Blocking Lipid Uptake Pathways Does not Prevent Toxicity in Adipose Triglyceride Lipase (ATGL) Deficiency

Blocking Lipid Uptake Pathways Does not Prevent Toxicity in Adipose Triglyceride Lipase (ATGL) Deficiency

Lipid accumulation in nonadipose tissues can cause lipotoxicity, leading to cell death and severe organ dysfunction. Adipose triglyceride lipase (ATGL) deficiency causes human neutral lipid storage disease and leads to cardiomyopathy; ATGL deficiency has no current treatment. One possible approach t...

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Bibliographic Details
Main Authors: Jide Oluwadare, Ainara G. Cabodevilla, Ni-Huiping Son, Yunying Hu, Adam E. Mullick, Michael Verano, Jose O. Alemán, Ravichandran Ramasamy, Ira J. Goldberg
Format: Article
Language:English
Published: Elsevier 2022-11-01
Series:Journal of Lipid Research
Subjects:
CD36
dietary fat
lipid accumulation
lipotoxicity
storage diseases
LpL
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227522001079

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