De novo peptide grafting to a self-assembling nanocapsule yields a hepatocyte growth factor receptor agonist

De novo peptide grafting to a self-assembling nanocapsule yields a hepatocyte growth factor receptor agonist

Summary: Lasso-grafting (LG) technology is a method for generating de novo biologics (neobiologics) by genetically implanting macrocyclic peptide pharmacophores, which are selected in vitro against a protein of interest, into loops of arbitrary protein scaffolds. In this study, we have generated a n...

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Bibliographic Details
Main Authors: Yamato Komatsu, Naohiro Terasaka, Katsuya Sakai, Emiko Mihara, Risa Wakabayashi, Kunio Matsumoto, Donald Hilvert, Junichi Takagi, Hiroaki Suga
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:iScience
Subjects:
Peptides
Biotechnology
Synthetic biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221012712

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