Telocytes in the urinary system

<p>Abstract</p> <p>Background</p> <p>Telocytes, a new type of interstitial cells, have been identified in many organs in mammals. The present studies aimed at investigating the ultrastructure, distribution and interactions of telocytes with surrounding cells in the urin...

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Main Authors: Zheng Yonghua, Zhu Tongyu, Lin Miao, Wu Duojiao, Wang Xiangdong
Format: Article
Language:English
Published: BMC 2012-09-01
Series:Journal of Translational Medicine
Subjects:
Online Access:http://www.translational-medicine.com/content/10/1/188
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author Zheng Yonghua
Zhu Tongyu
Lin Miao
Wu Duojiao
Wang Xiangdong
author_facet Zheng Yonghua
Zhu Tongyu
Lin Miao
Wu Duojiao
Wang Xiangdong
author_sort Zheng Yonghua
collection DOAJ
description <p>Abstract</p> <p>Background</p> <p>Telocytes, a new type of interstitial cells, have been identified in many organs in mammals. The present studies aimed at investigating the ultrastructure, distribution and interactions of telocytes with surrounding cells in the urinary system of rats, to confirm the existence of telocytes in kidneys, ureter and urinary bladder.</p> <p>Methods</p> <p>Samples of kidney, ureter, or urinary bladder were harvested for the ultrastructure by the electron microscope. The primary culture of telocytes was performed to investigate the dynamic alterations.</p> <p>Results</p> <p>Telocytes mainly located in the sub-capsular space of kidney, or between smooth muscle bundles and in the lamina propria of ureter and urinary bladder. Telocytes established numerous contacts with macrophages in the sub-capsular space of kidney, or with smooth muscle cells, nerve endings as well as blood capillaries in the ureter and urinary bladder. The complete morphology of telocytes with telopodes was observed clearly through the primary cell culture from the kidney tissues of rats.</p> <p>Conclusions</p> <p>Our data evidenced the existence of telocytes in the urinary system, which may contribute to the tissue reparation and regeneration.</p>
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spelling doaj.art-f66158dbdf1044c5b2b055f42a30d3ce2022-12-21T23:26:57ZengBMCJournal of Translational Medicine1479-58762012-09-0110118810.1186/1479-5876-10-188Telocytes in the urinary systemZheng YonghuaZhu TongyuLin MiaoWu DuojiaoWang Xiangdong<p>Abstract</p> <p>Background</p> <p>Telocytes, a new type of interstitial cells, have been identified in many organs in mammals. The present studies aimed at investigating the ultrastructure, distribution and interactions of telocytes with surrounding cells in the urinary system of rats, to confirm the existence of telocytes in kidneys, ureter and urinary bladder.</p> <p>Methods</p> <p>Samples of kidney, ureter, or urinary bladder were harvested for the ultrastructure by the electron microscope. The primary culture of telocytes was performed to investigate the dynamic alterations.</p> <p>Results</p> <p>Telocytes mainly located in the sub-capsular space of kidney, or between smooth muscle bundles and in the lamina propria of ureter and urinary bladder. Telocytes established numerous contacts with macrophages in the sub-capsular space of kidney, or with smooth muscle cells, nerve endings as well as blood capillaries in the ureter and urinary bladder. The complete morphology of telocytes with telopodes was observed clearly through the primary cell culture from the kidney tissues of rats.</p> <p>Conclusions</p> <p>Our data evidenced the existence of telocytes in the urinary system, which may contribute to the tissue reparation and regeneration.</p>http://www.translational-medicine.com/content/10/1/188TelocytesKidneyUreterUrinary bladder
spellingShingle Zheng Yonghua
Zhu Tongyu
Lin Miao
Wu Duojiao
Wang Xiangdong
Telocytes in the urinary system
Journal of Translational Medicine
Telocytes
Kidney
Ureter
Urinary bladder
title Telocytes in the urinary system
title_full Telocytes in the urinary system
title_fullStr Telocytes in the urinary system
title_full_unstemmed Telocytes in the urinary system
title_short Telocytes in the urinary system
title_sort telocytes in the urinary system
topic Telocytes
Kidney
Ureter
Urinary bladder
url http://www.translational-medicine.com/content/10/1/188
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AT zhutongyu telocytesintheurinarysystem
AT linmiao telocytesintheurinarysystem
AT wuduojiao telocytesintheurinarysystem
AT wangxiangdong telocytesintheurinarysystem