Exploration of Novel Mono Hydroxamic Acid Derivatives as Inhibitors for Histone Deacetylase Like Protein (HDLP) by Molecular Dynamics Studies

Exploration of Novel Mono Hydroxamic Acid Derivatives as Inhibitors for Histone Deacetylase Like Protein (HDLP) by Molecular Dynamics Studies

The acetylation modification process of histone has an essential role in the epigenetic regulation of gene expression. This process is controlled by the balance between histone deacetylases (HDAC) and histone acetyltransferases (HAT). HDACs are thought to be vital for cell function. Particularly, hi...

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Bibliographic Details
Main Authors: Gunasingham Parthiban, Ramachandren Dushanan, Samantha Weerasinghe, Dhammike Dissanayake, Rajendram Senthilnithy
Format: Article
Language:English
Published: Department of Chemistry, Universitas Gadjah Mada 2022-11-01
Series:Indonesian Journal of Chemistry
Subjects:
epigenetic regulation
hdac
mm-pbsa
ramachandran plot
hydroxamic acid derivatives
Online Access:https://jurnal.ugm.ac.id/ijc/article/view/74167

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