Channels by Anti-Arrhythmics Mexiletine and Lidocaine.
by: Ying Wang, et al.
Published: (2015-01-01)

Resolution of Racemic Aryloxy-Propan-2-yl Acetates via Lipase-Catalyzed Hydrolysis: Preparation of Enantiomerically Pure/Enantioenriched Mexiletine Intermediates and Analogs
by: Ana Caroline Lustosa de Melo Carvalho, et al.
Published: (2022-12-01)

Verification of the Efficacy of Mexiletine Treatment for the A1656D Mutation on Downgrading Reentrant Tachycardia Using a 3D Cardiac Electrophysiological Model
by: Ali Ikhsanul Qauli, et al.
Published: (2022-10-01)

Curative Effect of Yangxin Dingji Capsule Combined With Mexiletine Hydrochloride on Postoperative Arrhythmia and Its Influences on the Vascular Endothelial Function in Coronary Bifurcation Lesions
by: Nasha Sun, et al.
Published: (2022-01-01)

Retracted: Curative Effect of Yangxin Dingji Capsule Combined With Mexiletine Hydrochloride on Postoperative Arrhythmia and Its Influences on the Vascular Endothelial Function in Coronary Bifurcation Lesions
by: Emergency Medicine International
Published: (2024-01-01)

Intramural conduction system gradients and electrogram regularity during ventricular fibrillation
by: Jason Tri, et al.
Published: (2018-11-01)

Implementing Personalized Medicine in the Academic Health Center
by: Scott T. Weiss
Published: (2016-09-01)

Sound transmission between 50 and 600 Hz in excised pig lungs filled with air and helium.
by: Leung, A, et al.
Published: (2000)